Factors based on Cox regression modeling to analyze the prognostic impact of fiberoptic bronchoscopic bronchoalveolar lavage on children with severe pneumonia.

Objective: This study aimed to identify factors influencing the prognosis of children with severe pneumonia (SP) after fiberoptic bronchoscopic bronchoalveolar lavage (BAL).

Methods: The clinical data of 155 children with SP treated with fiberoptic bronchoscopic BAL at Xi'an International Medical Center Hospital between January 2022 and January 2024 were retrospectively analyzed. Children were categorized into the survival group (n = 122) and the death group (n = 33) according to their clinical outcomes within 28 days after treatment.

Assessing the clinical utility of tumor invasion proportion of lymph nodes for enhanced risk stratification in N1 colorectal cancer.

N staging systems are paramount clinical features for colorectal cancer (CRC). In N1 stage (N1) CRC, patients present with a limited number of metastatic lymph nodes, yet their prognoses vary widely. The tumor invasion proportion of lymph nodes (TIPLN) has gained attention, but its prognostic value in N1 CRC remains unclear.

Moderate-intensity interval exercise exacerbates cardiac lipotoxicity in high-fat, high-calories diet-fed mice.

Physical exercise is a cornerstone for preventing diet-induced obesity, while it is unclear whether physical exercise could offset high-fat, high-calories diet (HFCD)-induced cardiac dysfunction. Here, mice were fed with HFCD and simultaneously subjected to physical exercise. As expected, physical exercise prevented HFCD-induced whole-body fat deposition.

Tumor burden with AFP improves survival prediction for TACE-treated patients with HCC: An international observational study.

Background & Aims: Current prognostic models for patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) are not extensively validated and widely accepted. We aimed to develop and validate a continuous model incorporating tumor burden and biology for individual survival prediction and risk stratification.

Methods: Overall, 4,377 treatment-naive candidates for whom TACE was recommended, from 39 centers in five countries, were enrolled and divided into training, internal validation, and two external validation datasets.

Uncovering the dynamics and causality of PTSD symptoms in firefighters: Insights from cross-lagged panel network analyses.

Firefighters have a greater prevalence of posttraumatic stress disorder (PTSD) because of their greater risk of exposure to traumatic events. Network analysis offers novel perspectives for understanding PTSD. However, most previous network analysis studies were cross-sectional and failed to reveal the dynamics and causality of PTSD symptoms.

A H2S-activated NIR-II imaging probe for precise diagnosis and pathological evaluation of colorectal tumor.

The quick and accurate detection of colorectal cancer (CRC) is essential for improving the treatment efficacy and patient survival, which nevertheless remains challenging due to low specificity and sensitivity of current CRC diagnostic approaches. Therefore, providing a robust solution for real-time and accurate tumor delineation is highly desirable. We report a novel polyacrylic acid-mediated strategy to develop the endogenous hydrogen sulfide (HS)-activated NIR-II probe DCNP@PB for specific visualization of CRC and image-guided tumor surgery.

Myelopathy as the first manifestation of AIDS.

Background: Human immunodeficiency virus (HIV) is a retrovirus mainly infecting immune cells. Central nervous system diseases in HIV-infected patients can be caused by HIV or opportunistic infections. Neurological diseases associated with HIV have diverse manifestations and may occur in early or late stages.

Association of D-dimer/fibrinogen ratio and combination of D-dimer and fibrinogen with prognosis of stroke and stroke subtypes.

Objective: Here, we aim to investigate whether D-dimer (DD)/fibrinogen (FIB) ratio or combination of DD and FIB contribute to the prognosis of stroke and stroke subtypes.

Methods: 1413 patients with acute ischemic stroke (AIS) were recruited. We measured DD and FIB levels on admission and followed up with patients at discharge and 90-day following discharge.

Development of a predictive model for immune‑related adverse events in patients with cancer.

It is crucial to accurately identify patients with cancer at high risk for immune-related adverse events (irAEs) caused by immune checkpoint inhibitors (ICIs). The present retrospective study analyzed the risk factors for irAEs in 992 patients with cancer treated with ICIs at Xi'an International Medical Center Hospital from December 2021 to December 2023. The patients were categorized into one group that experienced irAEs (n=276) and a control group (n=716) based on the occurrence of irAEs.

The incidence and risk factors of fetuses with mirror-image dextrocardia with solitus inversus.

Objective: This research seeks to ascertain the prevalence and determinants of mirror-image dextrocardia in fetuses.

