Efficacy and safety of ZX-7101A, an inhibitor of influenza cap-dependent endonuclease, in adults with uncomplicated influenza: a randomized, double-blind, placebo-controlled phase 2/3 trial.

Objectives: To evaluate the efficacy and safety of ZX-7101A: an inhibitor of influenza viral cap-dependent endonuclease, in adults with uncomplicated influenza and explore treatment-emergent resistance.

Methods: We conducted a randomized, double-blind, placebo-controlled, adaptive-design phase 2 and phase 3 studies (ZX-7101A-202) in adults with uncomplicated influenza. Eligible patients were randomized 1:1:1 to receive a single dose of 40 or 80 mg ZX-7101A or placebo, stratified by body weight and baseline composite symptom score.

Brain glycogen: A key to revealing the pathology of mental diseases.

Brain glycogen, which is distinct from muscle glycogen and liver glycogen, has become a crucial node linking metabolism, epigenetics, and autophagy. Recent studies have suggested that brain glycogen governs multiple neurobehavioral processes, such as memory formation and consolidation. However, the changes in brain glycogen levels in mental diseases and the associations of these changes with the disease prognosis are unknown.

Association between rheumatoid arthritis and serum vitamin C levels in Adults: Based on the National health and Nutrition Examination survey database.

This study attempted to investigate relationship between rheumatoid arthritis and serum vitamin C levels using data from National Health and Nutrition Examination Survey (NHANES). The NHANES database aims to collect health, nutrition, biological, and behavioral data from a nationally representative sample of the population. This study utilizes NHANES data from three cycles: 2003-2004, 2005-2006, and 2017-2018, extracting data on the prevalence of rheumatoid arthritis and serum vitamin C levels.

CD147 regulates the formation and function of immune synapses.

CD147 is a T cell activation-associated molecule which is closely involved in the formation of the immune synapse (IS). However, the precise role of CD147 in T cell activation and IS formation remains unclear. In the present study, we demonstrated that CD147 translocated to the IS upon T cell activation and was primarily distributed in the peripheral super molecular cluster (p-SMAC).

Study on the Relationship between Lung Cancer Stromal Cells and Air Cavity Diffusion Based on an Image Acquisition System.

Objective: The study aimed to investigate the role of tumor stromal cells in the pathogenesis of STAS, the relationship between air diffusion (STAS) and tumor stromal cells (TSCs) was studied, and the prognostic significance of TSC and STAS in patients with lung adenocarcinoma was evaluated.

Methods: A total of 150 patients with lung cancer diagnosed in the Affiliated Hospital of Jiangsu Province were selected. From the perspective of pathology, medical information technology was used to assist the diagnosis.

Role of Knowledge Management on the Sustainable Environment: Assessing the Moderating Effect of Innovative Culture.

Environmental sustainability has become the need of the hour and has been emphasized immensely because of the increased environmental awareness and resulting problems caused due to negligence. This study has intended to determine the role of knowledge management (KM) practices in achieving a sustainable environment with the mediating role of environmental awareness and green technological use. The study further examined the moderating role of green innovative culture between the relationship of KM practices and a sustainable environment.

Association between Congenital Cytomegalovirus Infection and Brain Injury in Neonates: A Meta-analysis of Cohort Studies.

Objective: To assess association between congenital cytomegalovirus (CMV) infection and brain injury in neonates.

Methods: The literatures from inception to November 4, 2020, were searched through PubMed, Embase, Cochrane Library, and Web of Science. Heterogeneity test was conducted for each indicator and measured by statistics.

GARP Correlates With Tumor-Infiltrating T-Cells and Predicts the Outcome of Gastric Cancer.

Accepting the crucial role of the immune microenvironment (TME) in tumor progression enables us to identify immunotherapeutic targets and develop new therapies. Glycoprotein A repetitions predominant (GARP) plays a vital part in maintaining regulatory T cell (Treg)-mediated immune tolerance. The impact of GARP in TME of gastric cancer is still worth exploring.

Effects of CD100 promote wound healing in diabetic mice.

Diabetes is a condition that causes delayed wound healing and results in chronic wounds. CD100 has been reported to promote and induce potent and obvious angiogenesis both in vivo and in vitro studies, the absence of which are a main cause of the diabetic chronic wound. In the present study, we investigated the effects of application of soluble CD100 on wound healing in diabetic mice.

Penehyclidine hydrochloride postconditioning ameliorates cerebral ischemia-reperfusion injury: critical role of mitochondrial ATP sensitive potassium channel.

Cerebral ischemia/reperfusion (CI/R) leads to disability and death worldwide. However, limited approaches have been made in developing therapies to decrease the detrimental effects of CI/R. In the present study, we evaluated the effects of penehyclidine hydrochloride (PHC) postconditioning on CI/R injury and elucidated the underlying mechanisms.

Equol increases cerebral blood flow in rats via activation of large-conductance Ca(2+)-activated K(+) channels in vascular smooth muscle cells.

The present study was designed to investigate the effect of equol on cerebral blood flow and the underlying molecular mechanisms. The regional cerebral blood flow in parietal lobe of rats was measured by using a laser Doppler flowmetry. Isolated cerebral basilar artery and mesenteric artery rings from rats were used for vascular reactivity measurement with a multi wire myography system.

