1 results match your criteria: "Wuhan Institute of Physics and Mathematics-Wuhan National Laboratory for Optoelectronics[Affiliation]"
Free-base porphyrins as CEST MRI contrast agents with highly upfield shifted labile protons.
Magn Reson Med
August 2019
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Collaborative Innovation Center of Chemistry for Life Sciences, Wuhan Institute of Physics and Mathematics-Wuhan National Laboratory for Optoelectronics, Chinese Academy of Sciences, Wuhan, People's Republic of China.
Purpose: CEST has become a preeminent technology for the rapid detection and grading of tumors, securing its widespread use in both laboratory and clinical research. However, many existing CEST MRI agents exhibit a sensitivity limitation due to small chemical shifts between their exchangeable protons and water. We propose a new group of CEST MRI agents, free-base porphyrins and chlorin, with large exchangeable proton chemical shifts from water for enhanced detection.
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