863 results match your criteria: "Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine[Affiliation]"

Background And Aims: Many studies of gastric gastrointestinal stromal tumors (g-GISTs) following endoscopic resection (ER) have typically focused on tumor size, with most tumors at low risk of aggressiveness after risk stratification. There have been few systematic studies on the oncologic outcomes of intermediate- or high-risk g-GISTs after ER.

Methods: From January 2014 to January 2020, we retrospectively collected patients considered at intermediate- or high-risk of g-GISTs according to the modified NIH consensus classification system.

View Article and Find Full Text PDF

Chronic inflammatory and immune responses play key roles in the development and progression of chronic obstructive pulmonary disease (COPD). PANoptosis, as a unique inflammatory cell death modality, is involved in the pathogenesis of many inflammatory diseases. We aim to identify critical PANoptosis-related biomarkers and explore their potential effects on respiratory tract diseases and immune infiltration landscapes in COPD.

View Article and Find Full Text PDF

Identification of ferroptosis-related key genes associated with immune infiltration in sepsis by bioinformatics analysis and in vivo validation.

Gene

August 2024

School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China. Electronic address:

Objectives: Sepsis is a life-threatening infectious disease in which an immune inflammatory response is triggered. The potential effect of ferroptosis-related genes (FRGs) in inflammation of sepsis remained unclear. We focused on identifying and validating core FRGs and their association with immune infiltration in blood from currently all patients with sepsis.

View Article and Find Full Text PDF

Background And Objective: The dynamic assessment of disease activity during the follow-up of patients with Crohn's disease (CD) remains a significant challenge. In this study, we aimed to identify the role of dynamic contrast-enhanced ultrasound (DCE-US) in the evaluation of activity of CD.

Methods: In the retrospective study, patients diagnosed with CD in our hospital were included.

View Article and Find Full Text PDF

Regulatory T cells (Tregs) are activated and expanded after exposure to fetal-specific (paternal) antigens. A proportion of Tregs differentiate into memory Tregs (mTregs), exhibiting immune memory function and exerting more potent immunosuppression than naive Tregs (nTregs). However, it is unclear how mTregs are regulated during normal and pathological pregnancies (e.

View Article and Find Full Text PDF

Objective: To evaluate the value of dynamic contrast-enhanced ultrasound (DCE-US) analysis in early prediction of tumor response to systemic treatment in patients with intrahepatic cholangiocarcinoma (ICC).

Patients & Methods: In this retrospective study, patients diagnosed with ICC by core needle biopsy and histopathological results were included. All patients were diagnosed as advanced stages (stage III/IV) by the 8th edition of the American Joint Committee on Cancer (AJCC)/International Union Against Cancer (UICC) TNM staging system.

View Article and Find Full Text PDF

Purpose: To present the outcomes of a new technique for intrascleral fixation of a flanged three-piece foldable intraocular lens (IOL) without a conjunctival incision.

Materials And Methods: We retrospectively reviewed a consecutive series of 12 eyes of 12 patients who underwent scleral IOL fixation using this technique.

Results: The follow-up period ranged 3-12 months.

View Article and Find Full Text PDF

Single-cell RNA sequencing unveils an Odc1-marked endothelial subpopulation critical for pathological angiogenesis.

Clin Transl Med

March 2024

Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China.

View Article and Find Full Text PDF

Retraction of 'Strontium-doped gelatin scaffolds promote M2 macrophage switch and angiogenesis through modulating the polarization of neutrophils' by Tao Li , , 2021, , 2931-2946, https://doi.org/10.1039/D0BM02126A.

View Article and Find Full Text PDF

Importance: Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently the most common chronic liver disease worldwide. It is important to develop noninvasive tests to assess the disease severity and prognosis.

Objective: To study the prognostic implications of baseline levels and dynamic changes of the vibration-controlled transient elastography (VCTE)-based scores developed for the diagnosis of advanced fibrosis (Agile 3+) and cirrhosis (Agile 4) in patients with MASLD.

View Article and Find Full Text PDF

Multiparametric US for Identifying Metabolic Dysfunction-associated Steatohepatitis: A Prospective Multicenter Study.

