Efficacy and safety of a live attenuated influenza vaccine in Chinese healthy children aged 3-17 years in one study center of a randomized, double-blind, placebo-controlled phase 3 clinical trial, 2016/17 season.

Background: No data on the safety and efficacy of a live attenuated influenza vaccine in China have ever been reported.

Methods: At a site of a phase 3 randomized, double-blind, placebo-controlled clinical trial in eastern China, eligible healthy children aged 3-17 years underwent randomization to receive live attenuated vaccine or placebo at a ratio of 1:1. The primary objective of the study was the prevention of laboratory-confirmed influenza illness during the surveillance period, starting on day 15 after vaccination.

Short-term dynamic changes in neutralizing antibodies against enterovirus 71 after vaccination.

Background: Short-term dynamic changes in neutralizing antibodies against EV71 and EV71-IgM after inactivated EV71 vaccine injection are unknown.

Methods: This study was designed as a randomized, open-label study and was registered at ClinicalTrials.gov (NCT03278132).

[Surveillance of potential transmission factors of schistosomiasis in Xiuzhou District of Jiaxing City from 2013 to 2015].

Objective: To understand the potential risk of schistosomiasis transmission in Xiuzhou District of Jiaxing City, so as to provide the scientific evidence for consolidating schistosomiasis control achievements.

Methods: Fixed and mobile surveillance sites were set up in Xiuzhou District of Jiaxing City from 2013 to 2015. snails was surveyed historical snail habitats, current snail habitats, and suspected snail habitats.

[Disease burden of influenza in schools and child care settings in rural areas of Hangzhou, 2016-2018].

The objective of this study was to analyze the disease burden of influenza in schools and child care settings in rural areas of Hangzhou. Hospital visit influenza cases aged 3-17 years in hospitals that reported based on influenza surveillance system from 2016 to 2018 in Chun'an county, Hangzhou city were selected as study subjects and a total of 294 confirmed cases of influenza were selected using system sampling method. Questionnaires were designed to investigate the basic information and data on inpatients and outpatients among, health care and life quality, etc.

[Schistosomiasis surveillance after interruption of schistosomiasis transmission in Xiuzhou District, Jiaxing City].

Objective: To analyze the endemic situation of schistosomiasis after its interruption of transmission in Xiuzhou District, Jiaxing City, Zhejiang Province, so as to provide the references for future surveillance work.

Methods: The data of schistosomiasis and snails in Xiuzhou District were collected and analyzed statistically.

Results: From 1994 to 2015, totally 975 village-times were investigated for snails, and the accumulated area of 4 385.

[Causation of Oncomelania snail recurrence in water-net areas of Jiaxing City].

From 2004 to 2012, fourteen Oncomelania snail remaining spots with an area of 31.954 hm2 were found in the historical snail areas of Xiuzhou District, Jiaxing City. The recurrence time of snails was 5-39 years.

Protective effect of inactivated hepatitis A vaccine against the outbreak of hepatitis A in an open rural community.

Aim: To evaluate the protective effect of inactivated hepatitis A vaccine (Healive) against hepatitis A outbreak in an emergency vaccination campaign.

Methods: During an outbreak of hepatitis A in Honghe Town, Xiuzhou District, Jiaxing City, Zhejiang Province, two nonrandomized controlled trials were conducted in September 2006. The first trial was to vaccinate 108 anti-HAV negative individuals with close contacts of the patients from September with 1 dose of an inactivated hepatitis A vaccine, Healive.