Establishment of a programmatic detection method for Trichomonas vaginalis based on double antibody sandwich ELISA targeting TvCP39 antigen.

Background: Trichomonas vaginalis (T. vaginalis) is a common sexually transmitted parasite that colonizes the human urogenital tract. Programmed and precise detection of T.

Abnormal regional brain activity in patients with first-episode medication-naïve depressive disorder: A longitudinal fNIRS study.

The potential relationship between abnormal brain activity and clinical symptoms in patients with major depressive disorder (MDD) is important for auxiliary diagnosis and prediction of the curative effect of treatments for MDD. Before antidepressant treatment (T1), 4 weeks after treatment (T2), and 8 weeks after treatment (T3), 33 patients with first-episode medication-naïve MDD and 30 healthy controls (HCs) were examined using functional near-infrared spectroscopy (fNIRS) to evaluate the cerebral hemodynamic response in the frontal and temporal cortex during the Verbal Fluency Task (VFT). Compared with HCs, VFT scores and activation levels of the frontal pole, inferior frontal gyrus, and dorsolateral prefrontal cortex were significantly decreased in the first-episode medication-naïve depressive disorder patients (FMD).

The bidirectional association between self-perceptions of aging and frailty: the mediating role of subjective cognitive decline.

Objective: With the global population aging rapidly, understanding the factors influencing health outcomes in older adults is crucial. This study explores the longitudinal causal relationship between self-perceptions of aging and frailty and examines whether subjective cognitive decline mediated the associations.

Methods: The Brief-Aging Perceptions Questionnaire(B-APQ), the Frailty Phenotype Assessment Scale, and the Subjective Cognitive Decline Questionnaire were used to survey 619 community-dwelling older adults in Xinxiang, Henan, China, from March to October 2021 and from March to October 2023, respectively.

[Risk assessment of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis and hypertension: a propensity score matching-based retrospective cohort study].

Objective: To analyze the factors affecting the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B-associated cirrhosis (CHB-Cir) complicated by essential hypertension (EH) and explore the impact of EH on HCC risk in patients with CHB-Cir.

Methods: This study was conducted among the patients with CHB-Cir with or without EH received antiviral therapy in the Infectious Disease Department, Third Affiliated Hospital of Xinxiang Medical University from January, 2017 to January, 2024. The cases with insufficient follow-up time or missing data were excluded.

[The relationship between auditory verbal hallucination and gray matter volume and cortical thicknessin first-episode childhood-onset schizophrenia].

To analyze the relationship of gray matter volume and cortical thickness of auditory verbal hallucination in first-episode childhood-onset schizophrenia(COS). Sixty cases of first-episode childhood-onset schizophrenia who were treated in the inpatient department of the Second Affiliated Hospital of Xinxiang Medical University from October 2020 to February 2024 were collected(case group).Thirty-two healthy students from a primary and secondary school in Xinxiang city were the control group.

PPAB001, a novel bispecific antibody against CD47 and CD24, enhances anti-PD-L1 efficacy in triple-negative breast cancer via reprogramming tumor-associated macrophages towards M1 phenotype.

Triple-negative breast cancer (TNBC) is a biologically aggressive tumor with a strong association with a high recurrence rate and poor prognosis. Although anti-PD-L1 antibody, Tecentriq has been approved by FDA for treating TNBC, the overall response rate (ORR) is still generally less than 20 %. PPAB001 is a novel bispecific antibody simultaneously targeting CD47 and CD24.

Randomized, Phase III Trial of Mixed Formulation of Fosrolapitant and Palonosetron (HR20013) in Preventing Cisplatin-Based Highly Emetogenic Chemotherapy-Induced Nausea and Vomiting: PROFIT.

Purpose: Mixed formulation of fosrolapitant and palonosetron (PALO), HR20013, is a novel fixed-dose intravenous antiemetic combination that could simultaneously antagonize neurokinin-1 and 5-hydroxytryptamine-3 receptors. This study was designed to evaluate the efficacy and safety of HR20013 plus dexamethasone (DEX) versus fosaprepitant (FAPR) plus PALO + DEX for preventing chemotherapy-induced nausea and vomiting (CINV) in patients receiving highly emetogenic chemotherapy (HEC).

Methods: This is a noninferiority study.

Case report: Infection-associated HPS during pregnancy cured by HLH-94 protocol with induction therapy of ruxolitinib.

Hemophagocytic syndrome (HPS) is a rapidly progressive and highly fatal disease, and is even more complex when it occurs during pregnancy. Currently, the HLH-94 protocol is commonly used for treatment for HPS, with ruxolitinib being mostly used for salvage therapy. Here, we report a pregnant woman who presented with fever, thrombocytopenia, splenomegaly, and subsequently developed into severe pneumonia and multiple organ dysfunction(MODS).

Dynamic contrast‑enhanced MRI combined with intravoxel incoherent motion in quantitative evaluation for preoperative risk stratification of resectable rectal adenocarcinoma.

Rectal adenocarcinoma is a common malignant tumor of the digestive tract. However, it is difficult to obtain tumor microstructural information using conventional magnetic resonance imaging (MRI). Dynamic contrast-enhanced (DCE)-MRI and intravoxel incoherent motion (IVIM) have been used in tumor research.

