Draft genomes of from patients with cholera-like illness during the 2022-2023 cholera outbreak in Malawi.

is an increasingly recognized etiological agent of acute gastroenteritis. Here, we report five draft genomes of isolated from suspected cholera cases during the 2022-2023 cholera outbreak in Malawi.

Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing.

To assess the potential of human induced pluripotent stem cell-derived smooth muscle cells (hiPSC-SMC) to accelerate diabetic wound healing. hiPSC-SMC were embedded in 3D collagen scaffolds and cultured for 72 h; scaffolds were then applied to diabetic, nude mouse, splinted back wounds to assess healing. Cultured medium after scaffold incubation was collected and analyzed for expression of pro-angiogenic cytokines.

Resampling QTL effects in the QTL sign test leads to incongruous sensitivity to variance in effect size.

Allelic effects at quantitative trait loci (QTL) between lineages are potentially informative for indicating the action of natural selection. The QTL Sign Test uses the number of + and - alleles observed in a QTL study to infer a history of selection. This test has been constructed to condition on the phenotypic difference between the two lines in question.

Extracellular chloride regulation of Kv2.1, contributor to the major outward Kv current in mammalian outer hair cells.

Outer hair cells (OHC) function as both receptors and effectors in providing a boost to auditory reception. Amplification is driven by the motor protein prestin, which is under anionic control. Interestingly, we now find that the major, 4-AP-sensitive, outward K(+) current of the OHC (I(K)) is also sensitive to Cl(-), although, in contrast to prestin, extracellularly.