2,525 results match your criteria: "Wonkwang University School of Medicine & Hospital[Affiliation]"

Anatomical etiology of bunny lines based on cadaveric dissection and ultrasonographic evaluation.

Clin Anat

December 2024

Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, South Korea.

Bunny lines are vertical and diagonal wrinkles attributed to contractions of the nasalis muscle. Common management involves botulinum toxin (BoNT) injections into wrinkles immediately below the nasal bridge. Here, we investigated the anatomical structures underneath bunny lines and their relationships with adjacent muscular structures.

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Objective: Popliteal artery entrapment syndrome (PAES) results from an anomalous relationship between the popliteal artery and the myofascial structures of the popliteal fossa. The long-term treatment outcomes are not well known because of the rarity of the disease. This study aimed to establish a nationwide collective dataset, and analyze treatment outcomes.

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Prognostic impact of intravascular imaging in percutaneous coronary intervention according to atherothrombotic risk: a post hoc analysis of a randomized clinical trial.

Rev Esp Cardiol (Engl Ed)

December 2024

Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Electronic address:

Introduction And Objectives: Recent randomized controlled trials support the use of intravascular imaging-guided percutaneous coronary intervention (PCI) to improve patient prognosis. However, the subsequent risk of clinical events in patients with coronary artery disease is not determined solely by lesion characteristics or how these lesions are treated. The current study investigated whether the effects of intravascular imaging in complex PCI vary according to atherothrombotic risks.

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Aim: The definition of metabolic dysfunction-associated steatotic liver disease (MASLD) has recently been proposed. We aim to investigate the diagnostic efficacy of noninvasive fibrosis markers in predicting liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD), metabolic dysfunction-associated fatty liver disease (MAFLD), and MASLD.

Methods: This retrospective study involved 2843 patients diagnosed with steatotic liver disease at six tertiary hospitals in South Korea.

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Background And Objectives: Several real-world studies have been done in patients with nonvalvular atrial fibrillation (NVAF); however, information on its safety profile in patients with renal impairment is limited. XARENAL, a real-world study, aimed to prospectively investigate the safety profile of rivaroxaban in patients with NVAF with renal impairment (creatinine clearance [CrCl], 15-49 mL/min).

Methods: XARENAL is an observational single-arm cohort study in renal impairment NVAF patients.

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Background: Dietary factors are well-known modifiable risk factors for type 2 diabetes (T2D), but many studies overlook the interrelationships between these factors, even though foods are often consumed together and contain a variety of nutrients.

Objectives: In this study, we employed a diet-wide association study approach to investigate the links between various dietary factors and T2D onset, taking into account complex dietary patterns.

Methods: We analyzed 16,666 participants without T2D from three Korean population-based cohorts: the Multi-Rural Communities Cohort ( = 8302), the Atherosclerosis Risk of a Rural Area Korean General Population cohort ( = 4990), and the Kanghwa cohort ( = 3374).

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Introduction: Little is known about age and clinical intervention after implantable loop recorder (ILR) insertion. This study investigated the association between age and clinical intervention after ILR implantation.

Methods And Results: Data were obtained from a multicenter registry of ILR in Korea (2017-2020, n = 795).

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Article Synopsis
  • - This study aimed to determine if tegoprazan is as effective as lansoprazole in healing erosive esophagitis (EE) within four weeks, with a specific focus on rapid mucosal healing and symptom relief by week two.
  • - In a randomized trial of 218 patients, results showed that tegoprazan had significantly higher healing rates compared to lansoprazole at both two weeks (88.4% vs. 82.6%) and four weeks (95.2% vs. 86.2%).
  • - The findings suggest that tegoprazan is superior to lansoprazole for treating EE, but more research is needed to fully understand its advantages, especially for severe cases
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Ginsenosides, active compounds derived from Panax ginseng, exhibit promising potential in enhancing physical performance. This study investigates the impact of UG0712 (UG), a novel ginsenoside compound, on endurance capacity, body weight, organ weights, blood parameters, and specific transcriptomic changes in liver and muscle tissues using a C57BL/6N mouse model. The mice received UGs orally at three doses: UG50 (50 mg/kg), UG100 (100 mg/kg), and UG200 (200 mg/kg) for a specified duration.

