Efficacy and Safety of Shexiang Baoxin Pill (MUSKARDIA) in Patients with Stable Coronary Artery Disease Across Different Weight Subgroups.

Ethnopharmacological Relevance: Shexiang Baoxin Pill (MUSKARDIA), a traditional Chinese patent medicine, plays a crucial role in both preventing and treating diverse cardiovascular diseases, including coronary heart disease, myocardial infarction (MI), and heart failure. Preclinical research has demonstrated that the cardioprotective effects of MUSKARDIA are achieved through multiple pathways, such as enhancing coronary artery dilation, fostering new blood vessel growth, reducing inflammation and oxidative stress, improving lipid metabolism, and protecting vascular endothelium.

Aim Of The Study: This subgroup analysis aimed to evaluate the efficacy and safety of Shexiang Baoxin Pill (MUSKARDIA) plus optimal medical therapy (OMT) across different weight categories in treating stable coronary artery disease (CAD).

Gut microbes of the cecum versus the colon drive more severe lethality and multi-organ damage.

Intestinal perforations lead to a high risk of sepsis-associated morbidity and multi-organ dysfunctions. A perforation allows intestinal contents (IC) to enter the peritoneal cavity, causing abdominal infections. Right- and left-sided perforations have different prognoses in humans, but the mechanisms associated with different cecum and colon perforations remain unclear.

Three-dimensional printed models improve orthopedic residents' understanding of adolescent idiopathic scoliosis.

Background: Adolescent idiopathic scoliosis, a complex three-dimensional spine deformity, presents a formidable challenge for orthopedic residents in understanding its anatomy and surgical strategies. The aim of this study is to investigate the impact of three-dimensional printing (3DP) models in enhancing the comprehension of adolescent idiopathic scoliosis among orthopedic residents.

Methods: Forty orthopedic residents were randomly divided into two groups, the first group received lectures that were augmented with 3DP models illustrating five cases of adolescent idiopathic scoliosis, along with corresponding X-ray and CT images.

Mitochondrial diseases: from molecular mechanisms to therapeutic advances.

Mitochondria are essential for cellular function and viability, serving as central hubs of metabolism and signaling. They possess various metabolic and quality control mechanisms crucial for maintaining normal cellular activities. Mitochondrial genetic disorders can arise from a wide range of mutations in either mitochondrial or nuclear DNA, which encode mitochondrial proteins or other contents.

Early identification of potentially reversible cancer cachexia using explainable machine learning driven by body weight dynamics: a multicenter cohort study.

Background: Cachexia is associated with multiple adverse outcomes in cancer. However, clinical decision-making for oncology patients at the cachexia stage presents significant challenges.

Objective: This study aims to develop a machine learning (ML) model to identify potentially reversible cancer cachexia (PRCC).

Multilayer network instability underlying persistent auditory verbal hallucinations in schizophrenia.

Background: Auditory verbal hallucinations (AVHs) in schizophrenia (SCZ) are linked to brain network abnormalities. Resting-state fMRI studies often assume stable networks during scans, yet dynamic changes related to AVHs are not well understood.

Methods: We analyzed resting-state fMRI data from 60 SCZ patients with persistent AVHs (p-AVHs), 39 SCZ patients without AVHs (n-AVHs), and 59 healthy controls (HCs), matched for demographics.

Hydroxypropyl methylcellulose remove dense water droplets during fluid-air exchange on the posterior surface of intraocular lenses with posterior capsule loss.

Purpose: The research investigates the efficacy of hydroxypropyl methylcellulose (HPMC) treatment in facilitating the development of compact water droplets on the rear surface of synthetic lenses with capsule imperfections during the process of fluid-air exchange.

Method: This study examined four patients with intraocular lens (IOL) implants and posterior capsule defects who experienced the formation of dense water droplets on the posterior surface following fluid-air exchange. When this occurrence obstructs fundus visualization during surgery, it is recommended to suspend the surgical procedure.

Targeting Enterobacter cloacae attenuates osteolysis by reducing ammonium in multiple myeloma.

Multiple myeloma (MM)-induced bone disease affects not only patients' quality of life but also their overall survival. Our previous work demonstrated that the gut microbiome plays a crucial role in MM progression and drug resistance. However, the role of altered gut microbiota in MM bone disease remains unclear.

Emerging Artificial Synaptic Devices Based on Organic Semiconductors: Molecular Design, Structure and Applications.

In modern computing, the Von Neumann architecture faces challenges such as the memory bottleneck, hindering efficient processing of large datasets and concurrent programs. Neuromorphic computing, inspired by the brain's architecture, emerges as a promising alternative, offering unparalleled computational power while consuming less energy. Artificial synaptic devices play a crucial role in this paradigm shift.

A unique achalasia patient complicated by neuropathies associated with nutritional deficiencies.

