Survival outcomes for patients with invasive lobular cancer by MammaPrint: Results from the MINDACT phase III trial.

Background: Evaluation of the prognostic performance and clinical utility of the MammaPrint 70-gene signature in early-stage invasive lobular carcinoma (ILC) for whom such analyses in a randomized trial is awaited.

Patients And Methods: Exploratory subgroup analysis of MINDACT trial patients with centrally assessed histology (n = 5929) with invasive breast cancer of no-special-type (NST), or pure ILC. In the trial patients were categorized based on the 70-gene signature for genomic risk and modified Adjuvant!Online for clinical risk.

A comparative life cycle analysis of bioremediation approaches for old-aged petroleum pollution in hypersaline soil.

Soil oil pollution is a major environmental issue, especially in oil-producing nations, as it threatens the health of plants, animals, and humans. While bioremediation has been extensively utilized as a cost-effective method for restoring oil-contaminated soil, its environmental impact has garnered relatively little attention. Researchers often concentrate on reducing pollutant concentrations below permissible limits to restore soil quality.

Explainable vision transformer for automatic visual sleep staging on multimodal PSG signals.

Polysomnography (PSG) is crucial for diagnosing sleep disorders, but manual scoring of PSG is time-consuming and subjective, leading to high variability. While machine-learning models have improved PSG scoring, their clinical use is hindered by the 'black-box' nature. In this study, we present SleepXViT, an automatic sleep staging system using Vision Transformer (ViT) that provides intuitive, consistent explanations by mimicking human 'visual scoring'.

Diversity and composition of vegetation and soil seed banks after sand dune restoration by oil mulching and plantations.

Soil seed bank (SSB) is valuable reserves of seeds hidden in the soil and are especially important for the preservation and establishment of vegetation under adverse environmental conditions. However, there is a lack of knowledge on the effects of restoration measures on SSB, especially in arid ecosystems. Here, we assess the impacts of oil mulching (1 and 3 years after mulching) and plantations (15-year-old) on the diversity and composition of SSB and aboveground vegetation (AGV) in comparison with those in non-restored areas (i.

Influence of frailty status on the incidence of intraoperative hypotensive events in elective surgery: Hypo-Frail, a single-centre retrospective cohort study.

Background: Frailty is a predictor of morbidity and mortality in older patients. This study aimed to investigate the influence of frailty status on likelihood, rate, duration, and severity of intraoperative hypotension (IOH), which can lead to severe organ dysfunction.

Methods: Surgical patients (≥70 yr old) with preoperative frailty assessment were analysed retrospectively.

Influence of precipitation and temperature variability on anthropogenic nutrient inputs in a river watershed: Implications for environmental management.

Since the Industrial Revolution, anthropogenic activities have substantially increased the input of nitrogen (N) and phosphorus (P) into river watersheds, exacerbated by uncertainties stemming from climate change. This study provided a detailed analysis of N and P inputs within the Dawen River Watershed in China from 2000 to 2021. The Net Anthropogenic Nitrogen Input (NANI) and Net Anthropogenic Phosphorus Input (NAPI) methods were used in study, which aimed to investigate how they respond to various climate change factors.

Species Diversity, Biomass Production and Carbon Sequestration Potential in the Protected Area of Uttarakhand, India.

Ecosystem functioning and management are primarily concerned with addressing climate change and biodiversity loss, which are closely linked to carbon stock and species diversity. This research aimed to quantify forest understory (shrub and herb) diversity, tree biomass and carbon sequestration in the Binsar Wildlife Sanctuary. Using random sampling methods, data were gathered from six distinct forest communities.

Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise.

Methylsulfonylmethane (MSM) is a sulfur-containing molecule with reported anti-inflammatory and antioxidant activities. Exercise causes the formation of free radicals and stimulates inflammatory gene expression in leukocytes and skeletal muscle. The hypothesis that dietary supplementation with MSM alters the exercise-mediated inflammatory and oxidant response was assessed in unfit adult thoroughbred geldings.

Evolving Trends and Patterns of Utilization of Magnetic Resonance-Guided Radiotherapy at a Single Institution, 2018-2024.

: Over the past decade, significant advances have been made in image-guided radiotherapy (RT) particularly with the introduction of magnetic resonance (MR)-guided radiotherapy (MRgRT). However, the optimal clinical applications of MRgRT are still evolving. The intent of this analysis was to describe our institutional MRgRT utilization patterns and evolution therein, specifically as an early adopter within a center endowed with multiple other technology platforms.