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Long-Term Outcome of Rescue Stenting for Acute Intracranial Atherosclerotic Stenosis Related Large Vessel Occlusion in Anterior Circulation.

AJNR Am J Neuroradiol

November 2024

From the Department of Neurology (H.P.), Keimyung University School of Medicine, Daegue, Korea; Department of Radiology (B.M.K., D.J.K.), Interventional Neuroradiology, Department of Radiology, Severance Stroke Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; Department of Radiology (J-W.K.), Yonging Severance Hospital, Yonsei University College of Medicine, Yongin, Korea; Department of Radiology (J.W.K), Yonsei University Wonju Christian Hospital, Wonju, Korea; Department of Neurology (J-H.B), Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Neurosurgery (M.J.K), Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea; Department of Neurosurgery (S.Y), Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea; Department of Neurosurgery (C.K.J), Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea; Department of Neurosurgery (S.K), Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea; Department of Neurology (JN.H), Chung-Ang University, Gwangmeyong Hospital, Gwangmyeong, Korea; Department of Neurosurgery (J-K.K), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; Department of Neurology (I.H.L), Wonkwang University School of Medicine, Iksan, Korea; Department of Neurology (J.H.H., H.S.N., Y.D.K.), Yonsei University College of Medicine, Seoul, Korea.

Background And Purpose: Rescue stent (RS) is an accepted rescue option after failed mechanical thrombectomy (MT) for acute ischemic stroke due to intracranial atherosclerotic stenosis (ICAS)-related large vessel occlusion (LVO). However, the long-term outcomes (≥ 12 months) of RS have not yet been elucidated.

Materials And Methods: We retrospectively analyzed the data of 154 patients with RS for ICAS-related LVO, which were identified from prospectively maintained multicenter database of RS after MT failure, to assess good outcome (mRS 0-2), mortality, stroke recurrence, symptomatic intracranial hemorrhage (SICH) and stent patency.

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The current approaches for detecting most colorectal polyps and early neoplasms lack sufficient sensitivity and specificity, potentially hindering treatment and ultimately reducing survival rates. Here, we performed a metagenomic analysis to identify microbiome markers in stool samples from patients with early-stage colorectal cancer (CRC). We compared the composition of gut microbiota between patients with CRC and healthy individuals, specifically focusing on patients with early-stage CRC, defined as those without core mutations (KRAS, BRAF) for CRC diagnosis, stable microsatellite instability, and distant metastasis.

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Mitochondrial regulation plays a crucial role in cancer immunity in the tumor microenvironment (TME). Infiltrating immune cells, including T cells, natural killer (NK) cells, and macrophages, undergo mitochondrial metabolic reprogramming to survive the harsh conditions of the TME and enhance their antitumor activity. On the other hand, immunosuppressive cells like myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs), mast cells, and tumor-associated macrophages (TAMs) rely on mitochondrial regulation to maintain their function as well.

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Background/aims: We previously reported that patients with moderate-to-severe ulcerative colitis (UC) often experience common mental disorders (CMDs) such as anxiety and depression, necessitating immediate psychological interventions within the first 4 weeks of diagnosis. In this 3-year follow-up study of the MOSAIK cohort in Korea, we examined the effects of CMDs at initial diagnosis on clinical outcomes and health-related quality of life (HRQoL).

Methods: We examined differences in clinical outcomes (evaluated based on clinical response, relapse, hospitalization, and medication use) and HRQoL (assessed using the Inflammatory Bowel Disease Questionnaire [IBDQ] and Short Form 12 [SF-12]) according to Hospital Anxiety and Depression Scale (HADS) scores at diagnosis.

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Article Synopsis
  • * Overlapping DGBI patients tend to have more severe gastrointestinal symptoms and a higher psychosocial burden, influenced by various factors such as gut motility, brain function, immune response, and genetic markers.
  • * Recent research indicates that alterations in the gut microbiome may play a crucial role in the mechanisms of DGBI, which could help refine diagnostic and treatment approaches for better patient outcomes.
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Background: Tobacco use has been the leading cause of disease and death in South Korea. Early detection of tobacco use and evidence-based interventions play pivotal roles in facilitating tobacco cessation.

