Insights into the functional mechanisms of the sesquiterpene synthase GEAS and GERDS in lavender.

Lavenders are economically significant plants cultivated worldwide for their essential oils (EOs) containing sesquiterpenes. These EOs contribute to the cosmetic, personal hygiene, and pharmaceutical industries. The biosynthesis of lavender sesquiterpenes involves enzymes like sesquiterpene synthases GEAS and GERDS.

Poly(lactic acid)-based materials with enhanced gas permeability for modified atmosphere packaging of Chinese bayberry.

Biodegradable plastics are increasingly utilized in packaging, driven by green chemistry and environmental responsibility. Among them, poly(L-lactic acid) (PLLA) stands out due to its biodegradability and biocompatibility. However, its limited gas permeability and selectivity hinder its application in produce preservation.

Detecting mitochondrial hypochlorous acid and viscosity in atherosclerosis models via NIR fluorescent probes.

The assessment of early atherosclerosis (AS) via fluorescence imaging is crucial for advancing early diagnosis research. Abnormal inflammation biomarkers, including hypochlorous acid (HClO) and viscosity within mitochondria, have been closely linked to the pathogenesis of AS. However, current fluorescent probes predominantly rely on unimodal imaging that targets a single biomarker and lacks mitochondrial specificity, which can result in potential false signal readouts due to the complex intracellular environment.

Metaproteomics reveals metabolic activities potentially involved in bloom formation and succession during a mixed dinoflagellate bloom of Prorocentrum obtusidens and Karenia mikimotoi.

Understanding metabolic activities involved in bloom formation during a single-species algal bloom has improved greatly. However, little is known about metabolic activities during a multi-species algal bloom. Here, we investigated protein expression profiles at different bloom stages of a mixed dinoflagellate bloom caused by Karenia mikimotoi and Prorocentrum obtusidens (syn.

One-step antifouling coating of polystyrene using engineered polypeptides.

Unwanted nonspecific adsorption caused by biomolecules influences the lifetime of biomedical devices and the sensing performance of biosensors. Previously, we have designed B-M-E triblock proteins that rapidly assemble on inorganic surfaces (gold and silica) and render those surfaces antifouling. The B-M-E triblock proteins have a surface-binding domain B, a multimerization domain M and an antifouling domain E.

Fabrication of oat β-glucan-starch composite systems by sequential extraction as batters for deep-fried mushrooms to prevent oil penetration.

Deep-fat frying (DF) of mushrooms is favored by consumers due to its appealing sensory characteristics. However, their high oil absorption can lead to obesity and elevated cholesterol levels. Therefore, developing healthy food coatings as oil barriers and water-holding layers is essential.

Visualizing enterohepatic circulation in vivo by sensitive F MRI with a fluorinated ferrous chelate-based small molecule probe.

Enterohepatic circulation (EHC) is a critical biological process for the normal regulation of many endogenous biomolecules and the increased retention of various exogenous substances. The status of EHC is closely related to the ordinary functioning of several digestive organs. However, it remains a challenge to achieve in vivo real-time visualization of this process.

ANKRD11 binding to cohesin suggests a connection between KBG syndrome and Cornelia de Lange syndrome.

Ankyrin Repeat Domain-containing Protein 11 () is a causative gene for KBG syndrome, a significant risk factor for Cornelia de Lange syndrome (CdLS), and a highly confident autism spectrum disorder gene. Mutations of lead to developmental abnormalities in multiple organs/tissues including the brain, craniofacial and skeletal bones, and tooth structures with unknown mechanism(s). Here, we find that ANKRD11, via a short peptide fragment in its N-terminal region, binds to the cohesin complex with a high affinity, implicating why mutation can cause CdLS.

Molecular and Immunological Characterization of Troponin C: An Allergen from .

, a crustacean of substantial importance, is a frequent trigger of food allergies. This study examined the molecular and immunological properties of troponin C from (Scy p TnC) as an allergen. The findings indicated that thermal stability of Scy p TnC comprised 150 amino acids and facilitated the induction of CD63/CD203c in basophils from crab allergy patients.

The Training and Evaluation of the "Dual-Index" Screening Method for Neonatal Congenital Heart Disease: A Multi-Center Study in China.

