Simulation and experiment of leakage and diffusion of natural gas pipelines with different burial depths under different pressures.

In this paper, we studied the diffusion characteristics and distribution patterns of gas leakage in soil from buried natural gas pipelines. The three-dimensional simulation model of buried natural gas pipeline leakage was established using Fluent software. Monitoring points of gas leakage mole fraction were set up at different locations, and the influence of buried depth and pressure factors on the mole fraction and diffusion of leaked gas was analyzed.

Design of integrated radar and communication system based on solvable chaotic signal.

In the integrated radar and communication system (IRCS), the design of signal that can simultaneously satisfy the radar detection and communication transmission is very important and difficult. Recently, some new properties of a class of solvable chaotic system have been studied for wireless applications, such as low bit error rate (BER) wireless communications and low cost target detection. In this paper, a novel IRCS based on the chaotic signal is proposed, and the performance of proposed scheme is analyzed.

Cross sectional associations of physical activity and sleep with mental health among Chinese university students.

Objective: This study aimed to examine the levels of physical activity (PA), sleep, and mental health (MH), specifically depression, anxiety, and stress, among Chinese university students. It also aimed to analyze the influencing factors of MH, providing a theoretical foundation for developing intervention programs to improve college students' mental health.

Methods: A stratified, clustered, and phased sampling method was employed.

Triglyceride to high density lipoprotein cholesterol ratio and major adverse cardiovascular events in ACS patients undergoing PCI.

The triglyceride to high density lipoprotein cholesterol (TG/HDL-C) ratio has been consistently linked with the risk of coronary heart disease (CHD). Nevertheless, there is a paucity of studies focusing on acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) or experiencing bleeding events. The study encompassed 17,643 ACS participants who underwent PCI.

Analysis of bulletproof performance of structurally optimized ceramic composite armor through numerical simulation and live fire test.

This work aims to address key issues in the ballistic performance of ceramic-based composite armor, particularly at the joints of spliced ​​bulletproof panels. The edge structure of C/C-SiC ceramic plates and ultra-high molecular weight polyethylene is redesigned to superimpose the joint areas. These structurally optimized composite pads are examined by numerical simulation of impact dynamics to understand their anti-penetration performance whose accuracy is then validated by live fire tests.

SEAD reference panel with 22,134 haplotypes boosts rare variant imputation and genome-wide association analysis in Asian populations.

Limited whole genome sequencing (WGS) studies in Asian populations result in a lack of representative reference panels, thus hindering the discovery of ancestry-specific variants. Here, we present the South and East Asian reference Database (SEAD) panel ( https://imputationserver.westlake.

Identifying and tuning coordinated water molecules for efficient electrocatalytic water oxidation.

Coordination complexes are promising candidates for powerful electrocatalytic oxygen evolution reaction but challenges remain in favoring the kinetics behaviors through local coordination regulation. Herein, by refining the synergy of carboxylate anions and multiconjugated benzimidazole ligands, we tailor a series of well-defined and stable coordination complexes with three-dimensional supramolecular/coordinated structures. The coordinated water as potential open coordination sites can directly become intermediates, while the metal center easily achieves re-coordination with water molecules in the pores to resist lattice oxygen dissolution.

A coopetition-driven strategy of parallel/perpendicular aromatic stacking enabling metastable supramolecular polymerization.

Metastable supramolecular polymerization under kinetic control has recently been recognized as a closer way to biosystem than thermodynamic process. While impressive works on metastable supramolecular systems have been reported, the library of available non-covalent driving modes is still small and a simple yet versatile solution is highly desirable to design for easily regulating the energy landscapes of metastable aggregation. Herein, we propose a coopetition-driven metastability strategy for parallel/perpendicular aromatic stacking to construct metastable supramolecular polymers derived from a class of simple monomers consisting of lateral indoles and aromatic core.

Intensification of future subsurface marine heatwaves in an eddy-resolving model.

