3,286 results match your criteria: "Witten Herdecke University[Affiliation]"

Objective: Various demographic factors, including sex, socioeconomic status, and immigration status, have been linked to disparities in healthcare outcomes. Despite efforts by healthcare providers to address these inequities, interventions are not always effective. The present investigation provides empirical insights from Germany focusing on patients with systemic connective tissue disorders, highlighting the need for evaluated strategies to mitigate healthcare disparities.

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: The safety and efficacy of electrophysiological (EP) procedures using ultrasound (US) guidance are being increasingly studied. We investigated if a systematic workflow with ultrasound guidance (the US4ABL), comprising four steps (transesophageal echocardiography (TEE) for left atrial thrombus exclusion, US of the groin vessels to guide femoral access, TEE-aided transseptal puncture, and transthoracic echocardiography (TTE) for exclusion of pericardial tamponade after the procedure), reduces the number of complications and fluoroscopy duration and dose. : A total of 212 consecutive patients underwent left-sided ablations using the US4ABL workflow and were compared to a group of 299 patients who underwent the same type of ablations using post-procedural TTE to exclude tamponade (standard group: venous and/or arterial access by palpation and fluoroscopy, and pressure guided transseptal puncture).

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Management of mass casualty incidents: a systematic review and clinical practice guideline update.

Eur J Trauma Emerg Surg

January 2025

Institute for Research in Operative Medicine (IFOM), Faculty of Health, School of Medicine, Witten/Herdecke University, Ostmerheimer Str. 200, 51109, Cologne, Germany.

Purpose: Our aim was to generate evidence- and consensus-based recommendations for the management of mass casualty incidents (MCIs) based on current evidence. This guideline topic is part of the 2022 update of the German guideline on the treatment of patients with severe/multiple injuries.

Methods: MEDLINE and Embase were systematically searched to August 2021.

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Purpose: The aim of this review is to give an overview of the results of prospective and retrospective studies using allogenic reconstruction and postmastectomy radiotherapy (PMRT) in breast cancer and to make recommendations regarding this interdisciplinary approach.

Materials And Methods: A PubMed search was conducted to extract relevant articles from 2000 to 2024. The search was performed using the following terms: (breast cancer) AND (reconstruction OR implant OR expander) AND (radiotherapy OR radiation).

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Background: Nowadays, optimal patient care should be based on data-driven decisions. In the course of digitization, hospitals, in particular, are becoming complex organizations with an enormously high density of digital information. Ensuring information security is, therefore, essential and has become a major challenge.

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Background/objectives: The use of digital media, and especially social media, has been increasing over recent years. Previous research has reported a negative impact of media use on headaches; however, most of these studies are cross-sectional. Therefore, we conducted a longitudinal study to explore the relationship between different types of media usage (watching videos, gaming, and social media) and headache frequency and headache intensity over time.

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: Low back pain (LBP) is a widespread public health issue, with myofascial pain syndrome (MPS) being a common cause, affecting 67-100% of patients. However, there are significant challenges in the diagnostic process due to the subjective and unreliable nature of manual palpation. Focused Extracorporeal Shockwave Therapy (F-ESWT), traditionally used for MPS treatment, offers a reproducible and non-invasive mechanical stimulus, making it a potential diagnostic tool.

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Combined endurance and resistance exercise training in heart failure with preserved ejection fraction: a randomized controlled trial.

Nat Med

January 2025

Department for Preventive Sports Medicine and Sports Cardiology, Technical University of Munich, School of Medicine and Health, TUM University Hospital, Munich, Germany.

Endurance exercise training (ET) is an effective treatment in heart failure with preserved ejection fraction (HFpEF), but the efficacy of resistance training in this patient population has been only scarcely evaluated. In this multicenter, randomized trial, we evaluated the effects of combined endurance and resistance training over 12 months in patients with HFpEF. The primary endpoint was a modified Packer score, including all-cause mortality, hospitalizations classified as potentially related to heart failure or exercise and changes in peak oxygen consumption ( ), diastolic function (E/e'), New York Heart Association (NYHA) class and global self-assessment (GSA).

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Approximation of the infection-age-structured SIR model by the conventional SIR model of infectious disease epidemiology.

