LFC131 peptide-conjugated polymeric nanoparticles for the effective delivery of docetaxel in CXCR4 overexpressed lung cancer cells.

CXCR4 is a chemokine receptor which is over expressed in multiple cancers including lung cancers. LFC131 peptide (d-Tyr-Arg-Arg-2-Nal-Gly), an inhibitor of CXCR4-ligand binding, is a low molecular weight CXCR4 antagonist. In this study, we developed novel LFC131 peptide surface conjugated O-carboxymethyl chitosan nanoparticles (O-CMC NP) to target CXCR4 over expressed A549 lung cancer cells.

Association of X-ray repair cross-complementing group 1 promoter rs3213245 polymorphism with lung cancer risk.

X-ray repair cross-complementing group 1 (XRCC1) is a major DNA repair protein in the base excision repair pathway. XRCC1 rs3213245 is a functional polymorphism in the XRCC1 gene promoter region which results in decreased DNA repair capacity. Previous studies investigating the association of XRCC1 rs3213245 polymorphism with lung cancer risk reported conflicting results.

Inhibition of SENP1 induces radiosensitization in lung cancer cells.

Lung cancer is one of the most common and lethal types of malignancy. To date, radiotherapy and chemotherapy have been used as the two major treatment methods. However, radioresistance of lung cancer remains a therapeutic hindrance.