ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner.

Pancreatic cancer is characterized by severe metabolic stress due to its prominent desmoplasia and poor vascularization. Integrin subunit alpha 3 (ITGA3) is a cell surface adhesion protein involved in tumor progression. However, the role of ITGA3 in pancreatic cancer progression, especially in metabolic reprogramming, remains largely unknown.

EIF4A3-Induced hsa_circ_0118578 Expression Enhances the Tumorigenesis of Papillary Thyroid Cancer.

Circular RNA (circRNA) plays a regulatory role in the malignancy of papillary thyroid cancer (PTC). However, the role of a novel circRNA, hsa_circ_0118578, in PTC is not yet fully understood. This report focuses on unveiling hsa_circ_0118578's effect on PTC cell malignancy and reveals its mechanism in PTC progression.

Strong self-association of chitosan microgels at interface mediated high stabilities in Pickering emulsion.

The spontaneous self-organization of naturally-occurring polysaccharide particles into a thick and robust gel network at interface in Pickering emulsion is challenging. Inspired by the phenomenon that chitosan microgels (CSMs) with a certain size could self-associate into a solidified gel phase upon freezing, here we tentatively used CSMs to construct a highly-stable Pickering emulsion. CSMs can form a stable Langmuir's layer at the water/oil interface through the network deformation and re-arrangement of dangling chains, while the subsequent negative polymer coating can avoid the bridging resulting from the cross-association for CSMs on different emulsion droplets upon freezing.

Immunometabolism in head and neck squamous cell carcinoma: Hope and challenge.

Immunotherapy has improved the survival rate of patients with head and neck squamous cell carcinoma (HNSCC), but less than 20 % of them have a durable response to these treatments. Excessive local recurrence and lymph node metastasis ultimately lead to death, making the 5-year survival rate of HNSCC still not optimistic. Cell metabolism has become a key determinant of the viability and function of cancer cells and immune cells.

Ni(0) formation on carbon felt cathode triggers redox synergetic degradation of Ni-EDTA during electrochemical treatment for Ni-plating wastewater.

Ni organic complexes are widely used in industrial production, posing severe threats to the natural environment and human health. In this work, we found that Ni (0) formed by the decomplexation and reduction of typical Ni organic complexes (Ni-EDTA) on the surface of carbon felt cathode. The formed Ni(0) as a catalytic site generates atomic hydrogen (H•) with strong reductive reactivity via electron transfer.

Effects of a Smartphone-Based Breastfeeding Coparenting Intervention Program on Breastfeeding-Related Outcomes in Couples During First Pregnancy: Randomized Controlled Trial.

Background: A low breastfeeding rate causes an increased health care burden and negative health outcomes for individuals and society. Coparenting is an essential tactic for encouraging breastfeeding when raising a child. The efficacy of the coparenting interventions in enhancing breastfeeding-related outcomes is controversial.

Time-Resolved Levodopa Cascade Polymerization Tuned by Bimetallic MOF Fluorescent Nanozyme and Boric Acid for Butyrylcholinesterase Activity Dual-Mode Assay.

A ratiometric fluorescence-photothermal dual-mode assay method is constructed for the detection of butyrylcholinesterase (BChE) activity based on time-resolved levodopa (L-DOPA) cascade polymerization. First, a newly designed bimetallic metal-organic framework (MOF), Eu/Co-DPA (DPA: pyridine-2,6-dicarboxylic acid), is screened out as a fluorescent nanozyme with high catalytic activity and superior luminescence properties. In the presence of boric acid (BA), L-DOPA forms BA-esterified L-DOPA, which is catalyzed by Eu/Co-DPA to form the oligomers with strong blue fluorescence.

An improved bacterial single-cell RNA-seq reveals biofilm heterogeneity.

In contrast to mammalian cells, bacterial cells lack mRNA polyadenylated tails, presenting a hurdle in isolating mRNA amidst the prevalent rRNA during single-cell RNA-seq. This study introduces a novel method, ribosomal RNA-derived cDNA depletion (RiboD), seamlessly integrated into the PETRI-seq technique, yielding RiboD-PETRI. This innovative approach offers a cost-effective, equipment-free, and high-throughput solution for bacterial single-cell RNA sequencing (scRNA-seq).

