536 results match your criteria: "Wuhan Union Hospital[Affiliation]"

The coronavirus disease 2019 pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) seriously affected global public health security. Studies on vaccines, neutralizing antibodies (NAbs) and small molecule antiviral drugs are currently ongoing. In particular, NAbs have emerged as promising therapeutic agents due to their well‑defined mechanism, high specificity, superior safety profile, ease of large‑scale production and simultaneous application for both prevention and treatment of viral infection.

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Background: The global BOLERO-2 trial established the efficacy and safety of combination everolimus (EVE) and exemestane (EXE) in the treatment of estrogen receptor positive (ER +), HER2-, advanced breast cancer (ABC). BOLERO-5 investigated this combination in a Chinese population (NCT03312738).

Methods: BOLERO-5 is a randomized, double-blind, multicenter, placebo controlled, phase II trial comparing EVE (10 mg/day) or placebo (PBO) in combination with EXE (25 mg/day).

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Background: Gastric cancer is a frequent and lethal solid tumor that has a poor prognosis and treatment result. Reprogramming of nucleotide metabolism is a characteristic of cancer development and progression.

Methods: We used a variety of machine learning techniques to create a novel nucleotide metabolism-related index (NMRI) using gastric cancer sample data obtained from the TCGA and GEO databases.

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Inflammatory Granulomas, Accompanied by Mild Proliferation of Spinous Layer in Primary Hypertrophic Osteoarthropathy.

Indian J Pediatr

November 2024

Department of Pediatrics, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Wuhan City, 430022, Hubei Province, China.

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Article Synopsis
  • Tirzepatide is a new medication that targets type 2 diabetes and potential long-term weight management by activating specific receptors in the body.
  • A review of randomized controlled trials revealed significant weight loss in patients using tirzepatide weekly compared to a placebo, with doses leading to an average weight loss of over 11 kg in some cases.
  • The treatment not only reduced body weight but also improved body mass index and waist circumference, with a notable percentage of patients achieving substantial weight loss milestones.
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The management of periprosthetic joint infection (PJI) and surgical site infection (SSI) after joint arthroplasty poses a major challenge in orthopedic surgery. This Editorial provides an overview of the studies published in the special issue "Management of PJI/SSI after Joint Arthroplasty", summarizing the key findings from these studies, which cover a wide range of topics, including stringent preventive strategies, comprehensive diagnostic methods, and personalized treatment modalities. The authors concluded the editorial with their perspectives regarding the status quo of research in this field and future directions for research, such as the development of novel antibiotics, biofilm research, patient-specific risk factors, and the integration of technological advancements (such as machine learning and artificial intelligence) into clinical practice.

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Adipocyte secreted NRG4 ameliorates age-associated metabolic dysfunction.

Biochem Pharmacol

July 2024

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Clinical Research Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China. Electronic address:

With the progressive aging of society, there is an increasing prevalence of age-related diseases that pose a threat to the elderly's quality of life. Adipose tissue, a vital energy reservoir with endocrine functions, is one of the most vulnerable tissues in aging, which in turn influences systematic aging process, including metabolic dysfunction. However, the underlying mechanism is still poorly understood.

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Background: Career maturity is a crucial indicator of career preparedness and unpreparedness can cause the turnover of new nurses. Considerable empirical work demonstrates the potential associations between specialty identity, self-efficacy, study engagement, and career maturity. This study aimed to explore the mediation role of self-efficacy and study engagement on the relationships between specialty identity and career maturity among Chinese nursing students.

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Article Synopsis
  • Ixekizumab is a monoclonal antibody used to treat moderate-to-severe plaque psoriasis, showing positive results in terms of effectiveness and tolerance, but there's a lack of safety data specific to Chinese patients.
  • A real-world observational study followed 663 patients in China for adverse events while they received ixekizumab treatment over 12 weeks, evaluating various safety parameters.
  • The study found that about 33.8% of patients reported at least one adverse event related to the treatment, with injection site reactions, infections, and allergic reactions being the most common, and noted that female patients experienced a higher proportion of adverse events compared to males.
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Aims: This cohort study aimed to explore the effect of a one-day online continuing medical education (CME) on the improvement of physicians' knowledge and clinical practice on functional dyspepsia (FD).

Methods: Physicians were invited to participate in this CME via medical education applications. FD training videos made in advance were sent to participants via a weblink.

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Association of Ultraprocessed Food Consumption with Risk of Cardiovascular Disease Among Individuals with Type 2 Diabetes: Findings from the UK Biobank.

Mol Nutr Food Res

May 2024

Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Scope: Among patients with diabetes, who have modified nutritional behavior and a higher risk of cardiovascular disease (CVD), the influence of ultraprocessed foods (UPFs) on CVD remains unknown. The study aims to evaluate the association between UPF intake and the risk of CVD among individuals with type 2 diabetes (T2D) and further examine the potential biological pathways linking the association.

Methods And Results: This study includes 5405 participants with T2D who provided at least one 24-h dietary recall from the UK Biobank study.