Front Epidemiol

December 2024

Biostatistics and Medical Biometry, Medical School OWL, Bielefeld University, Bielefeld, Germany.

During the SARS-CoV-2 pandemic, the effective reproduction number (R-eff) has frequently been used to describe the course of the pandemic. Analytical properties of R-eff are rarely studied. We analytically examine how and under which conditions the conventional susceptible-infected-removed (SIR) model (without infection age) serves as an approximation to the infection-age-structured SIR model.

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Fatal dengue virus infection in an unvaccinated traveler.

Eur J Clin Microbiol Infect Dis

December 2024

Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Dengue is an increasing threat to individuals living in or visiting endemic countries. Effective vaccines have become available, but their use in travelers is typically only recommended to individuals with documented prior infection. We present a fatal case of severe dengue in an unvaccinated traveler without known prior dengue virus infection but longitudinal serologic and molecular evidence for secondary infection.

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Introduction: Intensive interdisciplinary pain treatment (IIPT) is the best therapy available for children and adolescents affected by severe chronic pain. Psychosocial aftercare (PAC) offered for 6 months after IIPT can improve treatment outcomes for up to 12 months.

Objectives: The current study is the first to explore whether PAC is superior to treatment as usual at a long-term follow-up of 18 to 33 months after discharge-including when facing the coronavirus disease 2019 (COVID-19) pandemic.

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Distinguishing Transient From Persistent Brain Structural Changes in Pediatric Patients With Acute Disseminated Encephalomyelitis.

Neurol Neuroimmunol Neuroinflamm

January 2025

From the Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Ultrahigh Field Facility (B.U.F.F.); Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, Germany; Division of Paediatric Neurology, Department of Paediatrics I, Medical University of Innsbruck, Austria; Department of Pediatric Neurology, Olgahospital/Klinikum Stuttgart; Department of Paediatric Neurology, Children's Hospital Datteln, Witten/Herdecke University and Department of Neurology, Charité - Universitätsmedizin Berlin, Germany.

Background And Objectives: Pediatric patients with acute disseminated encephalomyelitis (ADEM) are at risk of impaired brain growth, with long-term neuropsychiatric consequences. We previously reported transient expansions of cerebral ventricle volume (VV) in experimental autoimmune encephalomyelitis, which subsequently normalized. In this study, we investigated changes in VV in ADEM in relation to other brain structures and clinical outcomes.

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Why is it so hard to improve physicians' health? A qualitative interview study with senior physicians on mechanisms inherent in professional identity.

GMS J Med Educ

December 2024

Witten/Herdecke University, Faculty of Health, Chair for the Education of Personal and Interpersonal Competencies in Health Care, Witten, Germany.

Objectives: Current research increasingly describes physicians' health as endangered. Interventions to improve physicians' health show inconsistent results. In order to investigate possible causes for weak long-term effects, we examined senior physicians' perceptions about the relevance of their own health and analyzed whether and how these might affect the difficulty to improve physicians' health.

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The vulva is a periorificial skin area and as such represents a transitional zone with unique functional and physiological characteristics. Knowledge of its anatomy is limited among both the general population and healthcare professionals, and unrealistic expectations of normal proportions are common. Ignorance of anatomical variations can cause unnecessary anxiety.

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Agency as an Inherent Property of Living Organisms.

Biol Theory

August 2024

Institute of Evolutionary Biology and Morphology Centre for Biomedical Education and Research, Faculty of Health, School of Medicine, Witten/Herdecke University, Witten, Germany.

A central characteristic of living organisms is their agency, that is, their intrinsic activity, both in terms of their basic life processes and their behavior in the environment. This aspect is currently a subject of debate and this article provides an overview of some of the relevant publications on this topic. We develop the argument that agency is immanent in living organisms.

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Expectations of doctoral students in the field of medicine and health sciences towards a graduate school: an online cross-sectional survey in Germany.

Front Med (Lausanne)

December 2024

Interprofessional Graduate School for Integrative Medicine and Health, Health Department, Witten/Herdecke University, Witten, Germany.

