The impact of rhythm perception on chest compression rate during CPR: Insights from a pilot simulation study.

Objective: This pilot study aims to assess how individuals with rhythm perception, particularly musicians, are able to maintain the predefined chest compression rate during cardiopulmonary resuscitation compared to people without rhythm perception.

Methods: The study was conducted at the Pilsen Emergency Medicine Conference (Czechia) using a simulation-based cohort design. Participants performed chest compressions on a manikin for 120 s, with the first 10 s guided by a metronome.

Thiamine-Reduced Fatigue in Quiescent Inflammatory Bowel Disease Is Linked to Abundance.

Background And Aims: Chronic fatigue is common in patients with inflammatory bowel disease (IBD). The gut microbiota, specifically, microbial diversity and butyrate-producing bacteria have been linked to the fatigue pathogenesis. High-dose oral thiamine reduces fatigue, potentially through gut microbiota modification.

Twins with at least one with CHD and their immunisation status in direct comparison-are both twins complying with the German immunisation recommendations?

Background: Patients with congenital heart defects (CHDs) are at higher risk for infectious diseases. This may partly be due to frequent hospital stays and the associated exposure to pathogens. This study aims to provide a comprehensive overview of immunisation coverage among twins in which at least one twin has CHD.

Pregnancy & cardiovascular disease: the PREG-CVD-HH registry.

Background: Cardiovascular disease (CVD) remains the leading cause of death in pregnant and peripartal women in western countries. Physiological changes during pregnancy can lead to cardiovascular complications in the mother; women with pre-existing heart disease may not tolerate these changes well, increasing their susceptibility to adverse cardiovascular outcomes during pregnancy. The aim of this study is to characterize pregnancy-induced changes in cardiac function, biomarker concentrations and cardiovascular outcomes in women with CVD during pregnancy at a tertiary care hospital in Germany.

Domain-Specific Prediction of Clinical Progression in Parkinson's Disease Using the Mosaic Approach.

Purpose: Due to the highly individualized clinical manifestation of Parkinson's disease (PD), personalized patient care may require domain-specific assessment of neurological disability. Evidence from magnetic resonance imaging (MRI) studies has proposed that heterogenous clinical manifestation corresponds to heterogeneous cortical disease burden, suggesting customized, high-resolution assessment of cortical pathology as a candidate biomarker for domain-specific assessment.

Method: Herein, we investigate the potential of the recently proposed Mosaic Approach (MAP), a normative framework for quantifying individual cortical disease burden with respect to a population-representative cohort, in predicting domain-specific clinical progression.

Pacific Proving Grounds-Derived U and U: Potential Tracers for Western North Pacific Ocean Dynamics.

U and U are proven to be useful tracers to investigate upper-ocean hydrodynamics due to their source-specific isotopic ratios and conservative behaviors in the open ocean. However, their application in the Pacific Ocean has been limited by scarce observations and unclear source-term information. Here, we present our observations of U and U in the western North Pacific Subtropical Gyre (NPStG), showing the presence of a source of anthropogenic U featured by a low U/U ratio (∼1 × 10), which is an order of magnitude lower than the global fallout signature (∼2 × 10).

Best Evidence Summary for the Improvement and Management of Disorders of Consciousness in Patients With Severe Brain Injury.

Background And Purpose: The treatment effect of consciousness after brain injury is currently uncertain. Thus, this study aimed to retrieve the evidence from neurologists around the world on the management of consciousness disorders in patients with severe brain injury and evaluate and summarize the evidence, providing the guidance on the related management for clinicians.

Methods: Following the evidence summary report standard of Fudan University Center for Evidence-Based Nursing, clinical guidelines, expert consensuses, systematic reviews, and evidence summaries were systematically retrieved from UpToDate; BMJ Best Practice; Guidelines International Network; the Cochrane Library; Embase; PubMed; Sinomed; Web of Science; CNKI; WanFang database; American Academy of Neurology (AAN); American Congress of Rehabilitation Medicine (ACRM); European Academy of Neurology; and National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR).

