Early Diagnosis Value of DCE-MRI Hemodynamic Parameters in Hepatocellular Carcinoma.

Objective: To probe into the early diagnosis value of transfer coefficient ( ) and rate constant ( ) of the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) hemodynamic parameters in patients with hepatocellular carcinoma (HCC).

Methods: Fifty patients with HCC diagnosed in our hospital from May 2017 to May 2020 were studied retrospectively as the patient group (PG), and 45 cases with benign liver nodules diagnosed in our hospital during the same period were collected as the control group (CG). , , and AFP levels were compared between PG and CG.

Genome-wide DNA methylation analysis in renal ischemia reperfusion injury.

Renal ischemia reperfusion injury (IRI) is frequently encountered after kidney transplantation and is a leading cause of acute renal failure. Aberrant gene expression and epigenetic regulation occur during the pathophysiology of IRI. In this study, we used reduced representation bisulfite sequencing to identify the DNA methylome of renal tissues during IRI and the sham-operated tissues in C57BL/6.

Decreased functional connectivity to posterior cingulate cortex in major depressive disorder.

The default mode network (DMN) and its interaction with other key networks such as the salience network and executive network are keys to understand psychiatric and neurological disorders including major depressive disorder (MDD). In this study, we combined independent component analysis and seed based connectivity analysis to study the posterior default mode network between 20 patients with MDD and 25 normal controls, as well as pre-treatment and post-treatment conditions of the patients. Both correlated and anti-correlated networks centered at the posterior cingulate cortex (PCC) were examined (PCC+ and PCC-).

Hypothalamus-anchored resting brain network changes before and after sertraline treatment in major depression.

Sertraline, one of the oldest antidepressants, remains to be the most efficacious treatment for depression. However, major depression disorder (MDD) is characterized by altered emotion processing and deficits in cognitive control. In cognitive interference tasks, patients with MDD have shown excessive hypothalamus activity.