Spatially aligned graph transfer learning for characterizing spatial regulatory heterogeneity.

Spatially resolved transcriptomics (SRT) technologies facilitate the exploration of cell fates or states within tissue microenvironments. Despite these advances, the field has not adequately addressed the regulatory heterogeneity influenced by microenvironmental factors. Here, we propose a novel Spatially Aligned Graph Transfer Learning (SpaGTL), pretrained on a large-scale multi-modal SRT data of about 100 million cells/spots to enable inference of context-specific spatial gene regulatory networks across multiple scales in data-limited settings.

Biocompatible autonomous self-healing PVA-CS/TA hydrogels based on hydrogen bonding and electrostatic interaction.

The biocompatible autonomous self-healing hydrogels have great potential in biomedical applications. However, the fairly weak tensile strength of the hydrogels seriously hinders their application. Here, we introduced chitosan (CS) into the polyvinyl alcohol (PVA)-tannic acid (TA) hydrogel and investigated the effects of the CS content, as CS can not only form reversible H bonds with PVA and TA but also form reversible electrostatic interactions with TA.

Research on Quantitative Characterization Model of Compressive Strength or Elastic Modulus of Recycled Concrete Based on Pore Grading.

The influence of different pore sizes on the compressive strength and elastic modulus of recycled concrete is an important issue in the academic circle. Aiming at this problem, a quantitative characterization model of the compressive strength and elastic modulus of recycled concrete based on pore grading was established in this paper. The compressive strength, elastic modulus, porosity and distribution of pore size of recycled concrete were measured by a concrete test and nuclear magnetic resonance technology, and the influences of different pore sizes on the compressive strength and elastic modulus of recycled concrete were analyzed, and the rationality of the quantitative characterization model was verified.

The impact and mechanism of E-commerce of agricultural products on nongrain production of cultivated land in rural China.

Improving China's grain production level is conducive to achieving the sustainable development goal of zero hunger worldwide by 2030. As an important innovation in sales channels, e-commerce of agricultural products (EAP) directly affects grain production. However, no study has directly discussed the impact and mechanism of EAP on nongrain production of cultivated land (NGPL).

The impact of energy structure on agricultural green productivity in China.

The agricultural development in China is currently grappling with the challenges of limited water and soil resources, environmental pollution, and ecosystem degradation. Therefore, improving agricultural green productivity has become the focus of academic attention. Based on the panel data of 30 provinces in China from 2008 to 2020, this paper constructs an index system of agricultural productivity.

Construction and Evaluation of a Predictive Model for Grassroots Nurses' Risk Perception of "Internet + Nursing Services": A Multicenter Cross-Sectional Study.

Purpose: The development of "Internet + nursing services" can effectively solve the problem of population aging, and grassroots nurses are the primary providers of such services in rural areas. This study aimed to analyze the factors affecting grassroots nurses' risk perception of "Internet + nursing services" and construct a predictive model.

Patients And Methods: A multicenter cross-sectional study of 2220 nurses from 27 secondary hospitals and 36 community health centers in Hubei Province was conducted from August to December 2023 using a multi-stage cluster sampling method.

Optical-Propulsion Metastructures.

Pulsed laser micropropulsion (PLMP) offers a promising avenue for miniature space craft, yet conventional propellants face challenges in balancing efficiency and stability. An optical-propulsion metastructure strategy using metal-organic frameworks (MOFs) is presented to generate graphene-metal metastructures (GMM), specifically GMM-(HKUST-1), which significantly enhances PLMP performance. This novel approach leverages the unique interaction between pulsed lasers and the precisely engineered GMMs-comprising optimized metal nanoparticle size, graphene layers, and inter-particle gaps-to boost both propulsion efficiency and stability.

Size-Dependent Oxygen Vacancy of Iron Oxide Nanoparticles.

Prior research has highlighted the reduction of iron oxide nanoparticle (IONPs) sizes to the "ultra-small" dimension as a pivotal approach in developing T-MRI contrast agents, and the enhancement in T contrast performance with the reducing size is usually attributed to the increased specific surface area and weakened magnetization. Nonetheless, as the size decreases, the variation in surface defects, particularly oxygen vacancy (V) defects, significantly impacts the T imaging efficacy. In this study, the V on IONPs is meticulously investigated through XPS, Raman, and EPR spectroscopy.

The impact of regional sports industry aggregation on residents' health level in China.

Health is the basis for human survival and development and is an important symbol to evaluate a country's economic growth and social progress. This article measures the degree of sports industry agglomeration in different regions of China and uses the Moran index to verify the existence of global autocorrelation in sports agglomeration. Next, the spatial Durbin model was used to verify the spatial spillover effect of sports industry agglomeration on the health level of residents, and the following conclusions were obtained.

Antifungal Activity and Mechanism of Camphor Derivatives against : A Promising Alternative Antifungal Agent for Rice Sheath Blight.

Rice sheath blight, caused by the fungus , poses a significant threat to rice cultivation globally. This study aimed to investigate the potential mechanisms of action of camphor derivatives against . Compound exhibited superior fungicidal activities in vitro (EC = 6.

Integrated transcriptome and metabolome analysis reveals the regulation of phlorizin synthesis in Lithocarpus polystachyus under nitrogen fertilization.

Background: Nitrogen (N) is essential for plant growth and development. In Lithocarpus polystachyus Rehd., a species known for its medicinal and food value, phlorizin is the major bioactive compound with pharmacological activity.

