Neointimal hyperplasia after endoluminal injury in mice is dependent on tissue factor- and angiopoietin-2 dependent interferon gamma production by fibrocytes and macrophages.

Background: The intimal hyperplasia (IH) and vascular remodelling that follows endovascular injury, for instance after post-angioplasty re-stenosis, results in downstream ischaemia and progressive end organ damage. Interferon gamma (IFNγ) is known to play a critical role in this process. In mouse models we have previously shown that fibrocytes expressing tissue factor (TF) are recruited early to the site of injury.

Dynamic Rotational Sensor Using Polymer Optical Fiber for Robot Movement Assessment Based on Intensity Variation.

A complex signal processing technique is usually required to process the data in most sensor design structures, and integration into real applications is also challenging. This work presents a dynamic rotational sensor using polymethyl methacrylate (PMMA) fiber for robot movement assessment. The sensor design structure is based on the coupling of light intensity, in which two PMMA fibers are twisted together.

Antiphase response of the Indonesian-Australian monsoon to millennial-scale events of the last glacial period.

Antiphase behaviour of monsoon systems in alternate hemispheres is well established at yearly and orbital scales in response to alternating sensible heating of continental landmasses. At intermediate timescales without a sensible heating mechanism both in-phase and antiphase behaviours of northern and southern hemisphere monsoon systems are recorded at different places and timescales. At present, there is no continuous, high resolution, precisely dated record of millennial-scale variability of the Indonesian-Australian monsoon during the last glacial period with which to test theories of paleomonsoon behaviour.

The brain structure and function abnormalities of migraineurs: A systematic review and neuroimaging meta-analysis.

Objectives: To quantitatively summarize the specific changes in brain structure and function in migraine patients.

Methods: A literature screening of migraine was conducted from inception to Sept 1, 2022, in PubMed, Web of Science, Cochrane Library, and Medline databases using the keyword combination of "migraine and MRI." Activation likelihood estimation (ALE) was performed to assess the differentiation of functional connectivity (FC), regional homogeneity (ReHo), and gray matter volume (GMV) of migraine patients.

Clinical features and antibiotic treatment of early-onset neonatal listeriosis.

Objective: To analyze the clinical features, efficacy of antibiotic treatment, and outcome of neonatal listeriosis.

Methods: This was a retrospective study that included all neonates diagnosed with listeriosis between January 2010 and December 2021.

Results: Nine male patients and five female patients were analyzed, including 11 preterm and 3 term infants.

Droughts and societal change: The environmental context for the emergence of Islam in late Antique Arabia.

In Arabia, the first half of the sixth century CE was marked by the demise of Himyar, the dominant power in Arabia until 525 CE. Important social and political changes followed, which promoted the disintegration of the major Arabian polities. Here, we present hydroclimate records from around Southern Arabia, including a new high-resolution stalagmite record from northern Oman.

Self-reported chronic kidney disease and the risk of all-cause and cause-specific mortality: outcome-wide association study of 54 causes of death in the National Health Interview Survey.

Background: A diagnosis of chronic kidney disease has been strongly associated with cardiovascular disease and mortality in a number of studies, but the association with specific causes of death has not been assessed in detail. We analysed the association between chronic kidney disease and all-cause mortality and 54 causes of death in the National Health Interview Survey, a prospective study of 210,748 US adults.

Methods: We used multivariable Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and cause-specific mortality associated with self-reported chronic kidney disease.

Facile Synthesis and Electrochemical Studies of MnO/Graphene Composite as an Electrode Material for Supercapacitor Application.

A simplified sol-gel method that can be scaled up for large-scale production was adopted for the preparation of manganese oxide nanocrystals. Prepared MnO exhibited micron-sized particles with a nanoporous structure. In the present study, a simple and low-cost strategy has been employed to fabricate nanoporous MnO with an increased surface area for an electrode/electrolyte interface that improved the conduction of MnO material.

The discerning eye of computer vision: Can it measure Parkinson's finger tap bradykinesia?

Objective: The worldwide prevalence of Parkinson's disease is increasing. There is urgent need for new tools to objectively measure the condition. Existing methods to record the cardinal motor feature of the condition, bradykinesia, using wearable sensors or smartphone apps have not reached large-scale, routine use.

Can the Novel LumboIliac Triangle Technique Based on Biplane Oblique Fluoroscopy Facilitate Transforaminal Percutaneous Endoscopic Lumbar Discectomy for Patients with L5-S1 Disc Herniation Combined with High Iliac Crest? Case-Control Study of 100 Patients.

Background: Percutaneous endoscopic lumbar discectomy (PELD) via the transforaminal approach is difficult at L5-S1 in patients presenting with high iliac crests (HIC). The conventional wisdom is that measurement using lumbar radiography, computed tomography (CT), or magnetic resonance imaging (MRI) is necessary.

Objectives: The objective of this study was to introduce a lumbo-iliac triangular (LI-Tri) technique based on biplane oblique fluoroscopy and verify whether it facilitated transforaminal PELD for patients with L5-S1 lumbar disc herniation (LDH) combined with HIC.

Cocktail Treatment with a Gelatin Sponge Impregnated with Ropivacaine, Dexamethasone, and Vitamin B12 Promotes Early Postoperative Recovery after Percutaneous Endoscopic Lumbar Discectomy: A Retrospective, Case-Controlled Study.

