How Does Thyroid Hormone Profile Differ on and Off Replacement Treatment?

Introduction: There continues to be much discussion around optimisation of thyroid hormone status in hypothyroid individuals. We here looked the way that free T4(FT4) and thyroid-stimulating hormone (TSH) related to each other in a large laboratory sample of people who underwent a thyroid function test (TFT), split between those on levothyroxine replacement (monitoring test) and those who underwent a test to check for thyroid hormone imbalance (diagnostic test; not on levothyroxine).

Methods: TFT test (FT4/TSH) results were extracted from the Salford Royal Hospital Laboratory Information Management System during 2009-2012.

Urban Environmental Threat Moderates the Relationship Between Depression and Insulin Resistance Among Latinxs With Type 2 Diabetes.

As the largest minoritised ethnic group in the United States, Latinxs face a greater risk for type 2 diabetes and depression. The aim of the present study was to explore whether the relationship between depressive symptoms and insulin resistance among Latinxs with type 2 diabetes was moderated by toxic stressors arising from urban environmental threat (i.e.

Comparing expedient and proactive approaches to the planning of protected area networks on Borneo.

Protected areas are an important tool for wildlife conservation; however, research is increasingly revealing both biases and inadequacies in the global protected area network. One common criticism is that protected areas are frequently located in remote, high-elevation regions, which may face fewer threats compared to more accessible locations. To explore the conservation implications of this issue, we consider a thought experiment with seven different counterfactual scenarios for the Sunda clouded leopard's conservation on Borneo.

Tax and Globalisation: Toward a New Social Contract.

Taxation and representation are famously linked in the coercive co-authored project of political governance described through the social contract metaphor. Globalisation transforms this canonical account of the state. Many people can relocate and operate beyond state borders, consuming goods and services publicly offered by other jurisdictions.

Transgender lives at the population level: Evidence from Danish administrative data.

This paper provides the first rigorous account of the diverse characteristics of transgender individuals at the population level, using data from Danish population registers. We observe three transgender subpopulations within the same national setting: all who changed thier legal sex (T-Legal, n = 1,995), all who have been assigned trans-related diagnostic codes (T-ICD, n = 1,594), and those who self-identified as transgender in a representative survey (T-Survey, n = 197, weighted n = 44,958). Results show significant differences in the subpopulations' backgrounds, family, education and labour market characteristics, and healthcare use.

Taking climate-smart governance to the high seas.

Comprehensive spatial planning in international waters is key to achieving ocean sustainability.

Depression and Anxiety Mediate the Relationship between Discrimination and Well-Being in a Sample of Latinx Adults with Type 2 Diabetes: Results from a Dual Mediation Analysis.

Latinxs experience greater risk for type 2 diabetes, discrimination, and poor mental health. The pathways linking these factors, however, are not well understood. This study tested whether depression and anxiety mediated the relationship between discrimination and well-being.

Aspirin Use and Survival Among Patients With Breast Cancer: A Systematic Review and Meta-Analysis.

Background: Previous meta-analyses have indicated that aspirin could affect breast cancer outcomes, particularly when taken post-diagnostically. However, several recent studies appear to show little to no association between aspirin use and breast cancer mortality, all-cause mortality, or recurrence.

Aims: This study aims to conduct an updated systematic review and meta-analysis on the associations of pre-diagnostic and post-diagnostic aspirin use with the aforementioned breast cancer outcomes.

A synthesis and future research directions for tropical mountain ecosystem restoration.

Many tropical mountain ecosystems (TME) are severely disturbed, requiring ecological restoration to recover biodiversity and ecosystem functions. However, the extent of restoration efforts across TMEs is not known due to the lack of syntheses on ecological restoration research. Here, based on a systematic review, we identify geographical and thematic research gaps, compare restoration interventions, and consolidate enabling factors and barriers of restoration success.

The role of volunteering in supporting well-being - What might this mean for social prescribing? A best-fit framework synthesis of qualitative research.

Volunteering for an organisation, charity or group enables people to make connections with others and to be involved in interesting, worthwhile and/or enjoyable pursuits. Engaging in volunteering can form part of a social prescribing action plan developed between a patient and link worker. Greater understanding of the processes through which volunteering can improve people's well-being as part of social prescribing will help to support link workers in their role.

Is microwave ablation an alternative to stereotactic ablative body radiotherapy in patients with inoperable early-stage primary lung cancer?

A best evidence topic was written according to a structured protocol. The question addressed was: in patients with inoperable early-stage primary lung cancer does microwave ablation (MWA) or stereotactic ablative body radiotherapy (SBRT) achieve improved outcomes in terms of local control, recurrence, survival and complications? Altogether, more than 550 papers were found using the reported search, of which 12 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated.