Network integration and segregation changes in schizophrenia: impact of electroconvulsive therapy.

Background: Studies have confirmed brain network topology disruption in schizophrenia (SZ). Electroconvulsive therapy (ECT) rapidly improves acute psychiatric symptoms, yet the exact mechanism by which it impacts brain network topology in SZ patients remains unclear. This study aims to explore topological changes in SZ patients' whole-brain functional networks during ECT, ultimately elucidating implicated neurological mechanisms.

Healing action of Interleukin-4 (IL-4) in acute and chronic inflammatory conditions: Mechanisms and therapeutic strategies.

Interleukin-4 (IL-4), which is traditionally associated with inflammation, has emerged as a key player in tissue regeneration. Produced primarily by T-helper 2 (Th2) and other immune cells, IL-4 activates endogenous lymphocytes and promotes M2 macrophage polarization, both of which are crucial for tissue repair. Moreover, IL-4 stimulates the proliferation and differentiation of various cell types, contributing to efficient tissue regeneration, and shows promise for promoting tissue regeneration after injury.

RNF144A inhibits autophagy by targeting BECN1 for degradation during infection.

is widely used in the laboratory as an infection model for the research on pathogenesis and host defense against gram-positive intracellular bacteria. Macroautophagy (called simply "autophagy" hereafter), is important in the host defense against pathogens, such as bacteria, viruses, and parasites. BECN1 plays a pivotal role in the initiation of autophagy and accumulating evidence indicates that post-translational modifications of BECN1 provide multiple strategies for autophagy regulation.

[Impact of ambient air pollution on hospital visits for mental and behavioral disorders among residents in an industrial area in Henan Province from 2016 to 2021].

To explore the impact of air pollution on hospital visits for mental and behavioral disorders among residents in an industrial area in Henan Province from 2016 to 2021. Daily outpatient visits data for mental and behavioral disorders were collected from Angang General Hospital in Angang Industrial Area at Anyang City between January 2016 and December 2021. And air pollutants and meteorological data during the same period were also collected.

Pd(II)-catalyzed regioselective ring opening/[3+2] annulation reaction of enaminones with cyclopropenones: divergent synthesis of γ-butenolides and γ-lactams.

A practical, effective, and regioselective palladium-catalyzed ring opening/[4+2] annulation of enaminones with cyclopropenones for the controllable synthesis of highly substituted γ-butenolides and γ-lactams has been described. This method for the first time reports the regio-selective annulation reaction on the carbon and amine groups of the enaminone structure. This reaction is characterized by its wide substrate scope, good functional group compatibility, moderate to good yields, scale-up synthesis, and versatile transformations, providing a versatile and general protocol to construct γ-butenolides and γ-lactams.

Reprogramming of Expanded Cord Blood-Derived CD34 Cells from Umbilical Cord-Mesenchymal Stromal Cell Co-Culture to Generate Human-Induced Pluripotent Stem Cells.

Cord blood (CB) is widely stored as a source of hematopoietic stem cells for potential future use, though its application for autologous purposes remains limited. Repurposing CB into human-induced pluripotent stem cells (hiPSCs) can broaden its utility beyond hematological conditions. This study investigated the effects of umbilical cord-mesenchymal stromal cell (UC-MSC) co-culture on CB CD34 cells and the characteristics of the resulting hiPSCs.

Correction: Wu et al. Synthesis of Spirooxindole--Naphthoquinone-Tetrazolo[1,5-]Pyrimidine Hybrids as Potential Anticancer Agents. 2018, , 2330.

In the original publication [...

Perilla Seed Oil: A Review of Health Effects, Encapsulation Strategies and Applications in Food.

Perilla ( L.) is an annual herbaceous plant whose seed oil is rich in unsaturated fatty acids such as alpha-linolenic acid (ALA). This oil exhibits various health benefits, including antioxidant, anti-inflammatory, lipid-lowering, hypoglycemic, neuroprotective and immunomodulatory activities.

In Situ and Label-Free Quantification of Membrane Protein-Ligand Interactions Using Optical Imaging Techniques: A Review.

Membrane proteins are crucial for various cellular processes and are key targets in pharmacological research. Their interactions with ligands are essential for elucidating cellular mechanisms and advancing drug development. To study these interactions without altering their functional properties in native environments, several advanced optical imaging methods have been developed for in situ and label-free quantification.

Dielectric Surface-Based Biosensors for Enhanced Detection of Biomolecular Interactions: Advances and Applications.

Surface plasmon resonance (SPR) biosensors are extensively utilized for analyzing molecular interactions due to their high sensitivity and label-free detection capabilities. Recent innovations in surface-sensitive biosensors with dielectric surfaces address the inherent limitations associated with traditional gold surfaces, such as thermal effects and biocompatibility issues, which can impede broader applications. This review examines state-of-the-art biosensor configurations, including total internal reflection, optical waveguide, photonic crystal resonators, Bloch surface wave biosensors, and surface electrochemical biosensors, which can enhance analyte signals and augment the molecular detection efficiency at the sensor interface.