Prognostic Value of CXCL13, CCL11, and CCL20 Chemokines in Multiple Sclerosis.

The course of relapsing-remitting multiple sclerosis (RRMS) is highly variable and there is a lack of effective prognostic biomarkers. This study aimed to assess the potential prognostic value of the chemokines B lymphocyte chemoattractant molecule (CXCL13), eotaxin-1 (CCL11), and macrophage inflammatory protein 3-alpha (CCL20) in RRMS. Forty-two patients with MS were enrolled, along with 22 controls, 12 of the controls were idiopathic intracranial hypertension (IIH) patients, and 10 of the controls were other neurologic diseases (OND).

Vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) Hysterectomy with Two Previous Renal Transplantations: The First Case in the Literature Two Renal Transplants.

This study demonstrates the feasibility of performing a Transvaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) hysterectomy on a patient with a complex surgical history, including two renal transplants. The case involves a 42-year-old female presenting with persistent menorrhagia and hypermenorrhea, unresponsive to standard treatments, and diagnosed with adenomyosis and CIN3. A detailed, step-by-step procedure of the vNOTES technique is provided, marking the first video article to document vNOTES hysterectomy in such a medical context.

A New Risk Prediction Model for the Assessment of Myocardial Injury in Elderly Patients Undergoing Non-Elective Surgery.

Currently, recommended pre-operative risk assessment models including the revised cardiac risk index (RCRI) are not very effective in predicting postoperative myocardial damage after non-elective surgery, especially for elderly patients. This study aimed to create a new risk prediction model to assess myocardial injury after non-cardiac surgery (MINS) in elderly patients and compare it with the RCRI, a well-known pre-operative risk prediction model. This retrospective study included 370 elderly patients who were over 65 years of age and had non-elective surgery in a tertiary hospital.

Evaluation of urinary density as a biomarker for the diagnosis of acute heart failure.

Background: Heart failure (HF) has become a public healthcare concern with significant costs to countries because of the aging world population. Acute heart failure (AHF) is a common condition faced frequently in emergency departments, and patients often present to hospitals with complaints of breathlessness. The patient must be evaluated with anamnesis, physical examination, blood, and imaging results to diagnose AHF.

Deep Learning Enabled Scoring of Pancreatic Neuroendocrine Tumors Based on Cancer Infiltration Patterns.

Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous group of neoplasms that include tumors with different histomorphologic characteristics that can be correlated to sub-categories with different prognoses. In addition to the WHO grading scheme based on tumor proliferative activity, a new parameter based on the scoring of infiltration patterns at the interface of tumor and non-neoplastic parenchyma (tumor-NNP interface) has recently been proposed for PanNET categorization. Despite the known correlations, these categorizations can still be problematic due to the need for human judgment, which may involve intra- and inter-observer variability.

The effect of caffeic acid phenethyl ester on facial nerve regeneration.

Background: Caffeic acid phenethyl ester (CAPE), an active component of honey bee propolis, has been demonstrated in animal models and studies to have anti-inflammatory, antioxidant, immunomodulatory, neuroprotective, and cytoprotective properties.

Objective: We investigated the efficacy of CAPE, which we believe may be therapeutically useful in facial nerve restoration due to its neuroprotective and antioxidant properties.

Material And Methods: 20 Sprague Dawley rats were divided randomly into 4 primary and 2 secondary groups and assigned as control, methylprednisolone, CAPE, CAPE+methylprednisolone groups and the sham and the trauma groups.

Challenges and effectiveness of remote neurological follow-up of children with concussion following TBI using telemedicine.

Background: Traumatic brain injury (TBI) in children, including concussion, is one of the major causes of emergency department (ED) registration and a significant burden on the health system.

Objectives: The primary goal of this study was to evaluate the outcomes of a telemedicine strategy for remotely monitoring the children with traumatic brain concussions, focusing on their neurological symptoms and signs. The secondary goal was to explore socioeconomic and educational differences among the participating families.

Effect of Finger Socks on Clinical Cure in Interdigital Tinea Pedis.

Background: Humidity between the toes and occlusion are risk factors and causes of recurrence for interdigital tinea pedis.

Objective: To determine the role of wearing "finger-socks" in addition to topical antifungal treatment in managing interdigital tinea pedis.

Methods: Among 54 patients with interdigital tinea pedis confirmed by direct microscopy, 31 in the study group were recommended to wear five-finger socks in addition to topical antifungal treatment for four weeks, while 23 in the control group received only topical antifungal treatment without sock recommendations.