Apnet: Lightweight network for apricot tree disease and pest detection in real-world complex backgrounds.

Apricot trees, serving as critical agricultural resources, hold a significant role within the agricultural domain. Conventional methods for detecting pests and diseases in these trees are notably labor-intensive. Many conditions affecting apricot trees manifest distinct visual symptoms that are ideally suited for precise identification and classification via deep learning techniques.

Pre-processing of paleogenomes: mitigating reference bias and postmortem damage in ancient genome data.

We investigate alternative strategies against reference bias and postmortem damage in low coverage paleogenomes. Compared to alignment to the linear reference genome, we show that masking known polymorphic sites and graph alignment effectively remove reference bias, but only starting from raw read files. We next study approaches to overcome postmortem damage: trimming, rescaling, and our newly developed algorithm, bamRefine (github.

Effectiveness of a comic book intervention on mental health literacy among adolescents and youth in Burkina Faso: a randomized controlled trial protocol.

Background: In Burkina Faso, nearly half of the population is under 15 years old, and one in four adolescents experience depression. This underscores the critical need to enhance mental health literacy among adolescents and youth, empowering them to manage their mental well-being effectively. Comic books offer an engaging approach to health education, yet their effectiveness in addressing mental health remains largely untested.

Suture button systems for coronoid fracture fixation: a biomechanical time-zero pilot study.

Purpose: This study aims to describe a fixation technique for coronoid fractures using suture buttons, and to biomechanically evaluate this technique in comparison to screw fixation as a time-zero pilot study.

Methods: An O'Driscoll type 2 anteromedial coronoid facet (AMCF) fracture was simulated in 20 fresh-frozen human elbows. The specimens were randomized into two groups and fracture fixation was performed with either a suture button system or a 3.

Automated stenosis estimation of coronary angiographies using end-to-end learning.

The initial evaluation of stenosis during coronary angiography is typically performed by visual assessment. Visual assessment has limited accuracy compared to fractional flow reserve and quantitative coronary angiography, which are more time-consuming and costly. Applying deep learning might yield a faster and more accurate stenosis assessment.

Advanced control parameter optimization in DC motors and liquid level systems.

In recent times, there has been notable progress in control systems across various industrial domains, necessitating effective management of dynamic systems for optimal functionality. A crucial research focus has emerged in optimizing control parameters to augment controller performance. Among the plethora of optimization algorithms, the mountain gazelle optimizer (MGO) stands out for its capacity to emulate the agile movements and behavioral strategies observed in mountain gazelles.

Construction of molecular structure model of bituminous coal and study on adsorption characteristics of CH and CH.

The abandoned coal in goaf will adsorb the gases ethylene (CH) and acetylene (CH) produced by coal oxidation, which makes the concentration data of the indicator gas inaccurate. Therefore, the adsorption law of coal and CH and CH gas is explored. The macromolecular structure model of coal was established and optimized by simulation, and the gas adsorption process was simulated by means of grand canonical Monte Carlo method.

Research on the optimization of drum structure based on virtual prototyping technology.

Drums are the core working mechanism of the coal mining machine for coal mining. The structural design level of the drum is crucial for mining efficiency and safety production. Traditional design methods not only have long design cycles and high costs, but also limited design capabilities.

A double closed loop digital hydraulic cylinder position system based on switching active disturbance rejection control.

A switching active disturbance rejection control (SADRC) strategy was proposed to solve the composite disturbance challenge arising from gap, LuGre friction, hydraulic spring force, and external load disturbance in the double closed-loop digital hydraulic cylinder position control system. Firstly, leveraging the established mathematical model of the double closed-loop digital hydraulic cylinder, the high-order state equation was derived. Subsequently, the high-order double closed-loop digital hydraulic cylinder control system was transformed into a second-order integral series control system using ADRC strategy.

The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization.

