The Anti-Vitiligo Effects of Feshurin In Vitro from and the Mechanism of Action.

Background: Vitiligo is a complex disorder characterized by skin depigmentation; the canonical Wnt signaling pathway that involves -catenin plays a crucial role in promoting the melanin production in melanocytes. Targeted inhibition of the Janus kinase JAK-STAT pathway can effectively diminish the secretion of the chemokine C-X-C motif ligand CXCL10, thereby safeguarding melanocytes. has been applied as a treatment regimen for a long period; however, its use for the treatment of vitiligo has not been previously documented.

Microscopic Processing of Transparent Material with Nanosecond and Ultrafast Lasers.

Due to their excellent light transmission, heat resistance, corrosion resistance, high mechanical strength, and other characteristics, transparent materials have been widely used in emerging industries such as aviation, aerospace, microelectronics, interconnected communication, etc. Compared with the traditional mechanical processing and chemical processing of transparent materials, laser processing, with such characteristics as a high peak power, high energy density, and non-contact processing, has a lot of obvious advantages in processing efficiency and accuracy. In this paper, some of the recent research advancements concerning the laser processing of transparent materials are introduced in detail.

Numerical analysis of fiber reinforced composite material for structural component application.

Nowadays, convectional metallic material replaced by composite materials, because composite materials have superior than metallic materials properties such as light weights, higher strength-to-weight ratio, high tensile strength, Low cost, greater design flexibility, better fatigue resistance, renewability, and biodegradability. These properties of composite material are the most basic & common attractive features that make them useful for industrial applications. The main objective of this work is to contribute for a better understanding of the static behavior of structure made from fiber reinforced composite materials, specifically for the case of plate structures.

Modification of natural compounds through biotransformation process by microorganisms and their pharmacological properties.

The biotransformation of natural compounds by fungal microorganisms is a complex biochemical process. Tandem whole-cell biotransformation offers a promising, alternative, and cost-effective method for modifying of bioactive novel compounds. This approach is particularly beneficial for structurally complex natural products that are difficult to be synthesized through traditional synthetic methods.

Sesquiterpenes from the seeds of Cichorium glandulosum and their anti- neuroinflammation activities.

Three previously undescribed sesquiterpenes, along with three known ones were isolated from the seeds of Cichorium glandulosum. The structures of them were elucidated by the analysis of spectroscopic data. The isolated compounds were tested for their neuroprotective effects against LPS-induced neuroinflammation in BV-2 cells.

Emulating "Curvature-Enhanced Adsorbate Coverage" for Superconformal and Orientated Zn Electrodeposition in Zinc-ion-Batteries.

Uneven Zn deposition and unfavorable side reactions have prevented the reversibility of the Zn anode. Herein, we design a rearranged (002) textured Zn anode inspired by a traditional curvature-enhanced adsorbate coverage (CEAC) process to realize the highly reversible Zn anode. The rearranged (002) textured structure directs superconformal Zn deposition by controlling the spatial deposition rate of the rearranged crystal planes, thereby promoting bottom-up "superfilling" of the 3D Zn skeletons.

Isolation of Novel Compounds from Lepidium sativum Seeds and Evaluation of Their Potential Anti-Tumor Activity.

Four undescribed compounds including a pair of enantiomers of a dihydroarylnaphthalene lignan [(±)-1], an arylnaphthalene lignan (2), and an indoleacetic acid ester (3), together with four known compounds (4-7), were isolated from the seeds of Lepidium sativum. Their structures were identified by HRMS and NMR spectroscopic data, and the absolute configuration of these compounds were assigned by ECD data in combination with quantum chemical calculations. Compound (-)-1 had weak inhibitory activity against HeLa cell line with an IC value of 60.

Antimicrobial properties of essential oil extracted from Schizonepeta annua against methicillin-resistant Staphylococcus aureus via membrane disruption.

Schizonepeta annua (Pall.) Schischk. has long been traditionally employed in China for its anti-inflammatory, antimicrobial, and soothing properties.

Exploiting Deep-Ultraviolet Nonlinear Optical Material RbScBOF Originated from Congruously Oriented [BO] Groups.

The exploration and research for deep-ultraviolet (UV) nonlinear optical (NLO) crystals are of great significance for all-solid-state lasers. This work is based on the excellent structural [BO] units which manipulate the excellent performances of famous commercial NLO crystal β-BaBO (β-BBO) to explore new alternatives of deep-UV NLO materials. A deep-UV rare-earth metal borate fluoride RbScBOF (RSBF) is successfully designed by combining the heterovalent ions substitution strategy, and fluorination strategy.

Kinetic Pathway of Diborane Decomposition on Transition Metal Surfaces in Borophene Chemical Vapor Deposition Growth.

