IDO1-mediated M2 macrophage polarization alleviates the progression of ankylosing spondylitis.

Indoleamine 2,3-dioxygenase 1 (IDO1) plays an anti-inflammatory role in autoimmune disease. However, its specific function in ankylosing spondylitis (AS) remain unclear. This study aimed to investigate the potential role of IDO1 in AS.

Metabolomic analysis reveals an important role of sphingosine 1-phosphate in the development of HFMD due to EV-A71 infection.

Hand, foot, and mouth disease (HFMD) is a serious pediatric infectious disease that causes immeasurable physical and mental health burdens. Currently, there is a lack of information on the mechanisms of HFMD severity and early diagnosis. We performed metabolomic profiling of sera from 84 Enterovirus A71 (EV-A71) infections and 45 control individuals.

Research progress on treatment measures for joint function in non-surgical patients with knee osteoarthritis.

As human lifespan increases and the proportion of obese people increases, the prevalence of knee osteoarthritis continues to increase. Its main clinical manifestations include joint pain, snapping, and decreased joint function. Due to the slow progression of the disease in KOA, patients have been troubled by the disease for a long time, affecting their quality of life.

Associations of posttraumatic stress disorder symptoms with amyloid burden in cognitively normal older adults.

Background: Posttraumatic stress disorder (PTSD) is associated with the development of dementia. However, the link between PTSD and preclinical Alzheimer's disease pathology (amyloid [Aβ]) remains controversial. Moreover, the correlation between the severity of PTSD with Aβ levels remains unknown.

Neuregulin 1 improved gastric motility and reduced gastric inflammation by activating the α7nAChR through the cholinergic anti-inflammatory pathway in diabetic rats.

Diabetic gastroparesis (DGP), a prevalent complication of diabetes, is characterized by delayed gastric emptying and inflammation. The dorsal motor nucleus of the vagus (DMV) plays a crucial role in modulating gastric function via the vagus nerve. Neuregulin 1 (NRG1), which is present in the DMV and influences the autonomic nervous system, has an unclear role in DGP.

Corrigendum: Exogenous let-7a-5p induces A549 lung cancer cell death through BCL2L1-mediated PI3Kγ signaling pathway.

[This corrects the article DOI: 10.3389/fonc.2019.

Honokiol ameliorates silica-induced lung fibrosis by inhibiting macrophage pyroptosis via modulating cGAS/STING signaling.

Silicosis is a life-threatening occupational disease because of inhaling silica dust, leading to chronic inflammation, pyroptosis, and fibrosis. Unfortunately, it is still lacking effective pharmacological intervention currently. Honokiol (HKL), a natural extract with biological activity from Magnolia bark, is known for its antioxidant and anti-inflammatory biological effects.

A Novel Peroxisome-Related Gene Signature Predicts Breast Cancer Prognosis and Correlates with T Cell Suppression.

Background: Peroxisomes are increasingly linked to cancer development, yet the prognostic role of peroxisome-related genes (PRGs) in breast cancer remains unclear.

Objective: This study aimed to construct a prognostic model based on PRG expression in breast cancer to clarify their prognostic value and clinical implications.

Methods: Transcriptomic data from TCGA and GEO were used for training and validation cohorts.

Association between alcohol consumption levels and pelvic inflammatory disease: Findings from the NHANES 2013-2020.

Background And Aim: Pelvic inflammatory disease (PID) is a common and serious infection affecting women's reproductive health, which may result in severe consequences, such as infertility. This research is to investigate the association between alcohol consumption levels and the odds of PID prevalence, providing insights that could inform public health policies.

Methods And Results: The U.

Epigenetic activation of JAG1 by AID contributes to metastasis of hepatocellular carcinoma.

Metastasis is a major cause of fatality in hepatocellular carcinoma (HCC), although the precise mechanisms driving the metastatic process remain incompletely understood. In this study, we have made several important findings. Firstly, we have discovered that elevated activation-induced cytidine deaminase (AID) expression is positively correlated with Jagged 1 (JAG1) levels in clinically metastatic HCC patients.

