Promoting Classroom Climate and Why it Matters in Anti-Hate Speech Prevention Programs: A HateLess Evaluation Study.

Inclusive and supportive classroom environments are essential, particularly during political and societal crises such as wars, disinformation, polarization, and rising populism and extremism. While existing research underscores the importance of such environments, few studies comprehensively examine the impact of anti-hate speech prevention programs on classroom dynamics and students' social development. This study addressed this gap by investigating the direct and indirect effects of the HateLess anti-hate speech prevention program on inclusive classroom climate, classroom cohesion, empathy, and self-efficacy among adolescents.

Ultrastructural characteristics of leishmania (L.)tropica (Wright, 1903) and cell-parasite relationships in cutaneous leishmaniasis. Light and electron microscopic study.

A light and electron microscopic study of skin biopsies taken from 9 patients with ulcerative leishmaniasis of both sexes aged from 14 to 26 years in the territory of the Republic of Azerbaijan was carried out. Based on clinical, morphological and electron microscopic parameters, all patients were diagnosed with ulcerative cutaneous anthroponotic leishmaniasis (Leishmania (L.) tropica).

Willingness to Use Oral and Long-Acting Injectable PrEP in Substance-Using Men who have Sex with Men (SU-MSM) in High HIV Incidence Southern U.S. Cities: A NIDA Clinical Trials Network Study.

In Southern U.S. states with high HIV incidence and low HIV Pre-Exposure Prophylaxis (PrEP) uptake, enhanced efforts to increase interest in and willingness to use PrEP are needed.

Design of an equilibrative nucleoside transporter subtype 1 inhibitor for pain relief.

The current opioid crisis urgently calls for developing non-addictive pain medications. Progress has been slow, highlighting the need to uncover targets with unique mechanisms of action. Extracellular adenosine alleviates pain by activating the adenosine A1 receptor (A1R).

Teaching Preclinical Medical Students Lifestyle Counseling Skills for Patients' Health Behavior Change.

Introduction: Physicians face barriers to counseling patients regarding lifestyle, specifically, low perceived importance of and confidence in counseling, leading to underuse. There is a dearth in the literature evaluating educational interventions for counseling skills among preclinical medical students. Closing this gap is crucial to taking advantage of critical opportunities early in training.

The moderating effect of parental mediation in the longitudinal associations among cyberbullying, depression, and self-harm among Chinese and American adolescents.

Researchers have concentrated on identifying factors that might mitigate the negative consequences associated with cyber victimization. One key factor that has garnered significant attention is parental mediation in adolescents' digital technology usage and its role in reducing the risk of cyber victimization. Additionally, the buffering effects of parental mediation on the longitudinal associations among cyberbullying victimization, depression, and self-harm have been underexplored, especially cross-cultural investigations of such effects.

A descriptive examination of rurality in the Environmental influences on Child Health Outcomes Cohort: Implications, illustrations, and future directions.

Purpose: The Environmental influences on Child Health Outcomes (ECHO) Cohort has enrolled over 60,000 children to examine how early environmental factors (broadly defined) are associated with key child health outcomes. The ECHO Cohort may be well-positioned to contribute to our understanding of rural environments and contexts, which has implications for rural health disparities research. The present study examined the outcome of child obesity to not only illustrate the suitability of ECHO Cohort data for these purposes but also determine how various definitions of rural and urban populations impact the presentation of findings and their interpretation.

Memristive Ion Dynamics to Enable Biorealistic Computing.

Conventional artificial intelligence (AI) systems are facing bottlenecks due to the fundamental mismatches between AI models, which rely on parallel, in-memory, and dynamic computation, and traditional transistors, which have been designed and optimized for sequential logic operations. This calls for the development of novel computing units beyond transistors. Inspired by the high efficiency and adaptability of biological neural networks, computing systems mimicking the capabilities of biological structures are gaining more attention.

Shifts in naturalistic behaviors induced by early social isolation stress are associated with adult binge-like eating in female rats.