The chemical vapor deposition (CVD) method holds promise for the scalable and controlled synthesis of high-quality borophene. However, the current lack of an atomistic understanding of intricate kinetic pathways from precursors to borophene impedes process optimization. Here, we employ first-principles simulations to systematically explore the pyrolytic decomposition pathways of the most used precursor diborane (BH) to borophene on various transition metal surfaces.

Polyphenol-Rich Extract of L. Leaves Protects Human Retinal Pigment Epithelial Cells against High Glucose-Induced Damage through Polyol Pathway and Autophagy.

Diabetic retinopathy (DR) is a specific microvascular problem of diabetes, which is mainly caused by hyperglycemia and may lead to rapid vision loss. Dietary polyphenols have been reported to decrease the risk of DR. L.

Anti-tumor effects of nanosecond pulsed electric fields in a murine model of pancreatic cancer.

Nanosecond Pulsed Electric Fields (nsPEFs) treatment has demonstrated anti-tumor effects on various cancer cell lines. However, the use of this treatment in pancreatic cancer is limited. This study demonstrated that nsPEFs treatment effectively suppressed the proliferation and metastasis of pancreatic cancer cells, while also inducing DNA damage.

Controlling the quality of Patinopecten yessoensis from the perspective of the ultrasound and ferulic acid influences.

In this study, the effects of ultrasound combined with ferulic acid (FA) on the quality of the Yesso scallop (Patinopecten yessoensis) adductor muscles (SAM) during refrigerated storage were investigated. The results demonstrated that the combined treatment with 350 W ultrasound and FA (UFA) significantly delayed enzyme activities and microbial growth in SAM tissues compared to FA treatment alone. After 6 days of cold storage, samples treated with UFA exhibited higher hardness (2850 g), lower thiobarbituric acid reactive substances (TBARS = 9.

Use of optical absorption and scattering properties to monitor the change of chemical characteristics, particle structure and viscoelasticity during apple puree processing.

This work explored the optical absorption (μ) and reduced scattering (μ') properties at 400-1050 nm (Vis-NIR) and 900-1650 nm (SWIR) of apple puree at different heating times to evaluate their changes in composition and structure. The optical absorption and scattering coefficients of μ and μ' decreased with increasing heating time. The specific μ' coefficients at 432 nm, 455 nm, 1183 nm and 1304 nm were related to particle structural changes.

Eco-friendly and highly efficient PM air filter made from nonwoven basalt fiber and electrospun nanocellulose fiber.

This study addresses the need for high-performance and sustainable air filters by developing a bio-based, high-efficiency particulate air (HEPA) filter. Current HEPA filters often rely on non-biodegradable materials, creating environmental burdens. In this paper, we presented a HEPA filter fabricated from natural basalt fiber (BF) and nanocellulose fiber.

LiNaCaBOFCl and LiNaBO: A Case of Cation-Induced Birefringence Enhancement via Dimensional Changes of Highly Polymerized [BO] Motifs.

Borates, due to their structural chemistry diversity and exceptional performance, are premier material systems for investigating UV optical crystals. The B-O anionic groups with high polymerization (B ≥ 6) are much less in the borate-based system, which is worthy of further research. Herein, cations with different radii and proportions are introduced to borate system, and two new highly polymerized borates, LiNaCaBOFCl (LNCBFC) and LiNaBO (LNBO) were designed and synthesized successfully.

Sulfate Derivatives with Heteroleptic Tetrahedra: New Deep-Ultraviolet Birefringent Materials in which Weak Interactions Modulate Functional Module Ordering.

Deep-ultraviolet (UV) birefringent materials are urgently needed to facilitate light polarization in deep-UV lithography. Maximizing anisotropy by regulating the alignment of functional modules is essential for improving the linear optical performance of birefringent materials. In this work, we proposed a strategy to design deep-UV birefringent materials that achieve functional module ordering via weak interactions.

Production of Martian fiber by in-situ resource utilization strategy.

Many countries and commercial organizations have shown great interest in constructing a Martian base. resource utilization (ISRU) provides a cost-effective way to achieve this ambitious goal. In this article, we proposed to use Martian soil simulant to produce a fiber to satisfy material requirement for the construction of Martian base.

scPriorGraph: constructing biosemantic cell-cell graphs with prior gene set selection for cell type identification from scRNA-seq data.

Cell type identification is an indispensable analytical step in single-cell data analyses. To address the high noise stemming from gene expression data, existing computational methods often overlook the biologically meaningful relationships between genes, opting to reduce all genes to a unified data space. We assume that such relationships can aid in characterizing cell type features and improving cell type recognition accuracy.