Association of blood cadmium and physical activity with mortality: A prospective cohort study.

Physical activity (PA) may be considered an alternative method to ameliorate the elevated mortality risks associated with cadmium exposure. In this prospective cohort study, a total of 20,253 participants (weighted mean age, 47.79 years), including 10,247 men (weighted prevalence: 50.

Coumarin-based fluorescent probes for the detection of copper (II) and imaging in mice of Wilson's disease.

Copper is an essential redox-active metal nutrient, with tightly regulated homeostasis. Copper homeostasis is closely linked to various diseases, making it a critical area of study. Fluorescent probes serve as powerful tools for investigating these conditions.

The entorhinal cortex and cognitive impairment in schizophrenia: A comprehensive review.

Schizophrenia, a severe mental illness characterized by cognitive impairment and olfactory dysfunction, remains an enigma with its pathological mechanism yet to be fully elucidated. The entorhinal cortex, a pivotal structure involved in numerous neural loop circuits related to olfaction, cognition, and emotion, has garnered significant attention due to its structural and functional abnormalities, which have been implicated in the pathogenesis of schizophrenia. This review focuses on the abnormal structural and functional changes in the entorhinal cortex in schizophrenia patients, as evidenced by neuroimaging, cellular biology, and genetic studies.

miR-375-3p predicts the severity of endometriosis and regulates cellular progression by targeting NOX4.

Background: Due to the complex pathogenesis of endometriosis, its early screening and development prediction are still challenging problems in the clinic.

Objectives: This study evaluated the significance of miR-375-3p in endometriosis onset, progression, and recurrence, aiming to identify a novel biomarker for disease diagnosis and prognosis.

Materials And Methods: The study enrolled 100 patients with endometriosis and 80 healthy females.

Nerol attenuates doxorubicin-induced heart failure by inhibiting cardiomyocyte apoptosis in rats.

Background: As a broad-spectrum anti-tumour drug, the clinical application of DOX is often limited owing to its cardiotoxicity. Nerol is a naturally occurring compound with both anti-inflammatory and antioxidant properties. However, the ability of Nerol to improve DOX-induced heart failure and its underlying mechanisms remain unclear.

Mitochondrial transplantation rescues Ca homeostasis imbalance and myocardial hypertrophy in SLC25A3-related hypertrophic cardiomyopathy.

SLC25A3 encodes mitochondrial phosphate carrier (PiC), which is involved in inorganic phosphate transport. Clinical reports have found that most patients with homozygous or complex heterozygous mutations in SLC25A3 exhibit lactic acidosis, cardiac hypertrophy, and premature death. However, the potential molecular mechanisms underlying these associations remain unclear.

Pavlovian theory and the development of traditional Chinese medicine, 1949-1961.

After the founding of the People's Republic of China in 1949, the leadership of the new country carried out a political, cultural, and scientific campaign to "comprehensively learn from the Soviet Union," with the goal of rapid development on all fronts. In the realm of medicine, this had profound consequences. The hegemonic Soviet theory of physiology and psychology-Pavlovianism-became highly influential in China, first as Party Line and second as the basis for a reformed "traditional Chinese medicine".

Optimizing acute chest pain diagnosis: Efficacy of 64-channel multi-slice CT with Snap-Shot Freeze technique in Triple-Rule-out CT angiography.

Objective: This study evaluates the efficacy of Snap-Shot Freeze (SSF) technology combined with optimized contrast medium (CM) injection protocols in Triple-Rule-Out (TRO) computed tomography angiography (CTA) using 64-channel multi-slice CT (MSCT) for diagnosing acute chest pain (ACP).

