360 results match your criteria: "Yale School of Medicine New Haven[Affiliation]"

Article Synopsis
  • This study examined the impact of frailty on outcomes in older patients (≥65 years) undergoing dual antiplatelet therapy (DAPT) after percutaneous coronary intervention, using Medicare claims data to define frailty.
  • Results showed that frail patients had a significantly higher rate of adverse clinical events (23.1%) compared to nonfrail patients (10.7%) at 18 months follow-up.
  • While there were no notable differences in the effects of standard versus extended duration DAPT on outcomes for frail versus nonfrail patients, further research is needed to explore how frailty affects bleeding and ischemic risks with DAPT.
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  • Accountable care organizations (ACOs) aim to enhance healthcare quality and lower costs for heart failure patients, but there’s limited understanding of admission rate variations across different ACOs.
  • A study of over 1.2 million heart failure patients revealed significant differences in acute admission rates among 467 ACOs, with a median of 87 admissions per 100 people, highlighting that 13% performed better while 14% performed worse than average.
  • ACOs that had better performance generally had fewer Black beneficiaries and were independent, while those that fared worse tended to be large, hospital-affiliated, and located in the Northeast with fewer primary care providers.
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It is well recognized by the general public that breastfeeding expends calories. In our clinical practice, a number of postpartum women with a history of or a current eating disorder (ED) report using breastfeeding and/or pumping breast milk to influence their body shape and weight. This appears to be either a form of weight control behavior or, in some cases, a compensation for perceived overeating or binge eating.

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Background Fetal diagnosis of congenitally corrected transposition of the great arteries (ccTGA) has been increasingly reported; however, predictors of clinical outcomes remain underexplored. We undertook a multicenter, retrospective study to investigate natural history, associated anomalies, and outcomes of fetal ccTGA. Methods and Results Fetuses with ccTGA diagnosed from January 2004 to July 2020 within 20 North American programs were included.

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  • Current clinical recommendations for young athletes with cardiovascular conditions are mainly based on expert consensus, lacking robust data on outcomes.
  • The ORCCA study aims to monitor the health and decision-making of competitive athletes aged 18-35 with cardiovascular issues over a 5-year period, focusing on sports participation and psychosocial well-being.
  • This research seeks to provide data that can help shape future guidelines on sports participation for athletes at risk of serious cardiovascular events.
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Background: The proliferation of e-cigarette content on YouTube is concerning because of its possible effect on youth use behaviors. YouTube has a personalized search and recommendation algorithm that derives attributes from a user's profile, such as age and sex. However, little is known about whether e-cigarette content is shown differently based on user characteristics.

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Approximately 50% of patients who recover from the acute SARS-CoV-2 experience Post Acute Sequelae of SARS-CoV-2 infection (PASC) syndrome. The pathophysiological hallmark of PASC is characterized by impaired system oxygen extraction (EO) on invasive cardiopulmonary exercise test (iCPET). However, the mechanistic insights into impaired EO remain unclear.

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Background Although depression is well established as an independent risk factor for cardiovascular disease (CVD) in the nonpregnant population, this association has largely not been investigated in pregnant populations. We aimed to estimate the cumulative risk of new CVD in the first 24 months postpartum among pregnant individuals diagnosed with prenatal depression compared with patients without depression diagnosed during pregnancy. Methods and Results Our longitudinal population-based study included pregnant individuals with deliveries during 2007 to 2019 in the Maine Health Data Organization's All Payer Claims Data.

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  • Transthyretin amyloid cardiomyopathy (ATTR-CM) is a significant cause of heart failure in older adults, often linked to a specific genetic variant (pV142I) primarily found in individuals of West African descent.
  • The SCAN-MP study aims to determine how prevalent ATTR-CM is in older Black and Caribbean Hispanic patients with heart failure, using noninvasive imaging techniques.
  • This study is the largest of its kind focusing on cardiac amyloidosis in these populations and could lead to better treatment strategies using the approved drug tafamidis.
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Problem: Art- and narrative-based interventions are an integral component of pediatric inpatient psychiatric care. We describe a novel therapeutic comic book we developed for hospitalized children and young adolescents.

