3 results match your criteria: "Wuxi Branch of Ruijin Hospital Shanghai Jiao Tong University School of Medicine[Affiliation]"
Diagnostic performance of adult-based thyroid imaging reporting and data systems in pediatric thyroid carcinoma: a retrospective study.
BMC Med Imaging
November 2024
Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Article Synopsis
- Pediatric thyroid nodules have a higher risk of cancer than adult nodules, yet there is no dedicated ultrasound evaluation system for children.
- This study analyzed ultrasound images of 177 thyroid lesions from kids under 18 to see how well adult-based systems (ACR-TIRADS and C-TIRADS) could identify cancer.
- Findings showed strong diagnostic ability and agreement for both systems, but they emphasized the need for a more tailored ultrasound evaluation specifically for children’s thyroid nodules.
Targeting PLCG2 Suppresses Tumor Progression, Orchestrates the Tumor Immune Microenvironment and Potentiates Immune Checkpoint Blockade Therapy for Colorectal Cancer.
Int J Biol Sci
November 2024
Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tumor progression and limited benefits of immune checkpoint blockade (ICB) therapy have been two major challenges in the clinical management of colorectal cancer (CRC). The objective of our research was to explore the role of PLCG2 in CRC progression, tumor microenvironment, and potentiating ICB therapy. Based on bioinformatics analysis and a prospective clinical observational study, the expression, prognostic significance, and clinical relevance of PLCG2 in CRC were unveiled.
View Article and Find Full Text PDFSystematic alanine and stapling mutational analysis of antimicrobial peptide Chem-KVL.
Bioorg Med Chem Lett
July 2024
Wuxi Branch of Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Wuxi 214000, China. Electronic address:
Article Synopsis
- Chem-KVL is a modified peptide derived from the human defense protein chemerin, designed to enhance antibacterial properties by increasing cationicity and hydrophobicity.
- Researchers created various versions of Chem-KVL peptides (Chem-A1 to Chem-A14 and SCL-1 to SCL-7) to analyze their antibacterial activity, proteolytic stability, and cytotoxicity through alanine and stapling scans.
- Key findings showed that specific charged and hydrophobic amino acids were essential for the peptide's effectiveness, with staples enhancing activity and stability, particularly in peptides SCL-4 and SCL-7, making them promising candidates for antimicrobial therapy.