2 results match your criteria: "Xi'an Jiaotong University 710049 Xi'an Shaanxi China fengxu@mail.xjtu.edu.cn feili@mail.xjtu.edu.cn.[Affiliation]"
Correction: monitoring of functional activity of extracellular matrix stiffness-dependent multidrug resistance protein 1 using scanning electrochemical microscopy.
Chem Sci
September 2022
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University 710049 Xi'an Shaanxi China
[This corrects the article DOI: 10.1039/D2SC02708A.].
View Article and Find Full Text PDFmonitoring of functional activity of extracellular matrix stiffness-dependent multidrug resistance protein 1 using scanning electrochemical microscopy.
Chem Sci
September 2022
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University 710049 Xi'an Shaanxi China
Extracellular matrix (ECM) stiffness affects the drug resistance behavior of cancer cells, while multidrug resistance protein 1 (MRP1) on the cell membrane confers treatment resistance actively transporting drugs out of cancer cells. However, the relationship between ECM stiffness and MRP1 functional activity in cancer cells remains elusive, mainly due to the technical challenge of monitoring. Herein, we engineered cancer cell models using breast cancer cells (MCF-7 and MDA-MB-231 cells) as the reprehensive cells on polyacrylamide (PA) gels with three stiffness, mimicking different developmental stages of cancer.
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