Materials And Methods: A total of 111 patients presenting with ACP were enrolled and divided into two groups: Group 1 (23 patients) underwent TRO CTA using 64-channel MSCT with SSF technology, while the control group (88 patients) which was further divided into three cohorts underwent specific site CTA scans. Quantitative metrics such as CT values, standard deviation (SD), signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) were calculated for pulmonary artery, coronary arteries, and aortic imaging.

STT3-mediated aberrant N-glycosylation of CD24 inhibits paclitaxel sensitivity in triple-negative breast cancer.

Paclitaxel is one of the main chemotherapic medicines against triple-negative breast cancer (TNBC) in clinic. However, it has been perplexed by paclitaxel resistance in TNBC patients, resulting in a poor prognosis. Abnormal protein glycosylation is closely related to the occurrence and progression of tumors and malignant phenotypes such as chemotherapy resistance.

NH-MIL-125(Ti)/TiO heterojunction with non-disturbed dual reactive centers for synchronous photocatalytic removal of Cr(VI) and organic dyes.

Chromium (VI) (Cr(VI)) generally coexists with organic dyes in industrial effluents, posing a formidable challenge in water purification. Herein, NH-MIL-125(Ti)/TiO Z-scheme heterojunction with intimate interfacial contact was synthesized for synchronous removal of pollutant in coexisting Cr(VI)/dyes system under simulated solar irradiation. Structural and optical investigations indicated that a well-defined interface was formed by establishing a Ti-N-C bond, facilitating the spatial separation of the photoexcited carriers of the Z-scheme heterojunction.

Palladium-Catalyzed Autotandem Ring-Opening of Cyclopropanols with Gem-Dibromoolefins for the Synthesis of β-Pyrrolo[1,2-]quinolinyl Ketones.

Herein, the palladium-catalyzed autotandem reaction of cyclopropyl alcohols with gem-dibromoolefins is described. This reaction system involves two distinct mechanistic processes, both efficiently catalyzed by the same palladium catalyst. This approach accommodates a wide substrate scope using readily available starting materials, offering a new and efficient method for synthesizing a series of β-pyrrolo[1,2-]quinolinyl ketones.

S100A4 targets PPP1CA/IL-17 to inhibit the senescence of sheep endometrial epithelial cells.

Background: Gonadotropin-releasing hormone (GnRH) is commonly used in animal reproduction and production, but it was previously reported that GnRH decreases the embryo implantation rate during artificial insemination or embryo transfer in sheep. In addition to the finding that GnRH can target S100A4 to inhibit endometrial epithelial cells proliferation, it was also found that endometrial cells were in poor condition and experienced cell death in S100A4 knockout mice, but the mechanism is unclear.

Methods: The protein PPP1CA, which interacts with S100A4, was detected by immunoprecipitation-mass spectrometry of overexpression and knockdown of S100A4 and PPP1CA.

A novel annexin dimer targets microglial phagocytosis of astrocytes to protect the brain-blood barrier after cerebral ischemia.

Despite the vital role of astrocytes in preserving blood-brain barrier (BBB) integrity, their therapeutic potential as targets in ischemic stroke-induced barrier disruption remains underexplored. We previously reported externalization of phosphatidylserine (PS) on astrocytic membranes concurrent with the emergence of PS externalization in neurons. PS externalization of astrocytes induced microglial phagocytosis of astrocytes, resulting in reduced astrocyte-vascular coupling and subsequent BBB breakdown.

PEG-modification enhances the targeted photothermal therapy of affibody-conjugated indocyanine green for precision cancer treatment.

Photothermal therapy (PTT) is an innovative cancer treatment that leverages heat generated from near-infrared light exposure to induce tumor cell death. A major challenge in PTT is achieving precise delivery of the photothermal agent to tumor tissues to maximize efficacy and minimize off-target effects. In this study, we introduce a novel ligand-coupled photothermal reagent that addresses this challenge by leveraging the high-affinity HER2 affibody Z (referred to as Z), conjugated with indocyanine green (ICG) for targeted delivery.