Binge eating (BE) is a highly pervasive maladaptive coping strategy in response to severe early life stress such as emotional and social neglect. BE is described as repeated episodes of uncontrolled eating and is tightly linked with comorbid mental health concerns. Despite social stressors occurring at a young age, the onset of BE typically does not occur until adulthood providing an interval for potential therapeutic intervention.

'You want to shield your kids': Patients' and their adult-children's serious illness conversations.

Context: Timely and transparent serious illness conversations (SIC) between family caregivers and patients facilitate high-quality end-of-life care and patients' and family caregivers' mental wellbeing, but frequently do not occur, happen too late, or are incomplete. While social relations and roles shape communication, few studies explore their influence on patient-caregiver SICs.

Objectives: Investigate how the parent-child relation and roles shape SICs between cancer patients and their adult-child caregivers (ACC), the largest caregiver population.

Preserving and expanding the pipelines of surgeons.

Presidential address delivered at the 2024 Annual meeting of the Midwest Surgical Association, Mackinac Island, MI on August 6th 2024.

From classroom to community: A college of pharmacy's faculty and student participation at a harm reduction coalition.

Background And Purpose: Harm reduction is a paradigm that promotes safer drug consumption to maximize individuals' overall wellbeing. Equipping pharmacy faculty and students to engage in harm reduction can play a key role in addressing substance use disorders and facilitating meaningful educational experiences.

Educational Activity And Setting: Within the context of a 5-week ambulatory care advanced pharmacy practice experience (APPE), an APPE faculty preceptor and students engaged a harm reduction coalition with two primary objectives: street outreach initiatives and packaging of safer drug using kits.

Extending the Environmental influences on Child Health Outcomes (ECHO) Cohort through 2030: Rationale and study protocol.

Early life environmental exposures, even those experienced before conception, can shape health and disease trajectories across the lifespan. Optimizing the detection of the constellation of exposure effects on a broad range of child health outcomes across development requires considerable sample size, transdisciplinary expertise, and developmentally sensitive and dimensional measurement. To address this, the National Institutes of Health (NIH) Environmental influences on Child Health Outcomes (ECHO) Cohort Study is an observational longitudinal pediatric cohort study.

Lessons for Theory from Scientific Domains Where Evidence is Sparse or Indirect.

In many scientific fields, sparseness and indirectness of empirical evidence pose fundamental challenges to theory development. Theories of the evolution of human cognition provide a guiding example, where the targets of study are evolutionary processes that occurred in the ancestors of present-day humans. In many cases, the evidence is both very sparse and very indirect (e.

Mechanistic Analysis of Peptide Affinity to Single-Walled Carbon Nanotubes and Volatile Organic Compounds Using Chemiresistors.

Peptides, due to their diverse and controllable properties, are used as both liquid and gas phase recognition elements for both biological and chemical targets. While it is well understood how binding of a peptide to a biomolecule can be converted into a sensing event, there is not the same mechanistic level of understanding with regard to how peptides modulate the selectivity of semiconductor/conductor-based gas sensors. Notably, a rational, mechanistic study has not yet been performed to correlate peptide properties to the sensor response for volatile organic compounds (VOCs) as a function of chemical properties.

The "Mammograms Available Due to Resources and Education" (MADRE) Study: Rationale and Design.

Background: Latinas suffer disproportionately from breast cancer, partially due to lower uptake of guideline-concordant breast cancer screening. We describe the design of a study to compare two approaches addressing this important public health problem.

Design/methods: We are conducting a 5-year randomized controlled trial.

Does cognitive intra-individual variability predict change in everyday functioning performance in women with and without HIV in the Women's Interagency HIV Study?

This study examined the association between cognitive intra-individual variability (IIV), a non-mean-based indicator of underlying neuropathology, and self-reported everyday functioning of 1,086 women with HIV (WWH) and 494 socio-demographically similar women without HIV (WWoH). Objective cognitive performance across seven domains and the self-rated Lawton & Brody scale of Instrumental Activities of Daily Living (IADL) were assessed among participants of the Women's Interagency HIV Study. Two types of cognitive IIV were calculated by taking the standard deviation across seven cognitive domains to calculate dispersion: 1) intra-individual standard deviation (denoted as IIV) and 2) coefficient of variation (denoted as IIV).