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  • Lupus erythematosus (LE) is a group of autoimmune diseases that can affect the skin, and it's hard for AI to tell the different types apart.
  • Researchers created a new deep learning system to help doctors correctly identify these types of LE and other similar skin conditions using many images and data collected from multiple locations in China.
  • The new system significantly improved the accuracy of doctors in diagnosing LE, raising their success rate from about 67% to over 81%, showing how helpful AI can be in medicine.
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  • Cardiovascular disease (CVD) is now the leading cause of death among prostate cancer (PCa) patients, particularly impacting those receiving androgen deprivation therapy (ADT), highlighting an urgent need to assess CVD risk in newly diagnosed PCa patients in China.
  • The study analyzed clinical data from 4,253 newly diagnosed PCa patients across 34 centers in China, finding that 27% had both PCa and CVD, with a notable percentage experiencing multiple cardiovascular conditions.
  • Results indicate a significant portion of patients were diagnosed at advanced stages of PCa, and those undergoing ADT were at a greater risk for CVD compared to those not receiving this treatment.
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Background And Aim: Both intestinal symptoms and comorbidities exist in irritable bowel syndrome (IBS) patients and influence their quality of life (QOL). More research is needed to determine how these variables impact the QOL of IBS patients. This study aimed to determine which specific factors had a higher influence on QOL and to further compare the effects of intestinal symptoms and comorbidities on QOL.

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Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders.

Cell Rep

March 2024

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China; Institute for Metabolic Disease, Fengxian Central Hospital Affiliated to Southern Medical University, Shanghai 226001, China. Electronic address:

Iron overload is closely associated with metabolic dysfunction. However, the role of iron in the hypothalamus remains unclear. Here, we find that hypothalamic iron levels are increased, particularly in agouti-related peptide (AgRP)-expressing neurons in high-fat-diet-fed mice.

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4-PBA exerts brain-protective effects against sepsis-associated encephalopathy in a mouse model of sepsis.

Exp Neurol

May 2024

Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong university of science and technology, Wuhan 430000, China; Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong university of science and technology, Wuhan 430000, China. Electronic address:

Background: Neuroinflammation assumes a pivotal role in both the etiological underpinnings and the dynamic progression of sepsis-associated encephalopathy (SAE). The occurrence of cognitive deficits with SAE is associated with neuroinflammation. 4-phenyl butyrate (4-PBA) may control inflammation by inhibiting endoplasmic reticulum stress (ERS).

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Background: Cytochrome C oxidase assembly factor 6 (COA6) is significantly involved in the progression of cancer and is aberrantly expressed in disease. Nevertheless, the comprehensive analysis of COA6 using many omics techniques, and its impact on the prognosis and immunological microenvironment of cancer patients, remains unexplored.

Methods: We gathered data from 33 cancer cases and conducted a thorough analysis of abnormalities in COA6 gene expression.

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Glucocorticoids increase adiposity by stimulating Krüppel-like factor 9 expression in macrophages.

Nat Commun

February 2024

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Cellular Homeostasis and Disease, Tianjin Medical University, Tianjin, China.

Article Synopsis
  • Glucocorticoids (GCs) like dexamethasone are linked to obesity, but the exact mechanisms are unclear, and macrophages play a central role in this process.
  • The study reveals that the expression of Krüppel-like factor 9 (Klf9) in macrophages is significantly increased by GCs, leading to their deactivation and promoting obesity.
  • Knocking out Klf9 in macrophages prevents obesity from chronic GC treatment by blocking inflammatory and metabolic pathways, suggesting that targeting Klf9 could be a potential therapeutic strategy for managing GC-induced obesity.
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Fluvoxamine inhibits Th1 and Th17 polarization and function by repressing glycolysis to attenuate autoimmune progression in type 1 diabetes.

Mol Med

February 2024

The Center for Biomedical Research, Department of Respiratory and Critical Care Medicine, NHC Key Laboratory for Respiratory Diseases, Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.

Background: Fluvoxamine is one of the selective serotonin reuptake inhibitors (SSRIs) that are regarded as the first-line drugs to manage mental disorders. It has been also recognized with the potential to treat inflammatory diseases and viral infection. However, the effect of fluvoxamine on autoimmune diseases, particularly type 1 diabetes (T1D) and the related cellular and molecular mechanisms, are yet to be addressed.

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Introduction: Previous studies suggested that electrical impedance tomography (EIT) has the potential to guide positive end-expiratory pressure (PEEP) titration via quantifying the alveolar collapse and overdistension. The aim of this trial is to compare the effect of EIT-guided PEEP and acute respiratory distress syndrome (ARDS) network low PEEP/fraction of inspired oxygen (FiO) table strategy on mortality and other clinical outcomes in patients with ARDS.

Methods: This is a parallel, two-arm, multicentre, randomised, controlled trial, conducted in China.

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Background: Hepatocellular carcinoma is one of the most common malignancies, and its prognosis and treatment outcome cannot be accurately predicted. ADP-ribosylation (ADPR) is a post-translationa modification of proteins involved in protein trafficking and immune response. Therefore, it is necessary to explore the ADPR-related genes associated with the prognosis and therapeutic efficacy of hepatocellular carcinoma treatments.

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An oxidized dextran-composite self-healing coated magnesium scaffold reduces apoptosis to induce bone regeneration.

Carbohydr Polym

March 2024

Department of Orthopedics, Ningbo No. 2 Hospital, Ningbo 315000, China; Health Science Center, Ningbo University, Ningbo 315211, China. Electronic address:

Article Synopsis
  • Self-healing coatings are being developed to prevent degradation and detachment issues in magnesium (Mg) scaffolds used in medical applications, especially in infection-prone areas.* -
  • The researchers created a specific self-healing coating, named OD-MHA/Mg, using oxidized dextran, APTES, and nano-hydroxyapatite, which effectively prevents coating issues and controls Mg degradation.* -
  • This innovative coating not only offers antibacterial and antioxidant properties but also supports bone repair by enhancing gene expression related to osteogenesis, making it a promising solution for treating infectious bone defects.*
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Background: Typical chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm caused by t(9; 22)(q34; q11) translocation. This chromosomal translocation forms the BCR::ABL1 fusion gene. The tyrosine kinase encoded by the BCR::ABL1 is considered to be the main pathogenic diver.

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