6 results match your criteria: "Xiangyang Hospital of Traditional Chinese Medicine (Xiangyang Institute of Traditional Chinese Medicine)[Affiliation]"
METTL3-Induced m6A Modification Enhances Hsa_Circ_0136959 Expression to Impair the Tumor Characteristics of Papillary Thyroid Carcinoma via Accelerating Ferroptosis.
DNA Cell Biol
December 2024
Department of Endocrine, Xiangyang Hospital of Traditional Chinese Medicine (Xiangyang Institute of Traditional Chinese Medicine), Xiangyang, China.
Article Synopsis
- The incidence of papillary thyroid cancer (PTC) is rising, with a focus on the role of circular RNAs (circRNAs) and m6A modifications in cancer progression, particularly in PTC.
- Recent research highlights the circRNA hsa_circ_0136959, which is downregulated in PTC samples and its overexpression can mitigate malignant traits in PTC cells while enhancing ferroptosis-related markers.
- The study also indicates that METTL3 facilitates the expression of hsa_circ_0136959 through m6A modification, linking it to the regulation of tumor characteristics in PTC.
Astragaloside IV confronts amyloid-beta-induced astrocyte senescence via hsp90aa1.
J Appl Biomed
September 2024
Xiangyang Hospital of Traditional Chinese Medicine (Xiangyang Institute of Traditional Chinese Medicine), Department of Anesthesiology, Xiangyang 441000, China.
Article Synopsis
- This study investigates how Astragaloside IV affects astrocyte senescence caused by amyloid-beta, a key factor in aging and neurodegenerative diseases.
- It finds that Astragaloside IV reduces senescence markers and increases neurotrophic growth factors, which may help in protecting brain cells from degeneration.
- The research highlights hsp90aa1 as a potential target for Astragaloside IV, suggesting that manipulating this protein could lead to new treatment strategies for age-related neurological conditions.
Spontaneously ruptured huge hepatic subcapsular hematoma associated with preeclampsia: A case report and literature review.
J Int Med Res
July 2024
Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hepatic subcapsular hematoma (HSH) is an uncommon complication of pregnancy and is associated with elevated rates of maternal and foetal mortality. The rupture of an HSH is a critical situation that necessitates immediate and timely intervention to prevent loss of life. We present here, a case of a spontaneously ruptured massive HSH caused by preeclampsia.
View Article and Find Full Text PDFPotential mechanism of Taohong Siwu Decoction in preventing and treating postoperative delirium in intertrochanteric fracture patients based on retrospective analysis and network pharmacology.
J Orthop Surg Res
June 2024
Department of traumatic orthopedics, Xiangyang Hospital of Traditional Chinese Medicine [Xiangyang Institute of Traditional Chinese Medicine], Xiangyang, 441000, Hubei, China.
Article Synopsis
- Elderly patients with hip fractures face a higher risk of postoperative delirium (POD), which can hinder recovery and quality of life; Taohong Siwu Decoction (THSWD) shows potential in reducing inflammation related to POD.
- A study analyzed data from patients with intertrochanteric fractures to compare outcomes between those receiving THSWD and a control group, focusing on important health markers before and after surgery as well as cognitive status.
- Results indicated that THSWD treatment improved hemoglobin levels and aimed to uncover mechanisms through network pharmacology and molecular docking, supporting its role in managing POD.
Exercise following joint distraction inhibits muscle wasting and delays the progression of post-traumatic osteoarthritis in rabbits by activating PGC-1α in skeletal muscle.
J Orthop Surg Res
May 2024
Department of Traumatic Orthopedics, Xiangyang Hospital of Traditional Chinese Medicine (Xiangyang Institute of Traditional Chinese Medicine), No. 24 Changzheng Road, Xiangyang, Hubei, 441001, China.
Objective: Muscle wasting frequently occurs following joint trauma. Previous research has demonstrated that joint distraction in combination with treadmill exercise (TRE) can mitigate intra-articular inflammation and cartilage damage, consequently delaying the advancement of post-traumatic osteoarthritis (PTOA). However, the precise mechanism underlying this phenomenon remains unclear.
View Article and Find Full Text PDFMechanism of pruritus ani lotion combined with Huajiao-Gancao-Bingpian oil for pruritus ani treatment based on network pharmacology and molecular dynamics.
Postepy Dermatol Alergol
April 2024
Anorectal Department, Xiangyang Hospital of Traditional Chinese Medicine [Xiangyang Institute of Traditional Chinese Medicine], Xiangyang City, Hubei Province, China.
Introduction: Pruritus ani lotion combined with a Chinese medicine formula named Huajiao (Pericarpium Zanthoxyli Bungeani)-Gancao (Radix Glycyrrhizae)-Bingpian (Borneol) is effective in treating pruritus ani.
Aim: To investigate the mechanism of traditional Chinese medicine (TCM) in pruritus ani via network pharmacology and molecular dynamics (MD).
Material And Methods: The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was utilised to screen active ingredients and their corresponding targets.