A shift in depth range enables marine organisms to adapt to marine heatwaves (MHWs). Subsurface MHWs could limit this pathway, yet their response to climate warming remains unclear. Here, using an eddy-resolving Earth system model forced under a high emission scenario, we project a robust global increase in subsurface MHWs driven by rising subsurface mean temperatures and enhanced temperature variability.

Mechanical Force-Induced cGAS Activation in Carcinoma Cells Facilitates Splenocytes into Liver to Drive Metastasis.

Liver metastasis is the main cause of cancer-related mortality. During the metastasis process, circulating carcinoma cells hardly pass through narrow capillaries, leading to nuclear deformation. However, the effects of nuclear deformation and its underlying mechanisms on metastasis need further study.

Association of D-dimer/fibrinogen ratio and combination of D-dimer and fibrinogen with prognosis of stroke and stroke subtypes.

Objective: Here, we aim to investigate whether D-dimer (DD)/fibrinogen (FIB) ratio or combination of DD and FIB contribute to the prognosis of stroke and stroke subtypes.

Methods: 1413 patients with acute ischemic stroke (AIS) were recruited. We measured DD and FIB levels on admission and followed up with patients at discharge and 90-day following discharge.

Toward Green Liquid Nitrogen Fertilizer Synthesis: Plasma-Driven Nitrogen Oxidation and Partial Electrocatalytic Reduction.

Liquid fertilizers, particularly when integrated with precision irrigation systems, offer a more efficient and sustainable alternative to traditional solid nitrogen fertilizers. The industrial production of ammonium nitrate (NHNO) is environmentally detrimental due to its reliance on fossil fuels. This study introduces an innovative air-to-NOx-to-NHNO pathway for synthesizing liquid nitrogen fertilizer.

Temperature-Robust Broadband Metamaterial Absorber via Semiconductor MOFs/Paraffin Hybridization.

The demand for temperature-robust electromagnetic wave (EMW) absorption materials is escalating due to the varying operational temperatures of electronic devices, which can easily soar up to 100 °C, significantly affecting EMW interference management. Traditional absorbers face performance degradation across broad temperature ranges due to alterations in electronic mobility and material impedance. This study presented a novel approach by integrating semiconductor metal-organic frameworks (SC-MOFs) with paraffin wax (PW), leveraging the precise control of interlayer spacing in SC-MOFs for electron mobility regulation and the introduction of paraffin wax for temperature-inert electromagnetic properties.

The Doping of Al3+ at the Tetrahedral Site of Spinel Mn3O4 for Electrocatalytic Water Oxidation.

Spinel oxides have attracted much attention in electrocatalytic water oxidation. Specially, the Mn-based spinel structures merits fundamental investigation, as Mn is involved in water oxidation in natural photosynthesis. Herein, Al-doped Mn3O4 spinel electrocatalyst was prepared for water oxidation.

The SUMO (Singly Unoccupied Molecular Orbital)-LUMO (Lowest Unoccupied Molecular Orbital) Inversion Radicals.

Herein, SUMO-LUMO inversion (SLI) radicals - were designed by the combination of the tris(2,4,6-trichlorophenyl)methyl (TTM) radical and pyridinium derivatives (electron-withdrawing groups) for the first time. The energy of the LUMO lies below that of the SUMO, which deviated from the Aufbau principle as an alternative electronic configuration beyond the well-established SOMO-HOMO inversed system. Thus, for SLI radicals, the injection of one extra electron preferred to occupy the LUMO rather than the SUMO, giving diradicals, one of which had been fully confirmed by single crystal analysis, VT-NMR and VT-EPR experiments, as well as DFT calculations.

Xixin Decoction May Treat VaD by Modulating the NPTX2/C1q/C3 Complement Pathway.

