Continuous Skin Rejuvenation by Combining Nonablative Fractional Laser With Daily Application of a Multibeneficial Composition Formulation: A Blinded Randomized Clinical Trial Study.

Background And Aims: Skin aging is a common concern among individuals, and laser treatments are recognized as one of the most effective approaches to mitigate the aging process. The study aims to compare a multibeneficial formula serum versus a blank formulation in achieving maximum efficacy following a single treatment of nonablative fractional laser for facial skin rejuvenation.

Methods: This study was a double-blind, split-face, monocentric, randomized clinical trial in China (September 24, 2023-March 07, 2024), and 37 patients seeking the Fotona 4D laser treatment for aging-related facial changes were enrolled.