A reversible photoelectrochemical microsensor for dynamically monitoring sulfur dioxide in the epileptic brain.

Epilepsy is considered one of the most prevalent neurological disorders, yet the precise mechanisms underlying its pathogenesis remain inadequately elucidated. Emerging evidence implicates endogenous sulfur dioxide (SO) in the brain as playing a significant role in epilepsy and associated neuronal apoptosis. Consequently, tracking the dynamic fluctuations in the levels of SO and its derivatives (SO/HSO) provides valuable insights into the molecular mechanisms underlying epilepsy, with potential implications for its diagnosis and therapeutic intervention.

A ratiometric photoelectrochemical microsensor based on a small-molecule organic semiconductor for reliable analysis.

Photoelectrochemical (PEC) sensing has been developing quickly in recent years, while its application is still in the infancy. The complexity of biological environments poses a high challenge to the specificity and reliability of PEC sensing. We herein proposed the concept of small-molecule organic semiconductor (SMOS)-based ratiometric PEC sensing making use of the structural flexibility as well as readily tunable energy band of SMOS.