Prognostic Effect of Trigeminal Neuralgia Treated With Percutaneous Balloon Compression by Machine Learning-based Modeling of Radiomic Morphological Features.

Background: Trigeminal neuralgia (TN) is defined as spontaneous pain in the region of the trigeminal nerve that seriously affects a patient's quality of life. Percutaneous balloon compression of the trigeminal ganglion is a simple and reproducible surgical procedure that reduces the incidence of TN, but the postoperative outcome is poor in some patients, with it being ineffective or TN recurring.

Objectives: To establish a machine learning-based clinical imaging nomogram to predict the recurrence of trigeminal neuralgia in patients treated with percutaneous balloon compression.

Chromones Featuring a [6,6]-Spiroketal Moiety Produced by Coculture of the Endophytic Fungi and .

Under the guidance of HPLC-DAD analysis, ten new chromones featuring a rare [6,6]-spiroketal moiety, namely chaetovirexylariones A-J (-), together with two known congeners (-), were isolated from coculture of the endophytic fungi and , from the rhizome of the medicinal plant Roxb. Their structures were elucidated via a combination of NMR and HRESIMS data, and the absolute configurations of - were determined by the chemical conversion and single-crystal X-ray diffraction (Cu Kα) experiments, as well as the comparison of the experimental and calculated electronic circular dichroism (ECD) data. Compound is the first report as a racemate of this type of natural product.

Role of PI3K/AKT/MAOA in glucocorticoid-induced oxidative stress and associated premature senescence of the trabecular meshwork.

The oxidative stress-induced premature senescence of trabecular meshwork (TM) represents a pivotal risk factor for the development of glucocorticoid-induced glaucoma (GIG). This study aimed to elucidate the pathogenesis of TM senescence in GIG. MethodsIntraocular pressure (IOP), transmission electron microscopy and senescence-associated protein expression in TM were evaluated in GIG mice.

Exploring the role of geothermal energy consumption in achieving carbon neutrality and environmental sustainability.

While there is extensive research on the environmental impacts of renewable energy sources, a notable gap remains in understanding the specific environmental effects of geothermal energy. This knowledge shortfall is particularly critical for Indonesia, which holds the world's second-largest geothermal potential but has yet to effectively harness these valuable resources. This study aims to address this gap by providing a preliminary evaluation of the dynamic impact of geothermal energy consumption and various macroeconomic variables on carbon dioxide (CO) emissions in Indonesia from 1995 to 2020.

Multimodal integration to identify the invasion status of lung adenocarcinoma intraoperatively.

Evaluating the invasiveness of lung adenocarcinoma is crucial for determining the appropriate surgical strategy, impacting postoperative outcomes. This study developed a multimodality model combining radiomics, intraoperative frozen section (FS) pathology, and clinical indicators to predict invasion status. The study enrolled 1,424 patients from two hospitals, divided into multimodal training, radiology testing, and pathology testing cohorts.

Programmable Morphology-Adaptive Peptide Nanoassembly for Enhanced Catalytic Therapy.

Nanocatalytic therapy holds significant promise in cancer treatment by exploiting the high oxidative stress within tumor cells. However, efficiently delivering nanocatalytic agents to tumor tissues and maximizing their catalytic activity in situ remain critical challenges. Morphology-adaptive delivery systems, capable of adjusting their physical form in response to physiological conditions, offer unique spatiotemporal control for navigating complex biological environments like the tumor microenvironment.

Cascade-Activatable Nanoprodrug System Augments Sonochemotherapy of Bladder Cancer.

