Electrochemical radical-mediated selective C(sp)-S bond activation.

Selective C(sp)-S bond breaking and transformation remains a particularly important, yet challenging goal in synthetic chemistry. Over the past few decades, transition metal-catalyzed cross-coupling reactions through the cleavage of C(sp)-S bonds provided a powerful platform for the construction of target molecules. In contrast, the selective activation of widespread C(sp)-S bonds is rarely studied and remains underdeveloped, even under relatively harsh conditions.