Cardiomyocyte Reduction of Hybrid/Complex N-Glycosylation in the Adult Causes Heart Failure With Reduced Ejection Fraction in the Absence of Cellular Remodeling.

Background: Heart failure (HF) presents a massive burden to health care with a complex pathophysiology that results in HF with reduced left ventricle ejection fraction (EF) or HF with preserved EF. It has been shown that relatively modest changes in protein glycosylation, an essential posttranslational modification, are associated with clinical presentations of HF. We and others previously showed that such aberrant protein glycosylation in animal models can lead to HF.

Low-Intensity Vibration Protects the Weight-Bearing Skeleton and Suppresses Fracture Incidence in Boys With Duchenne Muscular Dystrophy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

The ability of low-intensity vibration (LIV) to combat skeletal decline in Duchenne Muscular Dystrophy (DMD) was evaluated in a randomized controlled trial. Twenty DMD boys were enrolled, all ambulant and treated with glucocorticoids (mean age 7.6, height-adjusted -scores [HAZ] of hip bone mineral density [BMD] -2.

Does this patient have jugular venous distension? Vein finder-enhanced assessment of jugular venous pressure.

Assessing jugular venous pressure (JVP) may be challenging yet useful for establishing the bedside diagnosis of congestive heart failure. Vein finder lights illuminate superficial veins and thus can improve visualization of the external jugular vein.

Old divergence and restricted gene flow between torrent duck () subspecies in the Central and Southern Andes.

Aim: To investigate the structure and rate of gene flow among populations of habitat-specialized species to understand the ecological and evolutionary processes underpinning their population dynamics and historical demography, including speciation and extinction.

Location: Peruvian and Argentine Andes.

Taxon: Two subspecies of torrent duck ().