Background: This study aimed to enhance the scope of neonatal congenital heart disease (CHD) screening by evaluating the effectiveness of training personnel in CHD screening using the "dual-index" method, combining pulse oximetry with cardiac murmur auscultation.

Methods: From 2019 to 2022, a total of 2374 screening personnel from the Xinjiang, Yunnan, Hainan, Fujian, and Anhui provinces underwent training in neonatal CHD screening using the "dual-index" method, which involves pulse oximetry and cardiac murmur auscultation. Pre- and post-training assessments were conducted using a neonatal CHD screening knowledge questionnaire, distributed through the Questionnaire Star platform, to evaluate the impact of the training.

The impact of hysterectomy for benign uterine tumors on subsequent ovarian reserve, lower urinary tract symptoms, and sexual function: A prospective multidirectional short-term analysis.

Objective: To evaluate the effects of hysterectomy for benign uterine tumors on subsequent ovarian reserve, sexual function, and lower urinary tract symptoms (LUTS).

Methods: The present study was a prospective longitudinal analysis that recruited patients aged 35-45 years who underwent simple hysterectomy without oophorectomy for symptomatic benign uterine tumors. Anti-Müllerian hormone (AMH) and serum sex hormone profiles, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone, and total testosterone, were measured at four timepoints: before hysterectomy, and 3, 6, and 12 months postoperatively.

Unlocking HFIP for Fluoroalkylation with Molecular Photoelectrocatalysis.

Despite the increasing interest in radical-based fluoroalkylation techniques, the organofluorine compounds bearing the partially fluorinated hexafluoroisopropyl group remain extremely scarce due to the lack of appropriate reagents. Herein we report an unprecedented photoelectrocatalytic method for the C-H hexafluoroisopropylation of indoles and tryptophan peptides, utilizing the readily available hexafluoro-2-propanol (HFIP) as the fluoroalkylation reagent. In this process, HFIP is converted into hexafluoroisopropyl radicals, enabling fluoroalkylation reactions.

Pelvic Radiotherapy in Rectal Cancer Patients With Synchronous Potentially Treatable Liver Metastases.

Background: The optimal management strategy for Stage IV rectal cancer with potentially treatable liver metastases remains controversial, particularly regarding the role of pelvic radiotherapy (RT).

Aims: We intend to investigate the impact of pelvic RT on oncological outcomes of rectal cancer with potentially treatable liver metastasis.

Methods And Results: This retrospective study included 83 patients diagnosed with rectal cancer and synchronous liver metastases from June 2012 to January 2022.

sRNA113 regulates motility to affect immune response against infection in pearl gentian grouper.

Small RNAs (sRNAs) are a class of molecules capable of perceiving environmental changes and exerting post-transcriptional regulation over target gene expression, thereby influencing bacterial virulence and host immune responses. is a pathogenic bacterium that poses a significant threat to aquatic animal health. However, the regulatory mechanisms of sRNAs in .

Transposable elements shape the landscape of heterozygous structural variation in a bird genome.

Avian genomes exhibit compact organization and remarkable chromosomal stability. However, the extent and mechanisms by which structural variation in avian genomes differ from those in other vertebrate lineages are poorly explored. This study generated a diploid genome assembly for the golden pheasant ( ), a species distinguished by the vibrant plumage of males.

Personalized Respiratory Motion Modeling Incorporating Longitudinal Data through Two-stage Transfer Learning.

Purpose: This study aims to develop an accurate image registration framework for personalized respiratory motion modeling.

Methods: The proposed framework incorporates longitudinal data through a two-stage transfer learning approach. In the first stage, transfer learning is employed on longitudinal data collected from the same device.

Decision Regret About Treatment Amongst Women With Early Breast Cancer: An Integrative Review.

Aims: To synthesise evidence on decision regret about treatment amongst women with early breast cancer, including (1) the type of treatment related to decision regret, (2) the level of decision regret, and (3) factors associated with decision regret.

Design: Integrative review.

Methods: Studies published between January 2000 and December 2023 were searched from five online databases to provide up-to-date evidence.