Tiragolumab in combination with atezolizumab and bevacizumab in patients with unresectable, locally advanced or metastatic hepatocellular carcinoma (MORPHEUS-Liver): a randomised, open-label, phase 1b-2, study.

Background: PD-L1 and VEGF blockade with atezolizumab plus bevacizumab has been shown to improve survival in unresectable hepatocellular carcinoma. TIGIT is an immune checkpoint regulator implicated in many cancers, including unresectable hepatocellular carcinoma. Here, we evaluate the clinical activity and safety of the addition of tiragolumab, an anti-TIGIT monoclonal antibody, to atezolizumab plus bevacizumab.

Twenty years of studying the origins and fate of atmospheric mercury over the Mediterranean Sea.

This study provides a review of 13 oceanographic campaigns between 2000 and 2017 to measure Hg in the Mediterranean, highlighting major findings from measurement and modelling activities during the Med-Oceanor program. The initial campaigns showed that high concentrations of RGM could be found far from industrial source regions and the observed daily variation in concentration, with peaks at midday and lower concentrations during darkness gave the first indications that photochemically mediated oxidation reactions were producing RGM in the MBL. Later atmospheric chemistry modelling studies showed the feasibility of Hg oxidation by bromine containing oxidants, which are released as a result of the acidification of sea salt aerosols in the Marine Boundary Layer (MBL).

Multidimensional 1-Year Outcomes After Intensive Care Admission for Multisystem Inflammatory Syndrome in Children.

Objectives: The COVID-19 pandemic gave rise to uncertainty concerning potential sequelae related to a severe acute respiratory syndrome coronavirus 2 infection. This landscape is currently unfolding with studies reporting sequelae on various domains (physical, cognitive, and psychosocial), although most studies focus on adults or only one domain. We sought to investigate concurrent sequelae on multiple domains 1 year after PICU admission for Multisystem Inflammatory Syndrome in Children (MIS-C).

Toward the Limits of Human Ageing Physiology: Characteristics of the 50-, 60- and 70-yr + Male Indoor Rowing World Champions.

Purpose: To examine the physiological, power-duration, nutritional intake and training characteristics of the recent lightweight (- 75 kg) 50+, 60+ and 70 + yr world champion indoor rowers.

Methods: Laboratory assessments, undertaken over 2 visits, examined body composition, pulmonary function, blood lactate/ventilatory landmarks, efficiency, fat/carbohydrate oxidation, primary component time-constant to steady-state [𝜏pc]) and peak oxygen consumption (V̇O2peak). Training, performance and nutritional intake were also reported.

A pharmacokinetic/pharmacodynamic analysis of intravenous tranexamic acid in adult patients undergoing elective total hip arthroplasty (ORACLE).

Background: Uncertainty about optimal tranexamic acid (TXA) dosage has led to significant practice variation in hip arthroplasty. We aimed to identify the optimal i.v.

Prevalence, Diagnosis, and Management of Stress Urinary Incontinence in Women: A Collaborative Review.

Background And Objective: Stress urinary incontinence (SUI), defined as any involuntary leakage of urine associated with physical activity, remains underdiagnosed and undertreated. This review aims to provide an updated overview of the prevalence, diagnosis, and treatment of SUI in women, drawing upon recent evidence-based literature and clinical guidelines.

Methods: A systematic search of the MEDLINE database was conducted to identify only the most up-to-date and relevant studies published up to February 26, 2024, including the reference ESTER systematic review.

Incidence and Outcomes of Secondary Bladder Cancer Following Radiation Therapy for Prostate Cancer: A Systematic Review and Meta-analysis.

Background And Objective: There is an established association between secondary bladder cancers (SBCs) and radiotherapy (RT) for prostate cancer (PC), which remains a significant concern. Our aim was to update the evidence on SBC incidence across different RT modalities and to compare oncological outcomes for patients diagnosed with SBC to those diagnosed with primary bladder cancer (PBC).

Methods: We searched MEDLINE, Scopus, and Web of Science for studies on SBC following PC.

Association of systemic inflammatory markers with white matter hyperintensities and microstructural injury: an analysis of UK Biobank data.

Background: White matter damage is closely associated with cognitive and psychiatric symptoms and is prevalent in cerebral small vessel disease (CSVD); although the pathophysiological mechanisms involved in CSVD remain elusive, inflammation plays a crucial role. We sought to investigate the relationship between systemic inflammation markers and imaging markers of CVSD, namely white matter hyperintensity (WMH) and microstructural injury.

