Myeloid zinc finger 1 knockdown promotes osteoclastogenesis and bone loss in part by regulating RANKL-induced ferroptosis of osteoclasts through Nrf2/GPX4 signaling pathway.

The overactivation of the osteoclasts is a crucial pathological factor in the development of osteoporosis. MZF1, belonging to the scan-zinc finger family, plays a significant role in various processes associated with tumor malignant progression and acts as an essential transcription factor regulating osteoblast expression. However, the exact role of MZF1 in osteoclasts has not been determined.

Identification of Id1 in acquired middle ear cholesteatoma.

Objectives: To determine (1) the relationship between chronic inflammatory changes in the ossicular chain area (OCA) and the formation of cholesteatoma and (2) the correlates between aberrant gene expression and abnormal proliferation of cholesteatoma.

Methods: Two hundred sixty-four ears with chronic otitis media that had undergone ear surgery were included in this study for statistical analysis of the relationship between abnormalities in the OCA and cholesteatoma. Fourteen middle ear cholesteatoma specimens were collected for immunohistochemical analysis of candidate molecules involved in the abnormal proliferation of keratinocytes.

[Effects of quercetin on angiotensin II induced interleukin-6 in vascular smooth muscle cells].

Objective: To observe the effects of quercetin on angiotensin (Ang II) induced interleukin-6 (IL-6) in vascular smooth muscle cells (VSMCs).

Methods: VSMCs were isolated from the thoracic aorta of Sprague-Dawley rats and were stimulated with different doses of Ang II. The production of IL-6 in supernatant of quercetin treated cultures was detected by ELISA.