Radiology

March 2024

From the Department of Interventional Ultrasound, Fifth Medical Center, Chinese PLA General Hospital, No. 28 Fuxing Rd, Beijing 100853, China (F.L., M.B., Z.C., Z.H., J.Y., P.L.); Department of Ultrasound, Tianjin Third Central Hospital, Tianjin, China (X.J., H.Z.); Department of Ultrasound, Huashan Hospital, Fudan University, Shanghai, China (H.D.); Department of Medical Ultrasound, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China (J.Z., R.Z.); Department of Ultrasound in Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China (Y.C.); Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China (W.W.); Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China (X.X.); Department of Ultrasound, General Hospital of Ningxia Medical University, Yinchuan, China (C.M.); Department of Ultrasound Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (M.C.); Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, China (W.C.); Department of Ultrasound, North China University of Science and Technology Affiliated Hospital, Tangshan, China (S.Z.); Department of Pathology, First Medical Center, Chinese PLA General Hospital, Beijing, China (Z.W.); and Department of Ultrasound, The Second Affiliated Hospital of Nanchang University, Nanchang, China (C.Z.).

Background Noninvasive evaluation of metabolic dysfunction-associated fatty liver disease (MAFLD) with multiparametric US is essential, but multicenter studies are lacking. Purpose To evaluate the ability of multiparametric US with attenuation imaging (ATI) and two-dimensional (2D) shear-wave elastography (SWE) for predicting metabolic dysfunction-associated steatohepatitis (MASH) in participants with MAFLD, regardless of hepatitis B virus infection status. Materials and Methods This prospective cross-sectional multicenter study of consecutive adults with MAFLD who underwent multiparametric US with ATI and 2D SWE, as well as liver biopsy, from September 2020 to June 2022 was conducted in 12 tertiary hospitals in China.

View Article and Find Full Text PDF

Small nucleolar RNA host gene 18 controls vascular smooth muscle cell contractile phenotype and neointimal hyperplasia.

Cardiovasc Res

May 2024

William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.

Aims: Long non-coding RNA (LncRNA) small nucleolar RNA host gene 18 (SNHG18) has been widely implicated in cancers. However, little is known about its functional involvement in vascular diseases. Herein, we attempted to explore a role for SNHG18 in modulating vascular smooth muscle cell (VSMC) contractile phenotype and injury-induced neointima formation.

View Article and Find Full Text PDF

Predicting long-term outcomes for acute ischemic stroke using multi-model MRI radiomics and clinical variables.

Front Med (Lausanne)

March 2024

Department of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Purpose: The objective of this study was to create and validate a novel prediction model that incorporated both multi-modal radiomics features and multi-clinical features, with the aim of accurately identifying acute ischemic stroke (AIS) patients who faced a higher risk of poor outcomes.

Methods: A cohort of 461 patients diagnosed with AIS from four centers was divided into a training cohort and a validation cohort. Radiomics features were extracted and selected from diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) images to create a radiomic signature.

View Article and Find Full Text PDF

Student ultrasound education - current views and controversies.

Ultraschall Med

August 2024

CZMH Medical Physics and Dosimetry Services LTD, Limassol, Cyprus.

As an extension of the clinical examination and as a diagnostic and problem-solving tool, ultrasound has become an established technique for clinicians. A prerequisite for high-quality clinical ultrasound practice is adequate student ultrasound training. In light of the considerable heterogeneity of ultrasound curricula in medical studies worldwide, this review presents basic principles of modern medical student ultrasound education and advocates for the establishment of an ultrasound core curriculum embedded both horizontally and vertically in medical studies.

View Article and Find Full Text PDF
Article Synopsis
  • A 3D brain organoid model is created to investigate POLG-related encephalopathy, a mitochondrial disease caused by POLG mutations, using patient-derived induced pluripotent stem cells (iPSCs).
  • The generated cortical organoids display key disease features like abnormal structure, neuron loss, and depleted mitochondrial DNA, along with changes in critical neuronal development pathways and increased NOTCH and JAK-STAT signaling.
  • Metformin treatment improved several issues found in the organoids, but did not resolve problems with inhibitory dopamine-glutamate neurons, making this model a useful tool for studying POLG disorders and related diseases linked to mitochondrial dysfunction.
View Article and Find Full Text PDF

A novel intracoronary hypothermia device reduces myocardial reperfusion injury in pigs.