Study Design: With December 2022 as the reference point, we compiled colleted data on pregnant women who carried fetuses with mirror-image dextrocardia in Xi'an, Shaanxi Province: September-October 2022, November 2022, and December 2022-January 2023. An online questionnaire was distributed to 209 pregnant across China who had contracted COVID-19.

Qiu's Cervical Prescription inhibit the invasion and growth of cervical cancer through LncRNA ATB/miR-126 pathway.

Background: Cervical cancer (CC) is one of the most deadly cancers in women, its current treatments still result in poor outcomes and developing the novel targets and therapeutic strategies are urgently needed. Qiu's Cervical Prescription (QCP) is one of the traditional Chinese medicines used in the treatment of cervical cancer in China. Although its curative effect is remarkable, the internal mechanism of its treatment is still poorly understood.

Surpass Streamline Flow Diverter for the Treatment of Craniocervical Unruptured Dissecting Aneurysms: A Multi-Institutional Retrospective Study.

Objective: Currently, there is no established treatment consensus for craniocervical unruptured dissecting aneurysms (UDAs). This study aimed to assess the safety and efficacy of the Surpass Streamline Flow Diverter (SSFD) for treating craniocervical UDAs.

Methods: A retrospective review of 3 centers' databases was conducted to identify patients with craniocervical UDAs treated with SSFDs from January 2021 to December 2023.

Lateral malleolus-first fixation improves short-term recovery in patients with trimalleolar fractures.

Objective: To evaluate the impact of different surgical fixation sequences on ankle joint stability and functional recovery in patients with trimalleolar fractures.

Methods: A retrospective analysis was conducted on the medical records of 144 patients with trimalleolar fractures treated at Xi'an International Medical Center Hospital. Among these, 78 patients underwent the fixation sequence of lateral malleolus-posterior malleolus-medial malleolus (Group A), while 66 patients underwent the sequence of posterior malleolus-lateral malleolus-medial malleolus (Group B).

Precision medicine: an intrahepatic cholangiocarcinoma with a novel RBPMS-MET fusion sensitive to crizotinib.

Background: Intrahepatic cholangiocarcinoma is a malignant tumor that starts from the epithelium of the bile duct and has a poor prognosis. They are characterized by poor response to chemotherapy and lack of effective targeted therapies; thus, therapeutic options are limited.

Case Presentation: A 59-year-old man was admitted to the hospital for a workup of abnormal CA19-9 levels.

Deletion of BRCC3 ameliorates airway inflammation in asthma by inhibiting the activation of NLRP3 inflammasome.

BRCA1/BRCA2-containing complex subunit 3 (BRCC3) serves as a deubiquitinating enzyme contributing to multiple inflammation-related disorders. However, the role of BRCC3 in modulating airway inflammation in asthma has not been investigated. This study aimed to examine the role of BRCC3 in airway inflammation using a mouse model of asthma induced by ovalbumin (OVA).

Glucagon-like Peptide 1 Receptor Agonists for the Treatment of Obstructive Sleep Apnea：a meta-analysis.

Study Objectives: Obstructive sleep apnea (OSA) is characterized by disordered breathing during sleep and is associated with major cardiovascular complications. Glucagon-like peptide 1 receptor agonists (GLP-1RA) as an important treatment for obesity and diabetes mellitus show promising therapeutic prospect in OSA. We conducted a meta-analysis to evaluate the effect of GLP-1RA intervention in OSA individuals.

A Novel Endoscopic Approach to Fibroadipose Vascular Anomaly.

Background: Open surgery is the standard treatment for fibroadipose vascular anomalies (FAVA). This study evaluated an endoscopic approach for FAVA, assessing its safety and feasibility.

Methods: Data from October 1, 2019, and May 1, 2024, were analyzed from the Vascular Anomalies Center database at our institution.

STC1 promotes esophageal squamous cell carcinoma progression and is associated with poor prognosis.

Background: Esophageal squamous cell carcinoma (ESCC) is a malignant tumor that poses a significant threat to human health. Patients are often diagnosed at advanced stages of the disease, resulting in poor clinical outcomes and a short survival period. Recent advances have revealed that ESCC tumors exhibit distinct molecular biological characteristics.

Association between ideal cardiovascular health and bowel conditions among US adults.

Objective: The aim of this study is to explore the relationship between ideal cardiovascular health (CVH), as assessed using the Life's Essential 8 (LE8), and bowel conditions.

Methods: This cross-sectional study selected 11,108 participants aged ≥20 years from 2005 to 2010 National Health and Nutrition Examination Survey. LE8 scores (range 0-100) were measured according to American Heart Association definitions and were divided into health behavior and health factor scores.