Sonochemotherapy (SCT) has emerged as a powerful modality for cancer treatment by triggering excessive production of reactive oxygen species (ROS) and controlled release of chemotherapeutic agents under ultrasound. However, achieving spatiotemporally controlled release of chemotherapeutic agents during ROS generation is still an enormous challenge. In this work, we developed a cascade-activated nanoprodrug () system that utilizes a reversible covalent Schiff base mixed with a hypoxia-activatable camptothecin (CPT) prodrug.

Fully Printable Manufacturing of Miniaturized, Highly Integrated, Flexible Evaporation-Driven Electricity Generator Arrays.

Harvesting sustainable clean energy from natural water evaporation holds great promise to provide continuous power for portable and wearable electronics. However, poor portability and complex fabrication processes hinder the low-cost and large-scale integration of flexible evaporation-driven electricity generators (FEEGs). Herein, a fully-printed flexible evaporation-driven generator (PFEEG) is developed.

Entropy Manipulation of SrTiO Perovskite for Enhanced Thermoelectric and Mechanical Properties.

Reducing the thermal conductivity while maintaining excellent electrical transport properties is crucial for enhancing the thermoelectric performance of SrTiO-based perovskites. Here, we successfully achieved this goal through precisely manipulating the configurational entropy. A series of CaNdSr BaTiO ( = 0, 0.

Association between plant-based dietary patterns and cognitive function in middle-aged and older residents of China.

Background: Plant-based diets may protect against cognitive impairment; however, observational data have not been consistent.

Objective: This study aimed to evaluate the association between plant-based dietary patterns and cognitive function.

Methods: The study recruited 937 participants who were asked to complete food frequency questionnaires to assess the quality of their plant-based diets using the overall plant-based diet index (PDI), the healthful PDI (hPDI), and the unhealthful PDI (uPDI).

Conformation pattern changes in R1-pS262 tau peptide induced endogenous tau aggregation, synaptic damage, and cognitive impairments.

Background: To date, the effect of tau phosphorylation at different amino acid sites on the conformation and function of tau is still unclear in Alzheimer's disease (AD). Protein fingerprinting, also known as the protein folding shape code (PFSC) method, is a protein structure prediction technique based on protein sequence, which can reveal proteins' most likely spatial conformation.

Objective: To investigate the effect of phosphorylation on tau protein conformation using PFSC technology and further analyze the differences in the effect of phosphorylation on tau aggregation at specific sites.

A New Heavy-Duty Bearing Degradation Evaluation Method with Multi-Domain Features.

Under heavy load conditions, bearings are subjected to non-uniform and frequently changing loads, which leads to randomness in the spatial distribution of bearing degradation characteristics. Aiming at the problem that the traditional degradation index cannot accurately reflect the degradation state of heavy-duty bearings in the whole life cycle, a new degradation evaluation method based on multi-domain features is proposed in this paper, which aims to capture the early degradation point of heavy-duty bearings and characterize their degradation trend. Firstly, the energy entropy feature is obtained by improving the wavelet packet decomposition, and the original multi-domain feature set is constructed by combining the time domain and frequency domain features.

Weak Fiber Bragg Grating Array-Based In Situ Flow and Defects Monitoring During the Vacuum-Assisted Resin Infusion Process.

Monitoring of real-time flow and defects in the vacuum-assisted resin infusion (VARI) process can provide important guidelines for full impregnation of dry reinforcement. A weak fiber Bragg grating array was employed to obtain quasi-distributed monitoring results in real-time. Sensitivity testing of different kinds of coated optical fiber sensors (OFs) was carried out first, and the polyacrylate-coated OF showed a greater wavelength-shift response than the polyimide-coated one.

Dual-Port Six-Band Rectenna with Enhanced Power Conversion Efficiency at Ultra-Low Input Power.

In this paper, a novel topology and method for designing a multi-band rectenna is proposed to improve its RF-DC efficiency. The rectifier achieves simultaneous rectification using both series and parallel configurations by connecting two branches to the respective terminals of the diode, directing the energy input from two ports to the anode and cathode of the diode. Six desired operating frequency bands are evenly distributed across these two branches, each of which is connected to antennas corresponding to their specific operating frequencies, serving as the receiving end of the system.