2 results match your criteria: "Yale University School of Medicine and The Howard Hughes Medical Institute[Affiliation]"
Interchromosomal association and gene regulation in trans.
Trends Genet
April 2010
Department of Immunobiology, Yale University School of Medicine and The Howard Hughes Medical Institute, New Haven, CT 06520, USA.
Article Synopsis
- The nucleus has a structured 3D organization that influences gene expression by positioning the genome effectively within its space.
- Recent technology has shown that chromatin forms loops to connect distant regulatory elements with the genes they control, a key mechanism for enhancer-promoter communication.
- There are emerging suggestions that regulatory elements might influence genes on different chromosomes, but definitive evidence is still needed, highlighting ongoing debates and gaps in our understanding of gene expression mechanisms.
Negative selection of thymocytes expressing the D10 TCR.
Proc Natl Acad Sci U S A
May 2002
Section of Immunobiology, Yale University School of Medicine and the Howard Hughes Medical Institute, New Haven, CT 06520, USA.
We have analyzed the patterns of positive and negative selection of thymocytes expressing the T cell antigen receptor (TCR) from the D10.G4.1 T cell clone.
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