The doctoral thesis in medicine is a special case, as it is usually started during the course of study and the students have no experience of scientific work. This lack of scientific training is often criticized, and the quality of doctoral theses in medicine is considered low. In order to increase the quality of doctoral theses and the successful completion rate, a structured doctoral programme can provide the appropriate support.

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Histone variant H3.5 in testicular cell differentiation and its interactions with histone chaperones.

Sci Rep

December 2024

Clinical Molecular Genetics and Epigenetics, Faculty of Health, Centre for Biomedical Education & Research (ZBAF), Witten/Herdecke University, Alfred-Herrhausen-Str. 50, 58448, Witten, Germany.

Testicular cell differentiation is a highly regulated process, essential for male reproductive health. The histone variant H3.5 is apparently a critical player in this intricate orchestra of cell types, but its regulation and function remains poorly understood.

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Dimensions and Subcategories of Digital Maturity in General Practice: Qualitative Study.

J Med Internet Res

December 2024

Health Care Informatics, Faculty of Health, School of Medicine, Witten/Herdecke University, Witten, Germany.

Background: The status of the digitalization of companies and institutions is usually measured using maturity models. However, the concept of maturity in general practice is currently unclear, and herewith we examine the question of how maturity can be measured. There is a lack of empirical work on the dimensions and subcategories of digital maturity that provide information on the assessment framework.

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Introduction: Learning motivation is essential to obtain and maintain ultrasound competencies in emergency medicine. One's competencies herein and the need for ongoing training are best evaluated by self-assessment. This may be flawed by overconfidence effects - the belief to be better than others or better than tests reveal.

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Multimodal neurophenomenology of advanced concentration absorption meditation: An intensively sampled case study of Jhana.

Neuroimage

January 2025

Meditation Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Using a combination of fMRI, EEG, and phenomenology ratings, we examined the neurophenomenology of advanced concentrative absorption meditation, namely jhanas (ACAM-J), in a practitioner with over 23,000 h of meditation practice. Our study shows that ACAM-J states induce reliable changes in conscious experience and that these experiences are related to neural activity. Using resting-state fMRI functional connectivity, we found that ACAM-J is associated with decreased within-network modularity, increased global functional connectivity (GFC), and desegregation of the default mode and visual networks.

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Background: Right ventricular-to-pulmonary artery (RV-PA) coupling is an important predictor of long-term survival following transcatheter edge-to-edge repair. However, its impact on survival in patients undergoing indirect mitral annuloplasty is unknown. The study aimed to assess the impact of baseline RV-PA coupling on survival following indirect mitral annuloplasty in heart failure patients.

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Background: Inherited epidermolysis bullosa (EB) comprises a group of genetic disorders characterized by skin fragility and unique oral features. It requires interdisciplinary care from several health professionals, including oral health teams. Modern dentistry encompasses a wide range of therapeutic options performed by specialists from different fields.

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Efficacy and experience of system constellations in virtual reality (VR): study protocol for a randomized controlled feasibility study.

Pilot Feasibility Stud

December 2024

Clinical Psychology and Psychotherapy III, Faculty of Health (Department of Psychology and Psychotherapy), Witten/Herdecke University, Alfred-Herrhausen-Str. 50, Witten, 58455, Germany.

Article Synopsis
  • This study explores the feasibility of using virtual reality (VR) for system constellations (SCs), a therapeutic approach, with a focus on determining the sample size needed for a larger randomized controlled trial (RCT).
  • A total of 128 clients will be divided into two groups: one receiving the VR intervention immediately and the other on a wait-list, allowing researchers to assess both the research methods and the intervention's effectiveness over time.
  • The outcomes measured will include adherence to SC-VR, psychological wellbeing, social functioning, and goal achievement, with follow-ups planned at various intervals to evaluate both short- and mid-term effects of the intervention.
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There are well-established theoretical and empirical foundations for a negative association between trait positive affectivity and anxiety symptoms in anxiety disorders and a positive association between trait negative affectivity and anxiety symptoms, respectively. However, no previous meta-analysis systematically estimated to what extent trait positive and negative affectivity are associated with anxiety symptoms in anxiety disorders. The aim of this study was to conduct a systematic review and meta-analysis to obtain an evidence-based estimate of the associations between trait positive and negative affectivity with anxiety symptoms in anxiety disorders.

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