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Characterization of ATPase Activity of P2RX2 Cation Channel.

Front Physiol

June 2016

Department of Otolaryngology, University of Miami Miller School of MedicineMiami, FL, USA; Department of Biochemistry, University of Miami Leonard M. Miller School of MedicineMiami, FL, USA; Department of Otolaryngology, Central South University, Xiangya HospitalChangsha, China.

P2X purinergic receptors are plasma membrane ATP-dependent cation channels that are broadly distributed in the mammalian tissues. P2RX2 is a modulator of auditory sensory hair cell mechanotransduction and plays an important role in hair cell tolerance to noise. In this study, we demonstrate for the first time in vitro and in cochlear neuroepithelium, that P2RX2 possesses the ATPase activity.

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