5 results match your criteria: "Xinghua People's Hospital Affiliated to Yangzhou University[Affiliation]"
Unveiling Leydig cell heterogeneity and its role in male infertility: A single-cell transcriptomic study of human testicular tissue.
Reprod Biol
November 2024
Department of Vascular Surgery, Shanghai Geriatric Medical Center, Shanghai, China; Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China; Institute of Vascular Surgery, Fudan University, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China. Electronic address:
Article Synopsis
- Male infertility and impaired spermatogenesis are major reproductive health issues linked to disruptions in testicular cellular and molecular processes.
- This study utilizes single-cell transcriptomic analysis of human testes, revealing unique cell types and interactions often missed in bulk tissue studies.
- Significant findings include disrupted Germ cell differentiation in various infertility conditions and the identification of key transcription factors affecting Leydig cell function, suggesting potential targeted therapies for male infertility.
AMIGO2 characterizes cancer-associated fibroblasts in metastatic colon cancer and induces the release of paracrine active tumorigenic secretomes.
J Pathol
January 2025
Division of Molecular and Experimental Surgery, Department of Surgery, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.
Secretomes of cancer-associated fibroblasts (CAFs) in colorectal cancer (CRC) contribute to malignancy. Detailed knowledge is available on the components and functions of CAF secretomes. Little is known about the regulation of CAF secretomes.
View Article and Find Full Text PDFUnveiling the impact of SUMOylation at K298 site of heat shock factor 1 on glioblastoma malignant progression.
Neoplasia
November 2024
Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, China; Institute of Stroke Research, Soochow University, Suzhou 215006, China. Electronic address:
Article Synopsis
- Glioblastoma (GBM) is a challenging brain cancer characterized by aggressive growth and poor survival rates, where the roles of mitochondrial UPRmt and HSF1 are crucial in its development.
- * The study employed various techniques, including cell cultures and in vivo models, to examine how the SUMOylation of HSF1 affects its function and contributes to GBM's progression.
- * Results showed that SUMOylated HSF1 enhances GBM cell growth and survival by promoting nuclear translocation and activating the UPRmt pathway, suggesting that targeting SUMOylated HSF1 could be a promising therapeutic strategy for GBM.
Mutations and High Prevalence of dMMR-associated Mutational Signatures as Prognostic Indicators in Metastatic Colorectal Cancer.
J Cancer
April 2024
The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, Jiangsu Province,210029, China.
The conventional treatment strategies for patients with metastatic colorectal cancer (mCRC) are predominantly guided by the status of RAS and BRAF mutations. Although patients may exhibit analogous pathological characteristics and undergo similar treatment regimens, notable disparities in their prognostic outcomes can be observed. Therefore, tissue and plasma samples from 40 mCRC patients underwent next-generation sequencing targeting 425 cancer-relevant genes.
View Article and Find Full Text PDF[Prognostic value of admission B-type natriuretic peptide on outcome for patients with congestive heart failure].
Zhonghua Xin Xue Guan Bing Za Zhi
June 2012
Department of Cardiology, Xinghua People's Hospital Affiliated to Yangzhou University, Xinghua 225700, China.
Objective: To observe the prognostic value of admission B-type natriuretic peptide (BNP) on outcome for patients with congestive heart failure (CHF).
Methods: Blood BNP levels, routine echocardiography and tissue Doppler image were obtained in 162 CHF patients [95 male, mean age: (71.8±3.