Witteveen-Kolk Syndrome With Cleft Palate: A Case Report and Review of the Literature.

Witteveen-Kolk syndrome (WITKOS) is an exceptionally uncommon genetic and neurodevelopmental disorder, characterized by developmental delay, mild intellectual disability, and craniofacial dysmorphic features. Although cleft palate (CP) has rarely been reported in WITKOS, CP in this condition has not been assessed in detail. Here, we present a case of WITKOS with a CP.

Knowledge, attitudes, and anxiety levels of parents with suspected COVID-19 children: A cross-sectional study in Turkey.

Objective: To determine the knowledge, attitudes and anxiety levels of parents with children suspected of having coronavirus disease-2019.

Methods: The descriptive, cross-sectional study was conducted at the coronavirus disease-2019 outpatient clinic of a tertiary hospital in Ankara, Turkey, between January and August 2021, and comprised parents who presented with suspicions of coronavirus disease-2019 in their children. Data was collected using a questionnaire to assess the parents' knowledge and attitudes towards coronavirus disease-2019, the State-Trait Anxiety Inventory-I and the visual analogue scale to determine levels of fear related to coronavirus disease-2019.

Impact of different glycoprotein IIb/IIIa inhibitor infusion routes on infarct size and microvascular obstruction in patients with high thrombotic risk ST elevation myocardial infarction.

Objective: Current guidelines recommend the use of glycoprotein IIb/IIIa (GpIIb/IIIa) inhibitors in patients with ST-segment elevation myocardial infarction (STEMI) only as a bail-out therapy. However, drug penetration to the jeopardised area may not be achieved due to impeded blood flow and increased microvascular resistance. Aim of our study is to investigate the impact of distal intracoronary GpIIb/IIIa inhibitor agent infusion in STEMI patients.

Predictive importance of cartilage acetabular index for acetabular dysplasia in orthopedic surgery.

Purpose: To investigate the relationship between the cartilage acetabular index and acetabular development and secondary dysplasia.

Methods: A total of 58 hips underwent intraoperative arthrography-guided open reduction or limited open reduction due to developmental hip dysplasia between 2011 and 2015 was included in the study. We evaluated patients with acetabular angle 8º as group 2.

Lateral center-edge angle in femoroacetabular impingement: from the sourcil or the rim of the acetabulum?

The correlation between clinical outcomes and preoperative/postoperative measures of the lateral center-edge angle (LCEA) will help establish the cutoff values for this measurement and determine whether to obtain it from the lateral acetabular rim (LCEAR) or the lateral end of the sourcil (LCEAS). The hypothesis was that the LCEAS would be more sensitive than the LCEAR. An upper cutoff value of LCEA could predict better functional outcomes in FAI patients.

Can erector spinae plane block replace intrathecal morphine in cesarean section? A prospective randomized controlled study on opioid consumption.

Objectives: After cesarean, optimal analgesia is important for early mobilization, mitigating thromboembolic risks, and mother-infant communication. Our study aims to compare the postoperative analgesic effects of intrathecal morphine (ITM) and Erector Spinae Plane Block (ESPB) in elective cesarean section under spinal anesthesia.

Methods: 82 patients were randomized into ESPB and ITM groups.

The impact of uric acid levels in the pathophysiology and its contribution to the prediction of diagnosis in restless legs syndrome.

Restless legs syndrome (RLS) is characterized by an uncomfortable urge to move the legs, worsened in the evening, occurring at rest, and relieved temporarily by movement. Although its pathophysiology remains incompletely understood, oxidative stress has been suggested. Uric acid (UA) is a marker associated with oxidative stress, and its reduced levels pose a risk for certain neurodegenerative diseases.

Comparison of Coconut and Sunflower Seed Oils in Improving the Skin Integrity and Weight Gain of Infants in the Neonatal ICU.

Objective: To determine the effects of sunflower seed oil and coconut oil on the skin integrity and weight gain of preterm infants in the neonatal ICU.

Methods: In this randomized controlled trial, 66 preterm neonates (34-37 weeks' gestation) in the neonatal ICU of a training and research hospital were equally divided into three groups: sunflower seed oil, coconut oil, and control. The weights of neonates in all three groups were measured at admission to the neonatal ICU, at discharge, and at 1 month postdischarge.

Surgical treatment of a giant hydatid cyst in the interventricular septum.

