Epidemiology and Antimicrobial Resistance of Stenotrophomonas maltophilia in China, 2014-2021.

Introduction: Stenotrophomonas maltophilia is an opportunistic pathogen associated with various nosocomial infections and is known for its intrinsic multidrug resistance. This study aims to provide a comprehensive overview of the epidemiology and resistance patterns of S. maltophilia in China from 2014 to 2021.

Scaffolding and Heavy-Atom Effects of Metal Chains Enhanced Tunable Long Persistent Luminescence in Metal-Organic Frameworks.

Metal-organic frameworks (MOFs) with long persistent luminescence (LPL) have attracted extensive research attention due to their potential applications in information encryption, anticounterfeiting technology, and security logic. The strategic combinations of organic phosphor linkers and metal ions lead to tremendous frameworks, which could unveil many undiscovered properties of organics. Here, the synthesis and characterization of a three-dimensional MOF (Cd-MOF) is reported, which demonstrates enhanced blue photoluminescence and a phosphorescent lifetime of 124 ms as compared to the pristine linker (HL) under ambient conditions due to the scaffolding and heavy-atom effects of metal chains in the framework.

Construction of Nanohydroxyapatite/Poly(sodium lipoate)-Based Bioactive Hydrogels for Cranial Bone Regeneration.

Persistent oxidative stress following bone defects significantly impedes the repair of bone tissue. Designing an antioxidative hydrogel with a suitable mechanical strength can help alter the local microenvironment and promote bone defect healing. In this work, α-lipoic acid (LA), a natural antioxidant small molecule, was chemically cross-linked with lipoic acid-functionalized poly(ethylene glycol) (PEG, = 6k or 10k) in sodium bicarbonate solution, to prepare LA-PEG hydrogels (LP, = 6k or 10k).

Piezoresistive Sensor Based on Porous Sponge with Superhydrophobic and Flame Retardant Properties for Motion Monitoring and Fire Alarm.

Polyurethane sponge is frequently selected as a substrate material for constructing flexible compressible sensors due to its excellent resilience and compressibility. However, being highly hydrophilic and flammable, it not only narrows the range of use of the sensor but also poses a great potential threat to human safety. In this paper, a conductive flexible piezoresistive sensor (CHAP-PU) with superhydrophobicity and high flame retardancy was prepared by a simple dip-coating method using A-CNTs/HGM/ADP coatings deposited on the surface of a sponge skeleton and modified with polydimethylsiloxane.

Action Potential Firing Patterns Regulate Dopamine Release via Voltage-Sensitive Dopamine D2 Autoreceptors in Mouse Striatum In Vivo.

Dopamine (DA) in the striatum is vital for motor and cognitive behaviors. Midbrain dopaminergic neurons generate both tonic and phasic action potential (AP) firing patterns in behavior mice. Besides AP numbers, whether and how different AP firing patterns per se modulate DA release remain largely unknown.

The antiarthritic effect of CBR-470-1 in hypoxic environment is to increase the level of NOD-like receptor family pyrin domain containing 3 ubiquitination by decreasing phosphoglycerate kinase 1 activity.

Background: Hypoxia can affect the occurrence and development of inflammation in humans, but its effects on the disease progression of osteoarthritis (OA) remain unclear. Synovial macrophages play an essential role in the progression of arthritis. Specifically, the activation of the NOD-like receptor family pyrin domain containing 3 (NLRP3) in macrophages induces the secretion of a series of inflammatory factors, accelerating the progression of OA.

Potential of nanopore sequencing for tuberculosis diagnosis and drug resistance detection.

Objectives: This study evaluates the effectiveness of nanopore sequencing for accurate detection of Mycobacterium tuberculosis pathogens and drug resistance mutations in clinical specimens.

Methods: A retrospective analysis of 2,421 specimens from suspected tuberculosis patients admitted to Xi'an Chest Hospital from 2022 to 2023 was conducted, with 131 specimens undergoing via real-time, fluorescence-based quantitative Polymerase Chain Reaction (qPCR), simultaneous amplification and testing RNA (RNA), Mycobacterium culture, Mycobacterium smear, and nanopore sequencing. Employing clinical tuberculosis diagnoses as the gold standard, sensitivity, specificity, positive predictive value, negative predictive value, concordance rate, and Kappa coefficient were measured for the five detection techniques.

Development of a set of indicators for the quality of chronic pain management in Chinese community-dwelling older adults: a Delphi study.

