Discontinuity-Induced Dynamics in the Conductance-Based Adaptive Exponential Integrate-and-Fire Model.

In this article, we present a computational study of the Conductance-Based Adaptive Exponential (CAdEx) integrate-and-fire neuronal model, focusing on its multiple timescale nature, and on how it shapes its main dynamical regimes. In particular, we show that the spiking and so-called delayed bursting regimes of the model are triggered by discontinuity-induced bifurcations that are directly related to the multiple-timescale aspect of the model, and are mediated by canard solutions. By means of a numerical bifurcation analysis of the model, using the software package COCO, we can precisely describe the mechanisms behind these dynamical scenarios.

On the Design of the Metal-Support Interface in Methanol Electrocatalytic Oxidation.

In this work, we present a theoretical investigation of the SrTiO perovskite-supported Pd catalyst in the methanol electro-oxidation reaction. In order to determine the metal-support interactions, we designed a system consisting of a Pd (100) double layer supported on one of the two possible terminations of the (100) perovskite surface. These terminations are characterized by different reducibilities of the layers directly interacting with the Pd bilayer and result in the difference in the stability of the surface-bound intermediates.

Active piezoelectric bone conduction implant Osia 2 - evaluation of surgery and one-year audiological and quality of life benefits.

Purpose: To present the surgical outcomes and one-year audiological and quality of life results of implantation of the Osia2 active piezoelectric bone conduction implant.

Methods: Twenty adults with mixed and conductive hearing loss were implanted with the Osia 2 system and followed up for at least one year. The surgical course, healing, and soft tissue condition were assessed.

Neutrophil Elastase, Neuron-Specific Enolase, and S100B Protein as Potential Markers of Long-Term Complications Caused by COVID-19 in Patients with Type 2 Diabetes Mellitus (T2DM) and Advanced Stage of Diabetic Nephropathy (NfT2DM)-Observational Studies.

Despite numerous studies conducted by various research teams, predicting long-term outcomes (known as Post-COVID-19 Syndrome, PCS) that may result from Coronavirus Disease 2019 (COVID-19) remains challenging. PCS affects over a million people, primarily those with comorbid conditions. Therefore, it is crucial to undertake research aimed at developing a predictive model for early diagnosis of PCS, which in turn would enable faster preventive actions.

A Flexible Phosphonate Metal-Organic Framework for Enhanced Cooperative Ammonia Capture.

Ammonia (NH) production in 2023 reached 150 million tons and is associated with potential concomitant production of up to 500 million tons of CO each year. Efforts to produce green NH are compromised since it is difficult to separate using conventional condensation chillers, but in situ separation with minimal cooling is challenging. While metal-organic framework materials offer some potential, they are often unstable and decompose in the presence of caustic and corrosive NH.

From historical drugs to present perils: UHPLC-QqQ-MS/MS determination of methaqualone and its designer analogs (NPS) with comprehensive fragmentation pathways study (QTOF).

Methaqualone, introduced in the 1960s as a sedative-hypnotic alternative to barbiturates, was withdrawn from the market due to its side effects and growing recreational use. Despite this, interest in methaqualone and its analogs remains high, raising concerns about potential abuse in the future. An ultra-high-performance liquid chromatography method coupled with triple quadrupole tandem mass spectrometry (UHPLC-QqQ-MS/MS) was developed to determine nine methaqualone-related compounds simultaneously.

Goodness-of-fit tests for the one-sided Lévy distribution based on quantile conditional moments.

In this paper we introduce a novel statistical framework based on the first two quantile conditional moments that facilitates effective goodness-of-fit testing for one-sided Lévy distributions. The scale-ratio framework introduced in this paper extends our previous results in which we have shown how to extract unique distribution features using conditional variance ratio for the generic class of -stable distributions. We show that the conditional moment-based goodness-of-fit statistics are a good alternative to other methods introduced in the literature tailored to the one-sided Lévy distributions.

Hyperthermia and biological investigation of a novel magnetic nanobiocomposite based on acacia gum-silk fibroin hydrogel embedded with poly vinyl alcohol.

The design and synthesis of biocompatible nanostructures for biomedical applications are considered vital challenges. Herein, a nanobiocomposite based on acacia hydrogel, natural silk fibroin protein, and synthetic protein fibers of polyvinyl alcohol was fabricated and magnetized with iron oxide nanoparticles (FeO MNPs). The structural properties of the hybrid nanobiocomposite were investigated by essential analyses such as Fourier Transform Infrared Spectrometer (FTIR), Field emission scanning electron microscopy (FE-SEM), and X-ray powder diffraction)XRD(analyses, Thermogravimetric and Differential thermogravimetric analysis (TGA-DTG), Vibrating-sample magnetometry (VSM), and Energy Dispersive X-Ray Analysis (EDX).

Rethinking Assumptions: Assessing the Impact of Strong Magnetic Fields on Luminescence Thermometry.

Luminescence (nano)thermometry has exploded in popularity, offering a remote detection way to measure temperature across diverse fields like nanomedicine, microelectronics, catalysis, and plasmonics. A key advantage is its supposed immunity to strong electromagnetic fields, a crucial feature in many environments. However, this assumption lacks comprehensive experimental verification as most of the proposed luminescent thermometers rely on magnetic ions, such as lanthanides.