Anticancer Effects of Arsenic Compounds in Non-Small Cell Lung Cancer.

Non-small cell lung cancer (NSCLC) is the most common and prevalent subtype of lung cancer and continues to be one of the leading causes of cancer-related deaths worldwide. Despite various treatment options, a majority of NSCLC patients continue to experience disease progression and associated side effects, which are largely attributed to drug resistance, indicating the need for alternative strategies to combat this deadly disease. Among various applicable alternative approaches, repurposed drugs such as arsenic compounds have been shown to exert anticarcinogenic properties against NSCLC and possess the ability to overcome drug resistance mechanisms.

Central mechanisms of muscle tone regulation: implications for pain and performance.

Muscle tone represents a foundational property of the motor system with the potential to impact musculoskeletal pain and motor performance. Muscle tone is involuntary, dynamically adaptive, interconnected across the body, sensitive to postural demands, and distinct from voluntary control. Research has historically focused on pathological tone, peripheral regulation, and contributions from passive tissues, without consideration of the neural regulation of active tone and its consequences, particularly for neurologically healthy individuals.

Extended Reality Gaming for Exercise and Mindfulness Throughout Pediatric Cancer Rehabilitation: Protocol for a Randomized Controlled Trial.

Background: Pediatric patients with cancer have limited options to self-manage their health while they are undergoing treatments in the hospital and after they are discharged to their homes. Extended reality (ER) using head-mounted displays has emerged as an immersive method of improving pain and mental health and promoting health-enhancing physical activity among a variety of clinical groups, but there is currently no established protocol for improving both physical and mental health in pediatric cancer rehabilitation.

Objective: This phase I, pilot, feasibility randomized controlled trial aims to investigate the potential effects of a 14-week ER program on physical activity participation and indicators of health among pediatric patients with cancer who undergo bone marrow transplantation.

Mercury(II) halide complex of -[( BuNH)(Se)P(μ-N Bu)P(Se)(NH Bu)].

The mercury(II) halide complex [1,3-di--butyl-2,4-bis-(-butyl-amino)-1,3,2λ,4λ-di-aza-diphosphetidine-2,4-diselone-κ ,']di-iodido-mercury(II),-di-methyl-formamide monosolvate, [HgI(CHNPSe)]·CHNO or ()HgI, , containing -[( BuNH)(Se)P(μ-N Bu)P(Se)(NH Bu)] () was synthesized and structurally characterized. The crystal structure of confirms the chelation of chalcogen donors to HgI with a natural bite angle of 112.95 (2)°.

Individual and prescription level factors associated with overdose in opioid naïve older people.

Background: Opioid naïve older adults may be at risk of overdose after receiving an initial opioid prescription.

Methods: This population-based cohort study from a linked dataset of patients in Oregon, linking all payer claims data to other administrative datasets, aimed to assess the prescription- and patient-level characteristics associated with increased odds of opioid overdose after an initial opioid prescription. Included patients were ≥65 years old and received an index pain-formulation opioid prescription between 2016 and 2019.

The pervasive impact of frailty on ovarian cancer care and the role of prehabilitation: Qualitative perspectives of key stakeholders.

Introduction: We performed a qualitative study to explore key stakeholders' perspectives about the impact of frailty on ovarian cancer care and evaluate a candidate prehabilitation intervention.

Materials And Methods: We conducted semi-structured interviews with patient-caregiver dyads and multi-disciplinary clinicians. Patients were ≥ 50 years of age with a new diagnosis of advanced stage (III/IV) ovarian cancer who received cancer-directed treatment (chemotherapy and/or surgery) during the past year and met criteria as pre-frail or frail using the FRAIL scale.