The surgical procedure detailed in this case report focuses on the treatment of a large cardiac hydatid cyst located in the intraventricular septum. The surgical intervention comprised a comprehensive approach involving a median sternotomy and cardiopulmonary bypass. A localized mass below the tricuspid valve at the basal region of the interventricular septum was revealed.

Is obstructive sleep apnea syndrome a risk factor for floppy eyelid syndrome? A multicenter study.

Objective: Evaluate the relationship between OSAS and floppy eyelid syndrome [FES], along with possible confounding factors such as gender, age, and BMI.

Methods: This was a multicenter, cross-sectional prospective study. Patients referred to the sleep clinic suspected of OSAS were included in the study.

Evaluation of the Usability of ChatGPT-4 and Google Gemini in Patient Education About Rhinosinusitis.

Introduction: Artificial intelligence (AI) based chat robots are increasingly used by users for patient education about common diseases in the health field, as in every field. This study aims to evaluate and compare patient education materials on rhinosinusitis created by two frequently used chat robots, ChatGPT-4 and Google Gemini.

Method: One hundred nine questions taken from patient information websites were divided into 4 different categories: general knowledge, diagnosis, treatment, surgery and complications, then asked to chat robots.

Predictive Value of Inflammatory Scores for Left Atrium Thrombosis in Ischemic Stroke Without Atrial Fibrillation.

: Studies have shown that inflammation markers can be used as prognostic tools in predicting acute ischemic stroke. In this study, we conducted a comparison of several inflammation scores in predicting left atrial thrombosis (LAT) in patients with ischemic stroke without AF. : In this single-center, retrospective study, we included 303 consecutive patients with ischemic stroke.

The Utilization of Acetaminophen for Managing PGE1-Induced Fever in Neonates with Critical Congenital Heart Disease.

Introduction: We aimed to retrospectively evaluate the use of acetaminophen, which may be a risk factor for the ductal canal, in the treatment of fever due to prostaglandin E1 (PGE1) infusion in newborns with critical congenital heart disease (CCHD).

Methods: The study included newborns who were followed-up in our neonatal intensive care unit with the diagnosis of critical congenital heart disease, developed fever due to PGE1 infusion and had acetaminophen administered for antipyretic treatment. The patent ductus arteriosus diameters of the patients were evaluated by echocardiographic imaging before intravenous acetaminophen treatment and at the end of the day of acetaminophen treatment.

Diagnosis of Multiple Organ Dysfunction in Neonates with Hypoxic-Ischemic Encephalopathy: Vasoactive Inotropic Score, Renal Score, Fibrosis-5 Index and Lactate/Albumin Ratio.

Background: Vasoactive inotrope score, renal score, fibrosis-5 index, and lactate-albumin ratio have not been investigated before in determining multiple organ dysfunctions accompanying infants with hypoxic-ischemic encephalopathy (HIE) in neonatal intensive care units (NICUs). The aim of this study was to determine whether multiple organ dysfunctions that may accompany HIE in infants are correlated with vasoactive inotrope score (VIS), renal score (RS), fibrosis-5 index (FIB-5), and lactate-albumin ratio (LAR), and whether these parameters can predict morbidity and mortality.

Methods: This is a retrospective study, and 106 newborns diagnosed with HIE and treated with hypothermia were included in the study.

Vascular Injury of Penetrating Trauma of the Extremities.

Physical examination and computed tomography angiography (CTA) are used for diagnosing arterial injury in extremity trauma. In recent years, CTA has been overused to obtain more objective data. Our study aimed to investigate the effect of using CTA for the management of patients with extremity penetrating injuries, specifically in cases where vascular injury was not detected during initial examination.

The Association of Sarcopenia and Body Composition With Benign Positional Paroxysmal Vertigo in Older Adults.

Objectives: One-third of older adults suffer from dizziness and vertigo. Benign positional paroxysmal vertigo (BPPV), which occurs due to otoconia moving into the semicircular canal, is the most common vestibular disorder. We evaluated the connection between BPPV and geriatric symptoms.

Microsurgical Resection of a Midbrain Cavernous Malformation via the Paramedian Supracerebellar Infratentorial Translateral Mesencephalic Sulcus Approach Using the Dynamic Lateral Semisitting Position: Two-Dimensional Operative Video with 3-Dimensional Anatomical Models.

Brainstem cavernous malformations are relatively rare lesions with a higher tendency of hemorrhage than supratentorial cavernous malformations. Due to the compact arrangement of fiber tracts and nuclei of the region, any hemorrhagic event can cause severe neurological deficits. This eloquent architecture of the area also makes any surgical attempt challenging.