Vascular dementia (VaD) is a type of dementia that results from brain injury caused by cerebrovascular disease or vascular risk factors. Accumulating evidence from clinical studies has found that Xixin decoction can effectively improve the cognitive function of patients with VaD and improve their daily living ability. However, the pathogenesis of VaD is not fully understood, and the therapeutic mechanism of Xixin decoction is also unclear.

Status quo and influencing factors of job burnout among residents in standardized training.

Background: With the continuous progress and in-depth implementation of the reform of the medical and health care system, alongside the gradual enhancement of the standardized training framework for residents, such training has become a crucial avenue for cultivating high-level clinicians and improving medical quality. However, due to various constraints and limitations in their own capabilities, residents undergoing standardized training are often susceptible to job burnout during this process. Numerous factors contribute to job burnout, which is closely associated with depression and anxiety.

Echocardiography-guided percutaneous intramyocardial septal radiofrequency ablation procedure for the treatment of Fabry disease: a case report.

Background: This is a case report of a patient with Fabry disease (FD). We successfully treated a patient with ventricular septal hypertrophy and left ventricular outflow tract (LVOT) obstruction caused by FD. We report our exclusive new surgery for patients with LVOT obstruction, percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) procedure™ (percutaneous intramyocardial septal radiofrequency ablation).

Serum Globulin and Albumin-to-Globulin Ratio are Associated with Diabetic Kidney Disease but Not Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study.

Purpose: This study aimed to explore the association of globulin and albumin-to-globulin ratio (AGR) with diabetic kidney disease (DKD) and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM).

Methods: This study used data from the China National Diabetic Chronic Complications Study in Shaanxi Province. From April to May 2019, T2DM patients at disease surveillance sites in Shaanxi Province were investigated using a stratified multi-stage sampling method.

Development of a predictive model for immune‑related adverse events in patients with cancer.

It is crucial to accurately identify patients with cancer at high risk for immune-related adverse events (irAEs) caused by immune checkpoint inhibitors (ICIs). The present retrospective study analyzed the risk factors for irAEs in 992 patients with cancer treated with ICIs at Xi'an International Medical Center Hospital from December 2021 to December 2023. The patients were categorized into one group that experienced irAEs (n=276) and a control group (n=716) based on the occurrence of irAEs.

Association between meniscal extrusion and disease severity in knee osteoarthritis: a retrospective case-control study.

Objective: To explore the relationship between meniscus compression and the severity of knee osteoarthritis.

Materials And Methods: A retrospective case-control study included 95 patients with knee osteoarthritis (OA) admitted to our hospital from April 2021 to July 2023, who were grouped into slight protrusion of meniscus group (n = 48) and severe protrusion of meniscus group (n = 47) according to the degree of meniscal extrusion. Various parameters, including Kellgren/Lawrence classification, imaging findings, cartilage damage grading, physical function assessments, and correlation analyses, were used to evaluate the relationship between meniscal extrusion and disease progression.

Single-cell RNA sequencing identifies the expression of hemoglobin in chondrocyte cell subpopulations in osteoarthritis.

In recent years, chondrocytes have been found to contain hemoglobin, which might be an alternative strategy for adapting to the hypoxic environment, while the potential mechanisms of that is still unclear. Here, we report the expression characteristics and potential associated pathways of hemoglobin in chondrocytes using single-cell RNA sequencing (scRNA-seq). We downloaded data of normal people and patients with osteoarthritis (OA) from the Gene Expression Omnibus (GEO) database and cells are unbiased clustered based on gene expression pattern.

The neural mechanisms of emotional flexibility influenced by the emotional valence shift direction and preparation effect.

Emotional flexibility refers to an individual's ability to change emotional responses in constantly changing environments to adapt to different situations. This study aims to use the Emotional Switching Task (EST) paradigm, combined with Electroencephalogram (EEG) technology and behavioral experiments, to explore the impact of emotional valence shift directions and preparation effects on the switching cost of emotional flexibility. The results found that when individuals switch from positive emotional valence to positive emotional valence, the switching cost is smaller than other transition directions.