Deciphering the potential ability of DExD/H-box helicase 60 (DDX60) on the proliferation, diagnostic and prognostic biomarker in pancreatic cancer: a research based on silico, RNA-seq and molecular biology experiment.

Background: Pancreatic cancer is one of the most malignant abdominal tumors. DDX60 has been shown to be associated with a variety of tumor biological processes. However, DDX60 in pancreatic cancer has not been reported.

The development of rapid detection techniques for Alexandrium catenella.

Alexandrium catenella is an important toxic algal species in the Alexandrium genus, which can form toxic red tides in large numbers. The paralytic shellfish poisoning (PSP) produced by Alexandrium catenella can seriously endanger human health and threaten the production and development of the aquaculture and fishery industries. Therefore, it is important to explore and develop effective detection and early warning methods for toxic red tides.

Modular access to saturated bioisosteres of anilines via photoelectrochemical decarboxylative C(sp)-N coupling.

In drug development, the substitution of benzene rings in aniline-based drug candidates with saturated bridged bicyclic ring systems often enhances pharmacokinetic properties while preserving biological activity. However, current efforts predominantly focuses on bicyclo[1.1.

Cell adhesion molecule protocadherin-γC5 ameliorates Aβ plaque pathogenesis by modulating astrocyte function in Alzheimer's disease.

Accumulation of astrocytes around β-amyloid (Aβ) plaques is one of the earliest neuropathological changes in Alzheimer's disease (AD), but the underlying mechanisms and significance remain unclear. Cell adhesion molecule protocadherin-γC5 (Pcdh-γC5) has been reported to implicate in AD. Here we find elevated expression level of Pcdh-γC5 in the brain of 5×FAD mice and Aβ-treated astrocytes, and further reveal that Pcdh-γC5 deficiency leads to exacerbated Aβ deposition in 5×FAD mice.

Dapagliflozin plus calorie restriction for remission of type 2 diabetes: multicentre, double blind, randomised, placebo controlled trial.

Objective: To assess the effect of dapagliflozin plus calorie restriction on remission of type 2 diabetes.

Design: Multicentre, double blind, randomised, placebo controlled trial.

Setting: 16 centres in mainland China from 12 June 2020 to 31 January 2023.

Acrylpimaric acid-modified chitosan derivatives as potential antifungal agents against Valsa Mali.

In order to the antifungal activity of chitosan (CS) and to obtain a better natural bio-antimicrobial agent, CS was modified with acrylpimaric acid (APA). The grafting sites of APA on CS were controlled by adjusting the reaction time and the ratio of reactants to obtain APA grafted with CS C-NH (NCSAA) and C-OH (CSAA). Intermediates to protect C-NH (PMCSAA) and final sample derivatives (PCSAA) were prepared using phthalic anhydride.

[Evaluation of pharyngeal and laryngeal squamous cell carcinoma after neoadjuvant immunochemotherapy by narrow band imaging].

To investigate the changes in the narrow band imaging (NBI) phenotypes of oropharyngeal, hypopharyngeal, and laryngeal squamous cell carcinoma after neoadjuvant immunochemotherapy, and to explore the clinical value of NBI endoscopy in re-evaluation and follow-up of pharyngeal and laryngeal squamous cell carcinoma after neoadjuvant immunochemotherapy. Twenty-nine patients diagnosed with locally advanced pharyngeal or laryngeal squamous cell carcinoma in the First Affiliated Hospital of Xiamen University from November 2021 to January 2024 and receiving 2 cycles of neoadjuvant immunochemotherapy were selected, including 26 males and 3 females, aged 43-80 years. Regular NBI and white light (WL) endoscopy examinations, as well as imaging examinations such as CT scans, were performed.

Do compression garments enhance running performance? An updated systematic review and meta-analysis.

Background: Despite the wide use of compression garments to enhance athletic running performance, evidence supporting improvements has not been conclusive. This updated systematic review and meta-analysis of randomized controlled trials (RCTs) compared the effects of compression garment wearing with those of non-compression garment wearing (controls) during running on improving running performance.

Methods: A comprehensive search was conducted in the electronic databases (Web of Science, EBSCOhost, PubMed, Embase, Scopus, and Cochrane) for RCTs comparing running performance between runners wearing compression garments and controls during running, from inception to September 2024.