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Progress in GABAA receptor agonists for insomnia disorder.
Front Pharmacol
November 2024
Department of Clinical Pharmacy, Xinhua Hospital Affiliated to Shanghai Jiaotong University Affiliated to School of Medicine, Shanghai, China.
Insomnia is the most common sleep disorder in which an individual has trouble falling or staying asleep. Chronic sleep loss interferes with daily functioning and adversely affects health. The main clinical drugs for insomnia are the positive allosteric modulator of the GABA (gamma-aminobutyric acid) A receptors (GABAARs) at the benzodiazepine site with selectivity of the GABA-α1 receptor.
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