Using the Forel-Ule index (FUI) to track the water quality of subsidence water bodies across the life cycle of coal mining in eastern China.

The water quality and associated ecological risks in subsidence water bodies formed by underground coal mining are an increasing global concern. However, long-term water quality changes in these subsidence water bodies, especially across different spatial regions, remain poorly understood. This paper, by mapping the Forel-Ule index (FUI) a key indicator of water color, using Landsat datasets to reveal the dynamic evolution of water quality in 402 subsidence water bodies in the Huang-Huai-Hai Plain of eastern China from 1990 to 2020, covering their life cycle from formation to extinction.

Idiopathic infantile hypercalcemia with a variant triggered by vitamin D supplementation in fortified milk: A case report.

Idiopathic infantile hypercalcemia (IIH) is characterized by hypercalcemia, nephrocalcinosis, vomiting, dehydration, and failure to thrive. It is caused by the presence of biallelic loss-of-function variants in the locus. Although hypercalcemia has been linked to the consumption of vitamin D-fortified milk, no reports have documented its role in triggering IIH in patients with variants.

Factors predictive of serum cortisol in pediatric patients with acute physiological stress: a cohort study.

Measuring cortisol is crucial for assessing adrenal function in patients under stress; however, its value can fluctuate owing to various clinical factors. This study aimed to identify predictors of cortisol levels in pediatric patients with acute physiological stress. Children who were urgently admitted to the general ward or pediatric intensive care unit for acute illness or postoperative care were enrolled, while those with suspected adrenal function abnormalities or on current steroid therapy were excluded.

Identification of a novel missense variant in the gene in a Japanese pedigree with familial neurohypophyseal diabetes insipidus.

Familial neurohypophyseal diabetes insipidus is a rare genetic disease caused by gene variants and is characterized by progressive polyuria and polydipsia in early childhood. Herein, we have reported the clinical symptoms and genetic test results of a Japanese patient with a family history of polyuria and polydipsia for over five generations. The proband was a 6-yr-old boy who was referred for the evaluation of polyuria and polydipsia.

Multifaceted delineation of atrophic thyroiditis among pediatric population: An extensive literature survey.

Autoimmune hypothyroidism is categorized into Hashimoto thyroiditis (HT) and atrophic thyroiditis (AT). Although a consensus exists among Japanese endocrinologists that pediatric AT is associated with severe hypothyroidism, the question remains whether AT and HT are separate conditions. To investigate the clinical characteristics of pediatric AT, we conducted a comprehensive literature review using PubMed and ICHUSHI, a local database.

An emerging fungal disease is spreading across the globe and affecting the blueberry industry.

Powdery mildew is an economically important disease caused by c. 1000 different fungal species. Erysiphe vaccinii is an emerging powdery mildew species that is impacting the blueberry industry.

Neoadjuvant anti-PD-1 alone or in combination with anti-TIGIT or an oncolytic virus in resectable stage IIIB-D melanoma: a phase 1/2 trial.

Neoadjuvant immunotherapies have shown antitumor activity in melanoma. Substudy 02C of the global, rolling-arm, phase 1/2, adaptive-design KEYMAKER-U02 trial is evaluating neoadjuvant pembrolizumab (anti-PD-1) alone or in combination, followed by adjuvant pembrolizumab, for stage IIIB-D melanoma. Here we report results from the first three arms: pembrolizumab plus vibostolimab (anti-TIGIT), pembrolizumab plus gebasaxturev (coxsackievirus A21) and pembrolizumab monotherapy.

Behavioural responses to acute warming precede critical shifts in the cellular and physiological thermal stress responses in a salmonid fish (brook trout, Salvelinus fontinalis).

From a conservation perspective, it is important to identify when sub-lethal temperatures begin to adversely impact an organism. However, it is unclear whether, during acute exposures, sub-lethal cellular thresholds occur at similar temperatures to other physiological or behavioural changes, or at temperatures associated with common physiological endpoints measured in fishes to estimate thermal tolerance. To test this, we estimated temperature preference (15.

The burden of X-linked retinitis pigmentosa (XLRP) on patient experience and patient-reported outcomes (PROs): findings from the EXPLORE XLRP-2 study.

Background/aims: X-linked retinitis pigmentosa (XLRP) is considered one of the most severe forms of retinitis pigmentosa (RP), accounting for 5-15% of all RP cases and primarily affecting males. However, the real-world humanistic impacts of this disease on patients are poorly investigated, especially with respect to burdens faced by patients with varying disease severities.

Methods: EXPLORE XLRP-2 was an exploratory, multicentre, non-interventional study.

Myoclonus After Cardiac Arrest: Need for Standardization-A Systematic Review and Research Proposal on Terminology.

Objectives: Although myoclonus less than or equal to 72 hours after cardiac arrest (CA) is often viewed as a single entity, there is considerable heterogeneity in its clinical and electrophysiology characteristics, and its strength of association with outcome. We reviewed definitions, electroencephalogram, and outcome of myoclonus post-CA to assess the need for consensus and the potential role of electroencephalogram for further research.

Data Sources: PubMed, Embase, and Cochrane databases.

Considering the impact of vaccine communication in the COVID-19 pandemic among adults in Canada: A qualitative study of lessons learned for future vaccine campaigns.

We aimed to understand how experiences with vaccine-related information and communication challenges during the COVID-19 pandemic impacted motivations and behaviors among Canadian adults regarding future vaccines. Semi-structured interviews were conducted with participants purposively selected to ensure diversity in age, sex at birth, self-identified gender, and region. Data were analyzed using thematic analysis; findings were mapped to the Information-Motivation-Behavioral Skills Model focusing on factors affecting vaccine hesitancy and uptake.

