The effect of hydrophilic base on pharmaceutical availability of prednisolone complexed with beta-cyclodextrin.

Studies on the effect of hydrophilic gel composition on pharmaceutical availability of prednisolone complexed with beta-cyklodextrin at P:beta-CD ratios 1:1 and 1:2 revealed that the half-release times were shortened and differentiated depending on the substances added hydrogel to propylene glycol, dimethylacetamide and polysorbate 20 in comparison to preparations containing non-complexed active substance.