Background: Percutaneous endoscopic lumbar discectomy (PELD) can only relieve mechanical compression but cannot directly reduce the inflammatory reaction of the adjacent nerve root, which contributes to persistent pain and physical disabilities postoperatively. Numerous studies have explored the application of epidural steroids after an open lumbar discectomy in relieving pain by reducing local inflammatory reactions and further peridural scar formation.

Objectives: To explore that whether "cocktail treatment" in which a gelatin sponge was impregnated with ropivacaine, dexamethasone, and vitamin B12 promoted early postoperative recovery after PELD.

Causes of Residual Back Pain at Early Stage After Percutaneous Vertebroplasty: A Retrospective Analysis of 1,316 Cases.

Background: Percutaneous vertebroplasty (PVP) is now well accepted in the treatment of painful osteopathic vertebral compression fractures (OVCF), providing early pain relief and strengthening of the bone of the vertebrae. However, some patients still experienced severe back pain after PVP.

Objectives: To analyze the possible reason for unsatisfactory back pain relief (UBPR) after PVP at early stage.

Central Europe temperature constrained by speleothem fluid inclusion water isotopes over the past 14,000 years.

The reasons for the early Holocene temperature discrepancy between northern hemispheric model simulations and paleoclimate reconstructions-known as the Holocene temperature conundrum-remain unclear. Using hydrogen isotopes of fluid inclusion water extracted from stalagmites from the Milandre Cave in Switzerland, we established a mid-latitude European mean annual temperature reconstruction for the past 14,000 years. Our Milandre Cave fluid inclusion temperature record (MC-FIT) resembles Greenland and Mediterranean sea surface temperature trends but differs from recent reconstructions obtained from biogenic proxies and climate models.

Label-Free Visualization of Carbapenemase Activity in Living Bacteria.

Evaluating enzyme activity intracellularly on natural substrates is a significant experimental challenge in biomedical research. We report a label-free method for real-time monitoring of the catalytic behavior of class A, B, and D carbapenemases in live bacteria based on measurement of heat changes. By this means, novel biphasic kinetics for class D OXA-48 with imipenem as substrate is revealed, providing a new approach to detect OXA-48-like producers.

Sentinel lymph node mapping in gynecological oncology.

The intraoperative mapping of sentinel lymph nodes (SLNs) is part of the treatment strategy for a number of types of tumor. To retrospectively compare results from the mapping of pelvic SLNs for gynecological oncology, using distinct dyes, the present review was conducted to determine the clinical significance of SLN mapping for gynecological oncology. In addition, the present study aimed at identifying an improved choice for SLN mapping tracers in clinical application.

Factors Affecting Delayed Union of Vertebral Fractures Following Percutaneous Kyphoplasty.

Background: Although percutaneous kyphoplasty (PKP) could achieve rapid pain relief for the elderly with osteoporotic vertebral compression fracture (OVCF), some patients still had risks of suffering vertebrae delayed union which led to persisting pain and vertebral collapse. Preventing the delayed vertebral union could reduce the further morbidities and medical costs for patients with OVCF after PKP.

Objectives: To explore the factors involved in delayed vertebral union after PKP in patients with OVCF.

Avoiding Optimal Mean ℓ-Norm Maximization-Based Robust PCA for Reconstruction.

Robust principal component analysis (PCA) is one of the most important dimension-reduction techniques for handling high-dimensional data with outliers. However, most of the existing robust PCA presupposes that the mean of the data is zero and incorrectly utilizes the average of data as the optimal mean of robust PCA. In fact, this assumption holds only for the squared [Formula: see text]-norm-based traditional PCA.

Association of multiple genetic variants with breast cancer susceptibility in the Han Chinese population.

We selected 13 tag single nucleotide polymorphisms (tSNPs) to investigate whether they were associated with breast cancer risk in the Chinese Han population. Upon statistical analyses of clinical data from 551 patients and 577 controls, we found that six of the 13 SNPs were associated with breast cancer; namely, rs4973768(Odds ratio (OR) = 1.30, 95% confidence interval (CI) =1.

Percutaneous Kyphoplasty Evaluated by Cement Volume and Distribution: An Analysis of Clinical Data.

Background: Percutaneous kyphoplasty (PKP) could achieve rapid pain relief for older patients with osteoporotic vertebral compression fractures (OVCFs). Bone cement in PKP was the key factor keeping the stabilization of the vertebral body. However, the same amount of cement can distribute differently in a vertebral body and can thereby result in different surgery outcomes.

Protective effect of cannabidiol on hydrogen peroxide‑induced apoptosis, inflammation and oxidative stress in nucleus pulposus cells.

Cannabidiol, a major component of marijuana, protects nerves, and exerts antispasmodic, anti-inflammatory and anti‑anxiety effects. In the current study, the protective effect of cannabidiol was observed to prevent hydrogen peroxide (H2O2)‑induced apoptosis, inflammation and oxidative stress in nucleus pulposus cells. Nucleus pulposus cells were isolated from rats and cultured in vitro, and H2O2 was used to construct the nucleus pulposus cell model.

[Physical exercise improves erectile function in young and middle-aged men].

Objective: To assess the association between physical exercise and erectile function in young and middle-aged men.

Methods: Using Paffenbarger Physical Activity Questionnaire (PPAQ) and IIEF-15, we conducted an investigation among 30- to 45-year-old male outpatients at the clinic of urology. Based on the physical activity described in PPAQ, the patients were divided into a sedentary group (≤ 1,400 Kcal/wk) and an exercise group (> 1,400 Kcal/wk).