Background: Standardized and systematic quality assessments of chronic pain management, particularly among older adult populations, are lacking in resource-limited community settings. A specific set of indicators to evaluate the quality of chronic pain management in this population has yet to be developed. Therefore, the present study constructed a set of indicators to assess the quality of chronic pain management in Chinese community-dwelling older adults, providing a standardized reference and guidance for community health centers to manage chronic pain in this population.

Fibroblast Growth Factor 21 Confers Protection Against Asthma Through Inhibition of NLRP3 Inflammasome Activation.

Fibroblast growth factor 21 (FGF21) modulates the inflammatory response in a range of pathological conditions. However, whether FGF21 modulates asthma remains unexplored. This study sought to investigate its function in asthma using an ovalbumin (OVA)-induced mouse model.

Perioperative Changes in Serum Transaminases Levels Predicts Long-Term Survival Following Liver Resection of Hepatocellular Carcinoma.

Background: We sought to define whether and how hepatic ischemia/reperfusion (I/R) as manifested by perioperative aspartate aminotransferase (AST) and alanine aminotransaminase (ALT) levels impact long-term outcomes after curative-intent resection of hepatocellular carcinoma (HCC).

Patients And Methods: Intrasplenic injection of HCC cells was used to establish a murine model of HCC recurrence with versus without I/R injury. Patients who underwent curative resection for HCC were identified from a multi-institutional derivative cohort (DC) and separate external validation (VC) cohort.

Correction method of Mohr-Coulomb strength criterion for rock based on freeze-thaw and residual effects.

Under confining pressure, rocks transition from brittle failure to plastic failure, and residual strength exists after complete failure. However, in the process of establishing rock damage constitutive models, the strength criteria used usually do not consider residual stress. In cold region engineering, the freeze-thaw effect caused by temperature changes should be considered in the constitutive model, and strength criteria should also be introduced.

Insights into adolescent sleep and mental health in rural area of Northwestern China.

Adolescents in affluent nations have experienced a decline in sleep duration, associated with adverse outcomes such as behavioral issues and health concerns. However, the connection between sleep and mental well-being during adolescence, particularly in developing regions like rural China, remains underexplored. A cross-sectional study of 18,516 adolescents in 124 junior high schools in Ningxia, China, utilized the strengths and difficulties questionnaire to assess mental health.

Enhancing active fire detection in Sentinel 2 imagery using GLCM texture features in random forest models.

The array of wildfire activities instigated by human endeavors has emerged as a significant source of atmospheric pollution, posing considerable risks to both public health and property safety. This study harnesses Sentinel-2 satellite data, employing a variety of methods including spectral index methods, thresholding, and the Random Forest (RF) model for active fire spot detection. The research encompasses a wide range of land cover types across various Chinese regions.

Modelling the compensatory and carry-over effects between physical activity and fruit-vegetable consumption in young adults.

Physical activity (PA) and fruit and vegetable consumption (FVC) are crucial factors jointly affecting young adults' physical and mental health. However, the psychosocial interactive mechanisms of these behaviors remain understudied. Using a two-wave prospective design over two months, this study investigated the psychological mechanisms underlying multiple health behavior change (MHBC) through a novel two-layer social-cognitive framework, the Compensatory Carry-Over Action Model (CCAM), among 322 Chinese college students (19.

A novel biomarker of COVI-19: MMP8 emerged by integrated bulk RNAseq and single-cell sequencing.

COVID-19 has been emerging as the most influential illness which has caused great costs to the heath of population and social economy. Sivelestat sodium (SS) is indicated as an effective cure for lung dysfunction, a characteristic symptom of COVID-19 infection, but its pharmacological target is still unclear. Therefore, a deep understanding of the pathological progression and molecular alteration is an urgent issue for settling the diagnosis and therapy problems of COVID-19.

Examining the impact of globalization and natural resources on environmental sustainability in G20 countries.

The G20 countries are responsible for around 75% of the world's greenhouse gas (GHG) emissions, including the use of natural resources. In this regard, the role of globalization in achieving environmental sustainability is a relatively new topic of concern. As a result, the present study considers how globalization and natural resources affect GHG emissions, as well as the roles that renewable energy consumption and urbanization play in the G20 countries between 1990 and 2020.

The dual role of calnexin on malignant progression and tumor microenvironment in glioma.

Glioma is the most common malignant brain tumor. Previous studies have reported that calnexin (CANX) is significantly up-regulated in a variety of malignant tumors, including glioma, but its biological function and mechanism in glioma is still unclear. In this study, differentially expressed proteins in 3 primary glioblastoma multiforme (GBM) tissues and 3 paracancer tissues were identified by liquid chromatography-tandem mass spectrometry-based proteomic and bioinformatic analysis.