Electrolytic lesions of the bilateral ventrolateral orbital cortex inhibit methamphetamine-associated contextual memory formation in rats.

The memories that are formed between rewarding and drug-associated contextual cues have been suggested to contribute to drug addiction relapse. Recent evidence has indicated that the ventrolateral orbital cortex (VLO) plays important roles in reward-based learning and reversal learning. However, whether the VLO is required for methamphetamine-induced contextual memory formation is not well understood.

Apolipoprotein B, the villain in the drama?

Low-density lipoprotein (LDL) is the major atherogenic lipoprotein and the primary target of lipid-lowering therapy for treating ischemic cardiovascular disease. Apolipoprotein B (apoB), an important structural component of LDL, plays a key role in cholesterol transport and removal in vascular wall. On the other hand, under pathological process, apoB interacts with the arterial wall to initiate the cascade of events that leads to atherosclerosis.

Role of the Akt/GSK-3β/CRMP-2 pathway in axon degeneration of dopaminergic neurons resulting from MPP+ toxicity.

Parkinson׳s disease (PD) is the most common neurodegenerative disease of the basal ganglia. Earlier reports suggest that the main pathological change in PD is due to apoptosis of dopaminergic neuronal soma in the substantia nigra (SN). The therapies for PD are also largely focused on the prevention of degeneration of the neuronal soma.

Expression of neurogranin in hippocampus of rat offspring exposed to restraint stress and pulsed magnetic fields.

Stressor acting upon the organism during pregnancy can produce distinct and long lasting effects on the offspring. However, the essential mechanism remains unclear. Neurogranin (Ng) is a postsynaptic brain-specific protein involved in the regulation of calcium signaling and neuronal plasticity.

[Production of HPV 16 major capsid protein L1 with baculovirus expression system].

Background: To obtain human papillomavirus type 16(HPV 16) major capsid protein L1 with baculovirus expression system.

Methods: Using pFb1 as a vector,a recombinant baculovirus expressing plasmid,which contains HPV16L1 gene sequence,was generated. The constructed virus was infected into an insect cell line Sf9.

[Construction, eukaryotic expression and biological activities of a recombinant human single chain interleukin-12 fusion gene].

Objective: To explore the feasibility of recombinant human interleukin 12 (IL-12) with biological activities by molecular biological techniques.

Method: Both p40 and p35 subunits cDNA of human IL-12 were cloned from mRNA extracted from NC-37 cell line by using RT-PCR, and the fusion gene (p40-linker-p35) of recombinant human single chain IL-12 (rhscIL-12) was constructed by using a polypeptide linker (Gly(4)Ser)(3). rhscIL-12 eukaryotic expressing vector pcDNA3.

[Human DNA polymorphism of HaeIII system in Chinese oriental, Han population].

DNA typing by restriction fragment length polymorphism (RFLP) analysis was an extremely important technique used in forensic science identification, paternity test and gene diagnosis. While RFLP testing was a highly informative method, it traditionally had several disadvantages. It was time consuming and involved in working with radioactive phosphorus.

[Distribution of K5, K10 in transgenic mouse with lac Z reporter gene].

Objective: To detect the distribution of K5, K10 in live mouse.

Methods: lacZ gene, which encodes beta-galactosidase, as a reporter gene, bovine K5, K10 as promoter, containing Sal I fragment, was inserted into the Sal I sites of PLGZ and PLBS-2, respectively. The constructs were microinjected into the mice fertilized eggs, and then PCR positive ones were kept.

[Anatomic study of the facial nerve in parotidectomy].

To explore the course and anatomic characteristics of the extra-cranial section of the facial nerve, the authors carried out this clinical study in 120 patients undergoing parotidectomy by dissecting and measuring the facial nerve and its branches regarding its length, diameter and numbers. The results confirmed that the temporal branch is deeper and has multiple branches; the zygomatic branch is bigger, with consistent location and fewer branches; the buccal branch exhibits three patterns: 1. the upper and lower branches, 2.

The expression of cadherin-catenin complex in association with the clinicopathologic features of early gastric cancer.

Although impaired expression of E-cadherin (E-cad) is frequently observed in tumors with aggressive histopathologic characteristics, the correlation between alpha-catenin (alpha-cat) expression and the clinicopathologic features of early gastric cancer have not been fully examined. In this study, we evaluated the expression of E-cad and alpha-cat by early gastric carcinomas, and examined the relationships between this expression and various clinicopathologic characteristics. A total of 69 specimens obtained from surgery were studied by immunohistochemistry.

[Blood pressure responses to cold pressor stress and its relation to sodium metabolism in salt-sensitive children].

Objective: To investigate the blood pressure responses to cold pressor stress and its relation to sodium metabolism in salt-sensitive children.

Method: 268 children aged 10.6 +/- 1.

[Study on polysaccharide of Lobaria kurokauae].

LOK polysaccharide is isolated from Lobaria kurokauae. By chromatography, LOK is shown to be sing substance. By gas chromatography analysis, LOK composes of rhamnose, arabinose, xylose, mannose, glucose and galactose.

[Effects of total flavones of fructus Hippophae (TFH) on cardiac function and hemodynamics of anesthetized open-chest dogs with acute heart failure].

This study was carried out employing the model of dog with acute heart failure induced by phenobarbital natricum. It was shown that i.v.