Effects of Biological Nitrogen Fixation and Nitrogen Deposition on Soil Microbial Communities in Karst Grassland Ecosystems.

Diverse exogenous nitrogen (N) sources have a considerable impact on microbial community structure in terrestrial ecosystems. Legume plants and N deposition can relieve N limitations and increase net primary productivity. However, the differences in their effects on soil microbial communities remain unclear.

Mitochondrial Genome Assembly and Comparative Analysis of (Oleaceae).

: Lindl. & Paxton is an ornamental tree species native to North China. Research on the mitochondrial genome can elucidate the evolution and biological characteristics of and better protect this important species.

Characteristics of older patients undergoing surgery in the UK: SNAP-3, a snapshot observational study.

Background: Frailty and multimorbidity are common in older adults, but the prevalence and interaction of these conditions in surgical patients remain unclear. This study describes the clinical characteristics of a heterogeneous cohort of older UK surgical patients.

Methods: We conducted a prospective observational cohort study during 5 days in March 2022, aiming to recruit all UK patients aged 60 yr and older undergoing surgery, excluding minor procedures (e.

Impact of Robotic Artificial Urinary Sphincter Implantation in Female Patients on Quality of Life and Patient-reported Outcomes.

Background And Objective: Artificial urinary sphincter (AUS) is commonly used in France in female patients with stress urinary incontinence (SUI) due to intrinsic sphincter deficiency (ISD). However, it has never been assessed using patient-reported outcomes. This study aimed to evaluate the functional outcomes of robotic AUS implantation using validated questionnaires.

Emergy-based valuation of glacier ecosystem services: A case from the Tibetan Plateau.

Glaciers provide multiple ecosystem services (ES) to human society. Due to the continued global warming, the valuation of glacier ES is of urgent importance because this knowledge can support the protection of glaciers. However, a systematic valuation of glacier ES is still lacking, particularly from the perspective of ES contributors.

Guarding Drinking Water Safety against Harmful Algal Blooms: Could UV/Cl Treatment Be the Answer?

Frequent and severe occurrences of harmful algal blooms increasingly threaten human health by the release of microcystins (MCs). Urgent attention is directed toward managing MCs, as evidenced by rising HAB-related do not drink/do not boil advisories due to unsafe MC levels in drinking water. UV/chlorine treatment, in which UV light is applied simultaneously with chlorine, showed early promise for effectively degrading MC-LR to values below the World Health Organization's guideline limits.

Virulence Characterization and Population Structure of f. sp. in Henan Province, China.

Wheat stripe rust, caused by f. sp. (), poses a significant threat to wheat production, particularly in Henan province, which produces more than 36 million tons of wheat grain every year, the highest production among all provinces in China.

The significant role of vegetation activity in regulating wetland methane emission in China.

Accurate quantifying of methane (CH) emissions is a critical aspect of current research on regional carbon budgets. However, due to limitations in observational data, research methodologies, and an incomplete understanding of process mechanisms, significant uncertainties persist in the assessment of wetland CH fluxes in China. In this study, we developed a machine learning model by integrating measured CH fluxes with related environmental data to produce a high-resolution (1 km) dataset of CH fluxes from China's wetlands for the period 2000-2020.

Chronic Myelomonocytic Leukemia with Central Nervous System Involvement in a Dog.

An 8 yr old, male, mixed-breed dog was presented with a 2 mo history of progressive weakness, worsened in the last 2 days before examination. Neurological examination revealed ambulatory tetraparesis, ataxia, and proprioceptive deficits in all four limbs. Menace response was reduced in the right eye and discomfort was detected on neck manipulation.

Microfilaria in the Urine of a Dog with Concurrent Urinary Bladder Sarcoma.

A 12 yr old female spayed American Staffordshire terrier was referred for stranguria, pollakiuria, and concern for a mass in the trigone of the urinary bladder. A urinalysis and abdominal ultrasound were performed to further investigate the bladder mass. Nematode larvae were identified in the urine, termed microfilaruria, while a caudal abdominal mass was found on ultrasound impinging on the urethra.

Long-Term Survival of Primary Intracranial Histiocytic Sarcoma Through Surgical Resection and Low-Dose CCNU.

A 5 yr old chihuahua presented to our clinic with a complaint of decreased activity and focal seizures. Based on the findings of MRI and computed tomography, a primary brain tumor originating from the right frontal lobe region was suspected. Surgical resection was performed, and a diagnosis of histiocytic sarcoma was made via histopathological examination and immunohistochemical staining.

Radiation exposure in patients with inflammatory bowel disease.

Background And Aims: Radiological imaging is crucial for diagnosing and monitoring patients with inflammatory bowel diseases (IBD). With increasing awareness of radiation risks, imaging doses should be 'as low as reasonably achievable', with a risk level that one should try to stay underneath 75 mSv. However, real-world data on cumulative exposure are limited.

Simultaneous determination of twelve microcystins in algal supplements on the Chinese market and possible risks to exposed populations.

Algae supplements are widely recognized for their nutritional benefits and are commonly marketed as natural health products. However, concerns regarding contamination with cyanobacterial toxins have been raised. Moreover, there is very little data regarding the potential contamination of algal supplements on the Chinese market by these toxins.

Heat and Drought Events Alter Biogenic Capacity to Balance CO Budget in South-Western Europe.

Heat and drought events are increasing in frequency and intensity, posing significant risks to natural and agricultural ecosystems with uncertain effects on the net ecosystem CO exchange (NEE). The current Vegetation Photosynthesis and Respiration Model (VPRM) was adjusted to include soil moisture impacts on the gross ecosystem exchange (GEE) and respiration ( ) fluxes to assess the temporal variability of NEE over south-western Europe for 2001-2022. Warming temperatures lengthen growing seasons, causing an increase in GEE, which is mostly compensated by a similar increment in .