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Proc Natl Acad Sci U S A
April 2016
Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College of Cornell University, New York, NY 10065; Department of Psychiatry, Weill Cornell Medical College of Cornell University, New York, NY 10065;
Anxiety disorders peak in incidence during adolescence, a developmental window that is marked by dynamic changes in gene expression, endocannabinoid signaling, and frontolimbic circuitry. We tested whether genetic alterations in endocannabinoid signaling related to a common polymorphism in fatty acid amide hydrolase (FAAH), which alters endocannabinoid anandamide (AEA) levels, would impact the development of frontolimbic circuitry implicated in anxiety disorders. In a pediatric imaging sample of over 1,000 3- to 21-y-olds, we show effects of the FAAH genotype specific to frontolimbic connectivity that emerge by ∼12 y of age and are paralleled by changes in anxiety-related behavior.
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