Methods: In accordance with the earlier iterations of the Lifetime Health Maintenance Program (2009) and recent recommendations from the United States Preventive Services Task Force (USPSTF; 2021), two themes were chosen for investigation: the identification of and intervention for tobacco use.

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Rotenone exposure causes features of Parkinson`s disease pathology linked with muscle atrophy in developing zebrafish embryo.

J Hazard Mater

December 2024

Department of Marine Bio and Medical Sciences, Hanseo University, Seosan-si 31962, Republic of Korea; Department of Aquatic Life Medicine, Hanseo University, Seosan-si 31962, Republic of Korea; Institute for International Fisheries Science, Hanseo University, Seosan-si 31962, Republic of Korea. Electronic address:

Parkinson's disease (PD) is associated with both genetic and environmental factors; however, sporadic forms of PD account for > 90 % of cases, and PD prevalence has doubled in the past 25 years. Depending on the importance of the environmental factors, various neurotoxins are used to induce PD both in vivo and in vitro. Unlike other neurodegenerative diseases, PD can be induced in vivo using specific neurotoxic chemicals.

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Background And Purpose: Nutritional status can influence the outcomes and mortality of various diseases. The association between initial nutritional status and ischemic stroke outcomes, however, remains poorly understood. This study investigated whether the Controlling Nutritional Status (CONUT) score at admission could predict functional recovery, complications, and survival following an ischemic stroke.

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Background/aims: Non-alcoholic fatty liver disease (NAFLD), now the most common chronic liver worldwide, has become a significant public health concern. This study aims to analyze the evolving epidemiology of NAFLD in South Korea.

Methods: We utilized claim data from the Korean National Health Insurance Service from 2010 to 2022 to analyze NAFLD's incidence, prevalence, and progression.

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Objective: Previous research on autism spectrum disorder (ASD) in Koreans has primarily focused on genetic diversity because of its high heritability. However, the emerging recognition of transgenerational epigenetic changes has recently shifted research attention towards epigenetic perspectives.

Methods: This study investigated the DNA methylation patterns of the promoter regions of candidate genes such as , , and in blood samples from ASD probands and their unaffected siblings.

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Article Synopsis
  • The study investigates the prevalence and psychosocial factors of irritable bowel syndrome (IBS) in medical and nursing students in Korea, comparing findings from Rome III and Rome IV diagnostic criteria.
  • Out of 440 students surveyed, IBS was diagnosed in 17.7% using Rome III and 11.6% under Rome IV, indicating a notable decrease in diagnosed cases with the updated criteria.
  • Results showed that those meeting Rome IV criteria experienced more severe symptoms and lower quality of life, highlighting the impact of diagnostic changes on understanding IBS in this population.
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Article Synopsis
  • A study was conducted to explore Korean clinicians' knowledge, attitudes, and practices related to using neuromodulators and psychiatric treatments for functional gastrointestinal disorders (FGIDs).
  • The survey included 451 clinicians from various hospital tiers, revealing that while a high percentage recognized the need for these treatments, many were unfamiliar with prescribing neuromodulators and referred few patients for psychiatric care.
  • Results indicated a significant gap in knowledge and prescribing practices between primary care clinicians and gastroenterologists, highlighting the need for further education on this topic.
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Article Synopsis
  • - The K-REDEFINE study examined Heart Rate Turbulence (HRT) and T-wave alternans (TWA) as potential markers for predicting serious heart conditions in South Korean patients with acute myocardial infarction (MI) or heart failure (HF).
  • - The results showed that abnormal HRT was a strong predictor of adverse cardiac events, including cardiac death and hospitalizations due to heart failure, with a particularly high predictive value when combined with a reduced ejection fraction.
  • - In contrast, abnormal TWA was only associated with the overall risk of cardiac events and did not show as strong a predictive capability as HRT in this study.
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