3 results match your criteria: "Xiaogan Center Hospital[Affiliation]"
Modulation of miR-10a-mediated TGF-β1/Smads signaling affects atrial fibrillation-induced cardiac fibrosis and cardiac fibroblast proliferation.
Biosci Rep
February 2019
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
Atrial fibrillation (AF) rat models and rat cardiac fibroblasts (CFs) with overexpressed or inhibited miR-10a were used to investigate the possible role of miR-10a-mediated transforming growth factor-β (TGF-β1)/Smads signaling in cardiac fibrosis and fibroblast proliferation in rats with AF. Gene ontology and pathway enrichment analyses were used to identify the possible function of miR-10a in cardiac fibrosis. The results showed that overexpressed miR-10a significantly prolonged the duration of AF, further elevated the collagen volume fraction (CVF), and increased the viability of CFs in AF rats; these findings were in contrast with the findings for rats with inhibition of miR-10a (all <0.
View Article and Find Full Text PDF[Changes of red cell immune function and T-lymphocyte subsets in children with bronchiolitis].
Zhongguo Dang Dai Er Ke Za Zhi
March 2011
Department of Pediatrics, Xiaogan Center Hospital, Xiaogan, Hubei 432000, China.
Article Synopsis
- The study investigates how bronchiolitis affects red cell immune function and T-lymphocyte subsets in children compared to healthy controls.
- Results show that children with bronchiolitis have lower levels of certain immune markers (RBC-C3bRR and CD8+ cells) but higher levels of others (CD3+, CD4+ cells, and RBC-ICR).
- Findings suggest that the dysfunction in red cell immune mechanisms and T-lymphocyte populations may contribute to the development of bronchiolitis.
[Comparison of the exposure rates of risk factors and inducing factors of acute myocardial infarction between younger and aged adults].
Zhonghua Liu Xing Bing Xue Za Zhi
March 2007
Department of Cardiology, Xiaogan Center Hospital, Xiaogan 432100, China.
Objective: To study the clinical characteristics of acute myocardial infarction (AMI) among younger adults and to explore the possible mechanisms of early myocardial infarction, combined with the newly discovered risk factors of coronary heart disease.
Methods: Data on comparative analysis to the exposure rates of the risk factors and inducing factors of non-CAD patients with two groups of AMI patients including younger adults group (< or =40 years old) and aged adults group (> or =50 years old). Coronary angiography was applied.