Chin Med J (Engl)

October 2024

Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Article Synopsis
  • - The study investigated a new selective intracoronary hypothermia (SICH) device aimed at reducing heart damage caused by reperfusion injury after a myocardial infarction, demonstrating its feasibility, safety, and efficacy.
  • - In a controlled experiment with pigs, the SICH method led to notable reductions in inflammatory markers and improved heart function, evidenced by smaller infarct sizes and better ejection fractions after the treatment compared to the control group.
  • - Throughout the study, the SICH device was well-tolerated, showing no adverse effects on blood pressure or heart rate, and it effectively mitigated heart damage by addressing post-MI inflammatory responses and microvascular issues.
View Article and Find Full Text PDF

Intrahepatic cholangiocarcinoma (ICC) is a type of primary liver cancer, which has shown an increasing trend in incidence and mortality in recent years, with a poor prognosis. The clinical diagnosis and treatment of ICC currently face the challenges of low detection rate, high mortality rate, poor treatment outcome, and urgently need more in-depth research to promote the improvement of clinical diagnosis and treatment level. In recent years, ICC diagnosis and treatment related research has made new progress in many aspects, and the knowledge about these new clinical diagnosis and treatment advances should be updated in a timely manner.

View Article and Find Full Text PDF

Aims: To assess the excess risk of cardiovascular disease (CVD) associated with different criteria for metabolic health, and the interplay of body size, insulin sensitivity and metabolic health with CVD risk.

Materials And Methods: We conducted a prospective study involving 115 638 participants from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. Metabolic health was defined using three different definitions: (1) insulin sensitivity defined by homeostatic model assessment of insulin resistance index; (2) absence of metabolic syndrome according to the National Cholesterol Education Program Adult Treatment Panel III criteria; and (3) simultaneous absence of metabolic abnormalities (diabetes, hypertension, dyslipidaemia).

View Article and Find Full Text PDF

We will discuss a recent case of unexplained neonatal cyanosis, evaluate its origin, clinical presentation, diagnosis, and treatment, and share with you some of our clinical insights. We report a transient cyanosis in a newborn due to a mutation in the globulin gene (HBG2), as well as diagnosis and treatment. Clinically, the infant was in good overall health, and despite low oxygen saturation, the arterial oxygen partial pressure was always normal.

View Article and Find Full Text PDF

B-mode ultrasound to elastography synthesis using multiscale learning.

Ultrasonics

March 2024

Center for Biomedical Engineering, School of Information Science and Technology, Fudan University, Shanghai 200433, China. Electronic address:

Elastography is a promising diagnostic tool that measures the hardness of tissues, and it has been used in clinics for detecting lesion progress, such as benign and malignant tumors. However, due to the high cost of examination and limited availability of elastic ultrasound devices, elastography is not widely used in primary medical facilities in rural areas. To address this issue, a deep learning approach called the multiscale elastic image synthesis network (MEIS-Net) was proposed, which utilized the multiscale learning to synthesize elastic images from ultrasound data instead of traditional ultrasound elastography in virtue of elastic deformation.

View Article and Find Full Text PDF

Normal value of virtual touch imaging quantification elastography in measurements of pancreas.

Clin Hemorheol Microcirc

August 2024

Department Allgemeine Innere Medizin, Kliniken Hirslanden Beau Site, Salem und Permanence, Bern, Switzerland.

Objective: To evaluate pancreatic tissue stiffness and provide a normal reference shear wave velocity (SWV) value of pancreas from healthy adults by Virtual Touch Imaging Quantification (VTIQ) measurements.

Methods: Healthy adult volunteers without known history of hepatobiliary or pancreatic diseases were included. VTIQ elastography (Siemens ACUSON Sequoia, 5C-1 transducer) was used.

View Article and Find Full Text PDF

Introduction: Enthesitis-related arthritis (ERA) is a category of juvenile idiopathic arthritis (JIA). The complications of JIA include pain, muscle weakness, limited movement and worsening quality of life. Yoga is an effective exercise therapy for rheumatoid arthritis and may have similar benefits for JIA.

View Article and Find Full Text PDF

The pathogenesis of dyschromatosis symmetrica hereditaria (DSH) has not been well defined. In this study, we sought to investigate the influence of the ADAR1 gene on DSH both in vitro and in vivo. Morpholino knockdown of adar1 in zebrafish produced phenotypes characterized by polarity changes, and abnormal migration and distribution of melanocytes.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: