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Article Synopsis
  • Surface-enhanced Raman scattering (SERS) technology faces reliability and reproducibility challenges in bio-related analysis, but Prussian blue (PB)-based SERS tags offer a potential solution due to their distinctive Raman band that allows for background-free detection.
  • The multi-layer structure of PB ensures stable signal output by preventing the desorption of Raman reporters, alongside possessing excellent multiplexing capabilities for analyzing multiple targets simultaneously.
  • This minireview emphasizes the current state and future prospects of PB-based SERS tags in various biological applications, including quantification, cell imaging, and their roles in clinical diagnosis and treatment.
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