The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression.

The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capillaries, thereby promoting injury and kidney failure. Here we show that expression of the tetraspanin CD9 increases markedly in PECs in mouse models of CGN and FSGS, and in kidneys from individuals diagnosed with these diseases.

Osteomyelitis of the Mandible after Dental Implants in an Immunocompetent Patient.

Dental implants are now broadly used to replace missing teeth, and the presence of infectious complications is rising. Dental implant therapy as a local risk factor for the onset of osteomyelitis and its management have not been widely explored. Here, we report an unusual case of mandibular suppurative osteomyelitis caused by in a healthy and immunocompetent patient secondary to mandibular implants.

Magnetic resonance imaging of subacute myelopathy due to cobalamin deficiency.

A 77-year-old woman presented with rapidly ascending sensory ataxia. Magnetic resonance imaging (MRI) showed extensive involvement of the dorsal columns of the spinal cord. Hematological data were normal despite severe cobalamin deficiency.

Heterogeneous distribution of technetium-99m-labeled microspheres in rat lungs: microautoradiographic evidence and dosimetric consequences.

Unlabelled: The heterogeneity of 99mTc-labeled microspheres distribution within rat lung was visualized and quantified using a microautoradiographic "track" method (MAR).

Methods: MAR was used to study the uptake of radioactivity by individual microspheres, thereby enabling calculation of the range of particle activity. MAR was also used to visualize in rat lung sections the intrapulmonary distribution of the microspheres within the lungs after intravenous administration.

Anti-vascular endothelial cell antibodies (AECA): comparison of two assay methods and clinical applications.

Vascular endothelial cells may be a target for autoantibodies (AECAs) against membrane antigens that are constitutively expressed, induced or bound to their surface. To test this hypothesis, we used an enzyme-linked immunosorbent assay (ELISA) with two types of human endothelial cells as the substrate, i.e.