On the study of solitary wave dynamics and interaction phenomena in the ultrasound imaging modelled by the fractional nonlinear system.

This research work focuses on investigating the propagation of ultrasonic waves, which propagate mechanical vibrations of molecules or particles inside materials. Ultrasound imaging is extensively used and deeply rooted in the medical field. The key technologies that form the basis for many different uses in the area include transducers, contrast agents, pulse compression, beam shaping, tissue harmonic imaging, techniques for measuring blood flow and tissue motion, and three-dimensional imaging.

Heart Rate Variability and Cerebral Autoregulation in Patients with Traumatic Brain Injury with Paroxysmal Sympathetic Hyperactivity Syndrome.

Background: Severe traumatic brain injury (TBI) can lead to transient changes in autonomic nervous system (ANS) functioning and development of paroxysmal sympathetic hyperactivity (PSH) syndrome. Clinical manifestation of ANS disorders may be obscured by therapeutic interventions in TBI. This study aims to analyze ANS metrics and cerebral autoregulation in patients with PSH syndrome to determine their significance in early prognostication.

Theoretical insight into photodeactivation mechanisms of adenine-uracil and adenine-thymine nucleobase pairs.

In this work, several plausible intra- and intermolecular photoinduced processes of the Watson-Crick base pairs of adenine with uracil (A-U) or thymine (A-T) according to the results of spin component scaling variant of algebraic diagrammatic construction up to the second order [SCS-ADC(2)] calculations are discussed. Although widely explored, these systems lack complete characterization of possible intramolecular relaxation channels perturbed by intermolecular interactions. In particular, we address the still open debate on photodeactivation purine-ring puckering at the C2 or C6-atom position of adenine.

Subinhibitory concentrations of antibiotics affect development and parameters of biofilm.

Introduction: causes chronic gastric diseases in nearly 50% of people around the world. It is suggested that biofilm formation has a pronounced effect on the dynamic resistance spread and recurrence of these infections.

Methods: To mimic the scenario of therapeutic ineffectiveness, we investigated the impact of sub-minimal inhibitory concentrations (sub-MICs) of antibiotics on the development and parameters of biofilms produced by clinical strains.

High-Resolution Phase-Based Ranging Using Inverse Fourier Transform in an Iterative Bayesian Approach.

This article proposes an algorithm that determines the distance between two transceivers based on phase information collected in a specific frequency range. Even though we have focused on BLE technology, we do not necessarily adhere strictly to this standard regarding the procedures used to obtain phased samples. We assume that phase samples are given and propose an algorithm using a Bayesian approach to find delays in a multi-path environment.

Development of a Quality Control System Using Modal Analysis to Evaluate a Multi-Point Projection Welding Process.

The article presents the results of the development and research regarding the application of modal analysis to the evaluation of a multi-point projection welding process. The quality control system is based on the information provided by modal analysis for the entire welding station after the previously completed welding process. The research is carried out due to the lack of an effective method for assessing the course of the multi-spot projection welding process in the case of a single current circuit passing through many points at the same time.

Usefulness of the CHADS-VASc Score in Predicting the Outcome in Subjects Hospitalized with COVID-19-A Subanalysis of the COLOS Study.

Background: The aim of this study was to see if the CHADS-VASc score (Cardiac failure or dysfunction, Hypertension, Age ≥ 75 [Doubled], Diabetes, Stroke [Doubled]-Vascular disease, Age 65-74 and Sex category [Female] score) could have potential clinical relevance in predicting the outcome of hospitalization time, need for ICU hospitalization, survival time, in-hospital mortality, and mortality at 3 and 6 months after discharge home.

Materials: A retrospective analysis of 2183 patients with COVID-19 hospitalized at the COVID-19 Centre of the University Hospital in Wrocław, Poland, between February 2020 and June 2021, was performed. All medical records were collected as part of the COronavirus in LOwer Silesia-the COLOS registry project.

Renal Allograft Function and the Tacrolimus C/D Ratio: Insights from a Prospective Study on MeltDose Tacrolimus.

: The tacrolimus concentration-to-dose (C/D) ratio is valuable for optimizing nephrotoxicity-related renal outcomes. Prospective data on the C/D ratio in kidney transplant recipients newly treated with MeltDose tacrolimus are limited. We analyzed the C/D ratio pattern of MeltDose tacrolimus and its effect on posttransplant renal function, comparing it with the literature data on immediate-release tacrolimus (IR-Tac).

His Bundle Pacing and Left Bundle Branch Pacing in Patients with Heart Failure.

Background: His bundle pacing (HBP) and left bundle branch pacing (LBBP) are emerging therapies for patients with heart failure and conduction disorders, offering potential advantages over traditional pacing methods. These approaches aim to restore physiological conduction and improve cardiac function more effectively.

Objective: This study aims to evaluate the efficacy and safety of HBP and LBBP in patients with heart failure and conduction disturbances, comparing these techniques to conventional pacing.