Although sex determination is a fundamental process in vertebrate development, it is very plastic. Diverse genes became major sex determinants in teleost fishes. Deciphering how individual sex-determining genes orchestrate sex determination can reveal new actors in sexual development.

Virtual reality-based neuroproprioceptive physiotherapy in multiple sclerosis: a protocol for a double-arm randomised assessor-blinded controlled trial on upper extremity function, postural function and quality of life, with molecular and functional MRI assessment.

Introduction: Upper limb (UL) impairment is common in people with multiple sclerosis (pwMS), and functional recovery of the UL is a key rehabilitation goal. Technology-based approaches, like virtual reality (VR), are increasingly promising. While most VR environments are task-oriented, our clinical approach integrates neuroproprioceptive 'facilitation and inhibition' (NFI) principles.

Assessing Internalized Beliefs: Psychometric Evidences for the Pathogenic Belief Scale in Turkish Culture.

This study was conducted to test the reliability and validity of the Pathogenic Belief Scale (PBS) on adult individuals. Participants consisted of 299 adults, including 189 (63.2%) females and 110 (36.

Exploring in vitro efficacy of rCHAPk with antibiotic combinations, and promising findings of its therapeutic potential for clinical-originated MRSA wound infection.

The increasing threat of antimicrobial-resistant bacteria, particularly Staphylococcus aureus, which rapidly develops multidrug resistance and commonly colonizes wound surfaces, demands innovative strategies. Phage-encoded endolysins offer a dual-purpose approach as topical therapies for infectious skin wounds and synergistic agents to reduce high-dose antibiotic dependence. This study explores recombinant CHAPk (rCHAPk), efficiently synthesized within 3 h, displaying broad-spectrum antibacterial activity against 10 Gram-positive strains, including resistant variants, with rapid bactericidal kinetics.

What motivates critical care nurses to stay in their job? - Structural aspects for empowering intrinsic motivation in permissive professional contexts: A scoping review.

Objective: In the wake of the COVID-19 pandemic, a significant number of critical care nurses have left their positions, citing overload, burnout, and moral distress. This scoping review is not just a theoretical exploration but a timely and crucial investigation into the aspects and structures of critical care nursing that can make the job fulfilling and appealing, thereby promoting intrinsic motivation and staff retention.

Methodology: A scoping review of studies reporting on factors that allow critical care nurses to fall back on their intrinsic job motivation.

A gender breakdown of unexpected benefits generated by work from home in STEM fields - A qualitative analysis of the WiMPBME Task Group survey.

Background: Working from home during the Covid-19 pandemic was perceived differently by men and women working in STEM fields. The aim of this paper is to highlight the unexpected benefits generated by working from home during the pandemic.

Methods: Qualitative methodology was used to analyze data, collected via survey.

Neural network surrogate and projected gradient descent for fast and reliable finite element model calibration: A case study on an intervertebral disc.

Accurate calibration of finite element (FE) models is essential across various biomechanical applications, including human intervertebral discs (IVDs), to ensure their reliability and use in diagnosing and planning treatments. However, traditional calibration methods are computationally intensive, requiring iterative, derivative-free optimization algorithms that often take days to converge. This study addresses these challenges by introducing a novel, efficient, and effective calibration method demonstrated on a human L4-L5 IVD FE model as a case study using a neural network (NN) surrogate.

Heavy metal(loid)s accumulation and human health risk assessment in wheat after long-term application of various urban and rural organic fertilizers.

Composting urban and rural wastes into organic fertilizers for land application is considered the best way to dispose of and recycle waste resources. However, there are some concerns about the long-term effects of applying various organic fertilizers on soils, food safety, and health risks derived from heavy metal(loid)s (HMs). A long-term field experiment was conducted to evaluate the effects of continuous application of chicken manure compost (CM), sewage sludge compost (SSC), and domestic waste compost (DWC) for wheat on the accumulation, transfer, and health risks of HMs.