Relationship between 24-h activity behavior and body fat percentage in preschool children: based on compositional data and isotemporal substitution analysis.

Objective: This study aims to elucidate the dose‒response relationship between 24-h activity behaviors and body fat percentage (BFP) in Chinese preschool children using a compositional isotemporal substitution model (ISM).

Methods: In a cross-sectional design, 881 children aged 3-6 from urban and rural areas of Jiangxi Province were sampled. Activity behaviors, including sedentary behavior (SB), low-intensity physical activity (LPA), and moderate- to high-intensity physical activity (MVPA), were measured using accelerometers.

Pulchinenoside B4 ameliorates oral ulcers in rats by modulating gut microbiota and metabolites.

Pulchinenoside B4, a natural saponin monomer from the Pulsatilla plant, plays an important role as an immunomodulator in the treatment of acute inflammation. Oral ulcer (OU) is a common ulcerative injury disease that occurs in the oral mucosa, including mucosal ulceration and abnormalities of lips and tongue. A close correlation exists between gut microbiota and circulating metabolites in patients with OU.

The impact of land transfer policy on sustainable agricultural development in China.

At present, China's agricultural development presents problems such as increasingly tight constraints on water and soil resources, increased pollution in the process of agricultural production, and noticeable degradation of agricultural ecosystems. So, it is urgent to promote the sustainable development of agriculture. From the perspective of land transfer policy, based on the panel data of 30 regions in China from 2006 to 2020, this paper uses the entropy weight method to calculate the level of sustainable agricultural development.

Resolution of N-acetyl-DL-methionine methyl ester by the lipase from Brucella thiophenivorans.

In this study, lipase-catalyzed resolution of N-acetyl-DL-methionine methyl ester (N-Ac-DL-MetOMe) was evaluated. A lipase from Brucella thiophenivorans was prone to exhibit high activity and excellent enantioselectivity toward N-Ac-DL-MetOMe to produce the key chiral intermediate N-acetyl-L-methionine methyl ester (N-Ac-L-MetOMe). The results showed that the enzymatic reaction was carried out in 100 g/L racemic substrate for 2 h, the conversion reached 51.

Combined exposure with microplastics increases the toxic effects of PFOS and its alternative F-53B in adult zebrafish.

Microplastics (MPs) can adsorb and desorb organic pollutants, which may alter their biotoxicities. Although the toxicity of perfluorooctane sulfonate (PFOS) and its alternative 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) to organisms has been reported, the comparative study of their combined toxic effects with MPs on aquatic organisms is limited. In this study, adult female zebrafish were exposed to 10 μg/L PFOS/F-53B and 50 μg/L MPs alone or in combination for 14 days to investigate their single and combined toxicities.

Rapid Evaporation of a Metal Electrode for a High-Efficiency Perovskite Solar Cell.

Organic-inorganic hybrid perovskite solar cells (PSCs) have attracted considerable attention due to the excellent optoelectronic properties of perovskite materials. The energy consumption and high cost issues of metal electrode evaporation should be addressed before large-scale manufacturing and application. We developed an effective metal electrode evaporation procedure for the fabrication of high-efficiency planar heterojunction (PHJ) PSCs, with an inverted device structure of glass/indium tin oxide (ITO)/poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine] (PTAA)/perovskite/[6,6]-phenyl-C61-butyric acid methyl ester (PCBM)/(E)-β-caryophyllene (BCP)/Ag.

Etching-induced ion exchange engineering of two-dimensional layered NiFeCo-based hydroxides for high energy charge storage.

Efficient and rapid synthesis of transition metal-based hydroxides with tailored microstructures has emerged as a promising approach to fabricate high-performance electrode materials for energy storage devices. However, many conventional synthesis methods are cumbersome, expensive and time-consuming, and the microstructures of electrode materials are usually uncontrollable. Herein, we propose a fast and cost-effective approach to electrochemically grow NiFeCo-based ternary hydroxides (NiFeCo-THs) with layered nanosheet structures on pretreated nickel foam (NF).

Simulation examining the factors influencing capillary wick transport in a refrigerant direct cooling system for power battery packs.

The effectiveness of power battery refrigerant direct cooling systems of electric vehicles incorporating capillary wicks is directly determined by these wicks' transport performance. The Fries-Dreyer equation describes wicking behavior, but there is a significant gap between its predictions and the experimental results as reported in the literature. This work examines the factors influencing transport performance in an unconsolidated capillary wick with spherical particles.

Preparation and Characterization of Polycarbonate-Based Blend System with Favorable Mechanical Properties and 3D Printing Performance.

Recently, material extrusion (MEX) 3D printing technology has attracted extensive attention. However, some high-performance thermoplastic polymer resins, such as polycarbonate (PC), cannot be processed by conventional MEX printing equipment due to poor processing performance. In order to develop new PC-based printing materials suitable for MEX, PC/poly(butylene adipate-co-terephthalate) (PBAT) blends were prepared using a simple polymer blending technique.

Resilient and Tough Conductive Polymer Hydrogel for a Low-Hysteresis Strain Sensor.

Conductive polymer hydrogels are vital in strain sensors, yet achieving high resilience and toughness is a challenge. This study employs a prestretch method to engineer a tough conductive polymer hydrogel with sufficient resilience. Initially, a blend film of polyvinylalcohol (PVA) and ethylene-vinyl alcohol copolymer (EVOH) is prepared through solution casting, followed by a swelling process to form a PVA-EVOH hydrogel.