Feature decoupling integrated domain generalization network for bearing fault diagnosis under unknown operating conditions.

In real engineering scenarios, the complex and variable operating conditions of mechanical equipment lead to distributional differences between the collected fault data and the training data. This distribution difference can lead to the failure of deep learning-based diagnostic models. Extracting generalized diagnostic knowledge from the source domain in scenarios where the target domain is not visible is the key to solving this problem.

Theoretical analysis of additional surrounding rock pressure in shallow buried bias tunnel.

The existing calculation method for the surrounding rock pressure of shallow buried bias tunnel fails to account for the impact of the progressive failure characteristics of the surrounding rock and slope creep, thereby neglecting the additional pressure arising from slope creep. Therefore, the progressive instability failure mode of the surrounding rock of shallow buried bias tunnel was obtained by numerical simulation. Based on this, the theoretical analysis model of the additional pressure of shallow buried bias tunnel was established, and the calculation formula of the additional pressure was derived.

Association of baseline thyroid stimulating hormone with in-hospital outcomes in patients with atrial fibrillation and coronary artery diseases.

Objective: Thyroid-stimulating hormone (TSH) is related to increased atrial fibrillation (AF) inducibility and plays an important role in a variety of cardiovascular diseases. However, the association of baseline TSH with in-hospital outcomes in patients with AF and coronary artery disease (CAD) is unknown. This study aimed to investigate the distribution of baseline TSH and its association with in-hospital outcomes (major adverse cardiovascular events [MACE], all-cause death, or heart failure [HF]) in AF patients combined with CAD.

Stress causes lipid droplet accumulation in chondrocytes by impairing microtubules.

Objective: Abnormal mechanical stress is intimately coupled with osteoarthritis (OA). Microtubules play a vital role in the regulation of mechanotransduction and intracellular transport. The purpose of the present study was to investigate the impact of stress-induced microtubule impairment on intracellular transport and lipid droplet (LD) accumulation in chondrocytes.

Proliferative behaviours of CD90-expressing chondrocytes under the control of the TSC1-mTOR/PTHrP-nuclear localization segment pathway.

Objective: Some cells in temporomandibular joint (TMJ) cartilage undergo proliferation in response to negative pressure, which can be induced in vivo by creating bilateral anterior elevation (BAE). TMJ cartilage harbours CD90-expressing cells, and CD90 expression increases under certain controlled conditions. The parathyroid hormone-related peptide (PTHrP) nuclear localization segment (NLS) promotes chondrocyte proliferation, and mammalian target of rapamycin (mTOR) signalling plays a regulatory role in promoting PTHrP transcription.

Pathological-microenvironment responsive injectable GelMA hydrogel with visualized biodegradation for pressure-assisted treatment of hypertrophic scars.

Intralesional injection of 5-fluorouracil for the clinical treatment of hypertrophic scars (HS) remains challenging due to its short half-life, as well as the absence of evidence-based dosage and frequency injection guidelines. Herein, we developed a matrix metalloproteinases (MMPs)/reactive oxygen species (ROS)-responsive injectable prodrug hydrogel (GFP) that exhibits sustained drug release and fluorescence imaging capability, aiming to facilitate the optimization of injection dosage and frequency in HS treatment. The GFP hydrogel comprises gelatin methacryloyl and pendant methacryloyl-decorated tetrapeptide (PPPK) with 5-fluorouracil acetic acid/rhodamine B at the N-terminus.

Robust and ultra-thin nanocellulose/MXene composite film and its performance in efficient electricity-generation and sensing.

The conversion of mechanical energy into electrical energy by triboelectric nanogenerators (TENG) has attracted attention in recent years, particularly in the field of wearable sensor. In this work, TEMPO-oxidized cellulose nanofibers (TOCNF) with carboxylate groups were compounded with MXene to serve as both the negative friction layer and the electrode in assembling a TENG with nylon. The synergistic effect between TOCNF and MXene was analyzed to disclose its influence on the performance of the as-prepared TENG.

Multiscale Analysis of CO Adsorption Mechanisms on Porous Carbon: An Investigation into the Impact of Intrinsic Defects and Pore Size.

Porous carbon adsorption represents a critical component of CCUS technologies, with microporous structures playing an essential role in CO capture. The preparation of porous carbon introduces intrinsic defects, making it essential to consider both pore size and these defects for a comprehensive understanding of the CO adsorption mechanism. This study investigates the mechanisms of CO adsorption influenced by intrinsic defects and pore size using multiscale methods, incorporating experimental validation, Grand Canonical Monte Carlo simulations, and Density Functional Theory simulations.