Methods: We conducted a study involving both cross-sectional and longitudinal data from the UK Biobank Cohort.

Quantification of Fugitive Carbon Emissions from Uncontrolled Combustion in Coal Fire Area: the Sandaoba Coalfield, Xinjiang, China.

Spontaneous coal fires are a significant source of greenhouse gas emissions, contributing to global warming. However, the lack of reliable estimation methods and research has obscured the full environmental impact of these emissions. This paper presents a novel quantification method for fugitive carbon emissions from spontaneous coal combustion.

National scale evaluation of nutrient purification capacity in marine sediments along the coast of South Korea: A mesocosm study based in situ assessment.

The ecosystem regulating services from tidal flats, such as removal of organic pollutants, provided by natural tidal flats are being increasingly recognized, yet quantitative evaluation remains limited. Here we evaluated a nationwide capacity of natural purification in tidal flats. Using in situ sediments from five along the Korean coast (Incheon, Gunsan, Sinan, Gwangyang, and Busan), we applied a mesocosm system informed by 18 years of riverine monitoring data from national surveys.

Tidal-driven NO emission is a stronger resister than CH to offset annual carbon sequestration in mangrove ecosystems.

The mangrove ecosystems store a significant amount of "blue carbon" to mitigate global climate change, but also serve as hotspots for greenhouse gases (GHGs: CO, CH and NO) production. The CH and NO emissions offset mangrove carbon benefits, however, the extent of this effect remains inadequately quantified. By applying the 36 h time-series observations and mapping cruises, here we investigated the spatial and temporal distribution of GHGs and their fluxes in Dongzhaigang (DZG) bay, the largest mangrove ecosystem in China, at tidal and monthly scales.

Ecosystem water use efficiency and carbon use efficiency respond oppositely to vegetation greening in China's Loess Plateau.

Ecosystem water use efficiency (WUE) and carbon use efficiency (CUE) are critical parameters to determine the trade-off between water consumption and carbon sequestration in drylands. However, the roles of vegetation cover, climate factors and soil moisture in affecting the coupling of WUE and CUE were still poorly understood. This study combined the spatial random forest model and structural equation model to detect the drivers of WUE and CUE variations in China's Loess Plateau during 2001-2020, a typical water-limited region with about 87 % of area experiencing significant vegetation greening.

Cushing's syndrome related to higher rates and earlier onset of cataract: A nationwide retrospective cohort study.

Purpose: To investigate the risk of cataract in patients with Cushing's syndrome (CS) and evaluate whether disease onset occurs at an earlier age compared to general population.

Methods: A nationwide retrospective matched-cohort study including individuals diagnosed with endogenous CS from 2000 to 2023. Patients with CS were matched in a 1:5 ratio with a control group individually matched for age, sex, socioeconomic status, and body mass index.

Repeatability and Validity of Different Methods to Determine the Anaerobic Threshold Through the Maximal Multistage Test in Male Cyclists and Triathletes.

: The aim of this study was to analyze the repeatability and validity of different methods to determine the anaerobic threshold through a maximal multistage cycling test; : In total, 17 male endurance-trained athletes [7 cyclists and 10 triathletes, age 33.2 ± 6.9 yr, workload at maximal lactate steady state (MLSS) 268 ± 27 W] participated in the study.

Bone imaging modality precision and agreement between DXA, pQCT, and HR-pQCT.

Quantifying precision error for DXA, peripheral QCT (pQCT), and HR-pQCT is crucial for monitoring longitudinal changes in body composition and musculoskeletal outcomes. Agreement and associations between bone variables assessed using pQCT and second-generation HR-pQCT are unclear. This study aimed to determine the precision of, and agreement and associations between, bone variables assessed via DXA, pQCT, and second-generation HR-pQCT.

Impact of Surgical Margin Status and Tumor Volume on Mortality After Robotic Radical Prostatectomy.

Background And Objective: Positive surgical margins (PSMs) following radical prostatectomy (RP) have been seen as inherently unfavorable. However, a large international multi-institutional study recently revealed that unifocal PSMs (UPSMs) had no impact on prostate cancer-specific mortality (PCSM), whereas multifocal PSMs (MPSMs) did. Our aim was to assess the relative impact of PSMs versus percentage tumor volume (PTV) on PCSM.