Prevention is Better than Cure, But who Foots the Bill? R (National AIDS Trust) v NHS England.

This case note discusses R (on the Application of National Aids Trust) v The National Health Service Commissioning Board (NHS England), The Local Government Association, The Secretary of State For Health [2016] EWCA Civ 1100. The case is an appeal on an earlier finding by the High Court that the power to commission pre-exposure prophylaxis (PrEP) lies within National Health Service (NHS) England's competence, instead of being within the realm of local authorities' responsibilities. It now forms the sole piece of judicial guidance on NHS England's duties under the National Health Service Act 2006 and is significant for the process by which the Court of Appeal reached its decision.

Choice architecture interventions to improve diet and/or dietary behaviour by healthcare staff in high-income countries: a systematic review.

Objectives: We were commissioned by the behavioural insights team at Public Health England to synthesise the evidence on choice architecture interventions to increase healthy purchasing and/or consumption of food and drink by National Health Service (NHS) staff.

Data Sources: MEDLINE, EMBASE, CINAHL, Cochrane Central register of Controlled Trials, PsycINFO, Applied Social Sciences Index and Abstracts and Web of Science were searched from inception until May 2017 and references were screened independently by two reviewers.

Design: A systematic review that included randomised experimental or intervention studies, interrupted time series and controlled before and after studies.

Choice architecture modifies fruit and vegetable purchasing in a university campus grocery store: time series modelling of a natural experiment.

Background: In developed countries, adolescent and young adult diets have been found to be nutritionally poor. The aim of this study was to examine whether a choice architecture intervention, re-arrangement of produce within a grocery store to increase the accessibility of fruit and vegetables, affected purchasing behaviour on a university campus.

Methods: A database of daily sales data from January 2012 to July 2017 was obtained from a campus grocery store.

'The few cubic centimetres inside your skull': a neurological reading of George Orwell's .

(1949), George Orwell's political satire on state surveillance and mind control, was written between 1946 and 1948, at a time when new thinking in forensic psychiatry coincided with scientific breakthroughs in neurology to bring questions of criminality, psychotherapy and mental health to the forefront of the popular imagination. This paper examines how inverts psychiatric paradigms in order to diagnose what Orwell sees as the madness of totalitarian regimes. It then goes on to place the novel's dystopian vision of total surveillance and mind control in the context of the neurological research and brain scanning techniques of the mid-20th century.

Naked aggression: Personality and portfolio manager performance.

We provide evidence that a personality trait, aggression, has a first-order effect on group financial decision making. In a laboratory experiment on group portfolio choice, highly aggressive subjects (measured by a standard psychology test) were much more likely to recommend risky investment strategies consistent with their own personal information, regardless of the information received by other group members. Outside of this group context, aggression had no effect on subject behavior.

[« Ne nous engageons point dans les querelles » : A project for never-ending war ?].

This article considers the extent to which a quarrel might be a strategic activity for a writer or philosopher making a bid for posterity. Inveterate quarrellers like Voltaire or Rousseau come to mind, but the case to be examined here is the far less straightforward case of Diderot and in particular the stance of 'accidental quarreller' that he fabricates in his Essai sur les règnes de Claude et de Néron et sur les moeurs et les écrits de Sénèque pour servir à l'introduction de la lecture de ce philosophe (1782), the last work he published in his lifetime. The article argues that the Essai constitutes what might be called a « quarrel-text », that is to say a text that stages the quarrel of which it is itself the object and, in so doing, reignites it; it analyses the stance adopted by the philosopher-quarreller as it is revealed in the paradoxical utterance « ne nous engageons point dans les querelles », the performative qualities of which are explored in detail.

Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes.

Background: Specific language impairment (SLI) is a common neurodevelopmental disorder, observed in 5-10 % of children. Family and twin studies suggest a strong genetic component, but relatively few candidate genes have been reported to date. A recent genome-wide association study (GWAS) described the first statistically significant association specifically for a SLI cohort between a missense variant (rs4280164) in the NOP9 gene and language-related phenotypes under a parent-of-origin model.

Charge mobility induced by Brownian fluctuations in π-conjugated polymers in solution.

We study the motion of a doped charge in a π-conjugated polymer chain in solution subject to Brownian fluctuations. Specifically, we take poly(para-phenylene) to be our model system where the Brownian fluctuations cause rotational motion of the phenylene rings. The instantaneous torsional fluctuations cause Anderson localization of the charge wavefunction, with the lower-energy spectrum being composed of local ground states and the higher-energy spectrum being composed of quasi-extended states.