Peripheral Blood Involvement at Staging in Patients With Aggressive Peripheral T-Cell Lymphoma.

Introduction: Peripheral T-Cell Lymphomas (PTCL) are a rare subgroup of lymphomas with a poor outcome.Traditional prognostic measures rely heavily on disease stage, and with the advent of targeted treatment, further stratificationcriteria are needed to guide treatment. To date, the impact of blood involvement at diagnosis on outcomes has not been assessed.

Molecular recognition of leucine-aspartate repeat (LD) motifs by the focal adhesion targeting homology domain of cerebral cavernous malformation 3 (CCM3).

Cerebral cavernous malformation (CCM) is a disease that affects between 0.1 and 0.5% of the human population, with mutations in CCM3 accounting for ~ 15% of the autosomal dominant form of the disease.

Diabetes as a cause of clinically significant functional cobalamin deficiency.

Objective: Functional cobalamin (Cbl) deficiency (i.e., high methylmalonic acid [MMA] values despite normal serum Cbl levels) is common in the elderly and associated with neuropathy and anemia.

More intensive hemodialysis.

Clinical outcomes have not improved substantially for patients treated with conventional thrice weekly hemodialysis. More intensive hemodialysis regimens, including daily short dialysis, and nocturnal prolonged dialysis show promise to improve morbidity and mortality. Published studies and trials underway examining these therapies are reviewed.

Correspondence of motivational enhancement treatment integrity ratings among therapists, supervisors, and observers.

This study examined the correspondence of treatment integrity ratings (adherence and competence) among community program therapists, supervisors, and observers for therapists who used motivational enhancement therapy (MET) within a National Institute on Drug Abuse Clinical Trials Network protocol. The results suggested there was reasonable agreement between the three groups of raters about the presence or absence of several fundamental MET strategies. Moreover, relative to observers, therapists and supervisors were more positive in their evaluations of the therapists' MET adherence and competence.

Screening for preexisting cognitive impairment in older intensive care unit patients: use of proxy assessment.

Objectives: To determine the prevalence of preexisting cognitive impairment (CI) in patients admitted to the medical intensive care unit (ICU) and compare two different proxy measures of preexisting CI in ICU patients.

Design: Cross-sectional comparative study.

Setting: Urban university teaching hospital.