This paper reported a rare case of achalasia patient postoperatively experiencing a series of neurologic symptoms, diagnosed as severe B vitamin deficiencies caused by central and peripheral damage.

Therapeutic Effects of Tea Polyphenols on Renal Damage Induced by High Uric Acid.

Background: Hyperuricemia (HUA) is a condition characterized by excessive uric acid production and/or inadequate uric acid excretion due to abnormal purine metabolism in the human body. Uric acid deposits resulting from HUA can lead to complications such as renal damage. Currently, drugs used to treat HUA lack specificity and often come with specific toxic side effects.

Novel antibiotics against without detectable resistance by targeting proton motive force and FtsH.

The increased prevalence of methicillin-resistant (MRSA) and its biofilms poses a great threat to human health. Especially, -related osteomyelitis was hardly cured even by conventional antibiotics combined with surgical treatment. The development of novel structural antibiotics is urgently needed.

Loneliness and Social Isolation with Risk of Incident Non-alcoholic Fatty Liver Disease, UK Biobank 2006 to 2022.

Although loneliness and social isolation are proposed as important risk factors for metabolic diseases, their associations with the risk of non-alcoholic fatty liver disease (NAFLD) have not been elucidated. The aims of this study were to determine whether loneliness and social isolation are independently associated with the risk of NAFLD and to explore potential mediators for the observed associations. In this large prospective cohort analysis with 405,073 participants of the UK Biobank, the status of loneliness and social isolation was assessed through self-administrated questionnaires at study recruitment.

Subgroups of cognitive impairments in schizophrenia characterized by executive function and their morphological features: a latent profile analysis study.

Background: The heterogeneity of cognitive impairments in schizophrenia has been widely observed. However, reliable cognitive boundaries to differentiate the subgroups remain elusive. The key challenge for cognitive subtyping is applying an integrated and standardized cognitive assessment and understanding the subgroup-specific neurobiological mechanisms.

Perfluorinated compounds linked to central precocious puberty in girls during COVID-19: an untargeted metabolomics study.

Background And Objective: The incidence of central precocious puberty (CPP) in girls increased significantly during the COVID-19 pandemic. This study aimed to explore the impact of perfluorinated endocrine disruptors on CPP through metabolomics analysis in girls from Hainan Province, China.

Methods: Serum samples from 100 girls with CPP and 100 healthy controls were collected.

Nonlinear relationship between serum Klotho and chronic kidney disease in US adults with metabolic syndrome.

Background: Current evidence regarding the effects of serum Klotho among patients with metabolic syndrome (MetS) is scarce. This study explored the relationship between serum Klotho levels and the odds of chronic kidney disease (CKD) in middle-aged and older populations with MetS.

Materials And Methods: This cross-sectional study analyzed data from 4870 adults aged 40-79 years who participated in the National Health and Nutrition Survey (NHANES) from 2007 to 2016.

Sesamol Ameliorates Lipid Deposition by Maintaining the Integrity of the Lipid Droplet-Mitochondria Connection in Diabetic Nephropathy.

Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and an important cause of end-stage renal disease (ESRD). However, there is still a lack of effective prevention and treatment strategies in clinical practice. As a metabolic disease, DN is accompanied by renal ectopic lipid deposition, and the deposited lipids further aggravate kidney injury.

Brain Imaging and Cognitive Deficits in Psychiatric Disorders.

Over the last three decades, various neuroimaging techniques, such as magnetic resonance imaging (MRI), functional MRI, and positron emission tomography (PET), have played an essential role in improving our understanding of the pathogenesis of neuropsychiatric disorders [...

Aberrant controllability of functional connectome during working memory tasks in patients with schizophrenia and unaffected siblings.

Background: Working memory deficit, a key feature of schizophrenia, is a heritable trait shared with unaffected siblings. It can be attributed to dysregulation in transitions from one brain state to another.

Aims: Using network control theory, we evaluate if defective brain state transitions underlie working memory deficits in schizophrenia.

Comparison of en-bloc direct vertebrae rotation and non-direct vertebrae rotation for the correction of adolescent idiopathic scoliosis Lenke 5C: a retrospective study in Changsha, China.

Study Design: A retrospective study.

Purpose: This study aimed to compare the clinical effectiveness of en-bloc direct vertebrae rotation (DVR) to non-DVR for the correction of Lenke 5C.

Overview Of Literature: The primary goal of posterior correction is to preserve the lumbar spine and achieve a well-balanced spine.

COPD-ES Questionnaire Based COPD Patients Management in Stable Phrase Improves Disease Group Classification.

Introduction: Chronic obstructive pulmonary disease (COPD) is a prevalent, incurable condition requiring lifelong management. Inadequate daily management exacerbates COPD, leading to increased healthcare utilization and reduced quality of life.

Methods: This study aimed to design and validate a 10-item COPD self-evaluation (COPD-ES) questionnaire and apply it in the education of stable COPD patients.