Methods: A Hero's Journey is a 38-page zine that can be freely downloaded and photocopied for distribution.

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Background Patients with severe-stage chronic kidney disease (CKD) were excluded from femoropopliteal disease trials evaluating drug-coated balloons (DCBs) and drug-eluting stents (DESs) versus plain balloon angioplasty (POBA) and bare metal stents (BMSs). We examined the interaction between CKD status and device type for the association with 24-month all-cause mortality and major amputation risk. Methods and Results We studied patients undergoing femoropopliteal interventions (September 2016-December 2018) from Medicare-linked VQI (Vascular Quality Initiative) registry data.

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Background: Videolaryngoscopy allows real-time procedural coaching during intubation. This study sought to develop and assess an online curriculum to train pediatric emergency medicine attending physicians to deliver procedural coaching during intubation.

Methods: Curriculum development consisted of semistructured interviews with 12 pediatric emergency medicine attendings with varying levels of airway expertise analyzed using a constructivist grounded theory approach.

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Background The duration and magnitude of increased stroke risk after a hospitalization for acute systolic heart failure (HF) remains uncertain. Methods and Results The authors performed a retrospective cohort study using claims (2008-2018) from a nationally representative 5% sample of Medicare beneficiaries aged ≥66 years. Cox regression models were fitted separately for the groups with and without acute systolic HF to examine its association with the incidence of ischemic stroke after adjustment for demographics, stroke risk factors, and Charlson comorbidities.

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Article Synopsis
  • Pulmonary hypertension (PH) in interstitial lung disease (ILD) leads to higher mortality and reduced physical capacity, with patients showing significantly lower six-minute walk distance and diffusing capacity compared to those with ILD alone.
  • Right heart catheterization is the standard for diagnosing PH, but noninvasive methods, particularly gas-exchange derived pulmonary vascular capacitance (GX), have been identified as effective predictors for distinguishing PH-ILD from non-PH ILD.
  • Using a combination of GX, estimated right ventricular systolic pressure (eRVSP), and FVC/DLCO ratio enhances the accuracy of identifying PH-ILD, achieving a predictive probability of up to 100% when certain thresholds are met.
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Importance: There is a need to better assess the cumulative effect on morbidity and mortality in patients undergoing durable left ventricular assist device (LVAD) implantation. This study evaluates a patient-centered performance metric (days alive and out of hospital [DAOH]) for durable LVAD therapy.

Objective: To determine the incidence of percent of DAOH before and after LVAD implantation and (2) explore its association with established quality metrics (death, adverse events [AEs], quality of life).

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As the worldwide prevalence of overweight and obesity continues to rise, so too does the urgency to fully understand mediating mechanisms, to discover new targets for safe and effective therapeutic intervention, and to identify biomarkers to track obesity and the success of weight loss interventions. In 2016, the American Heart Association sought applications for a Strategically Focused Research Network (SFRN) on Obesity. In 2017, 4 centers were named, including Johns Hopkins University School of Medicine, New York University Grossman School of Medicine, University of Alabama at Birmingham, and Vanderbilt University Medical Center.

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Objectives: Laparoscopic cholecystectomy (LC) at night remains controversial. Prior studies have not controlled for disease severity. We analyzed outcomes of LC performed day vs.

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This study sought to understand education support professionals' (ESPs) experiences early in the COVID-19 pandemic, including how they were feeling about their roles in education, strategies they were using to cope with unprecedented times, barriers they encountered toward maintaining SE health at work, and opportunities they identified as critical for creating safe and supportive school environments. This study employed a convergent parallel (QUAN + QUAL) mixed methods research design to capture ESPs' affective experiences and use of social and emotional learning (SEL). Data were collected in partnership with the National Education Association across 4 weeks through a survey including open and closed-ended questions.

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