Sensitivity and Specificity of the Yale Swallow Protocol in Recently Extubated Patients.

Purpose: The purpose of this study was to determine the sensitivity and specificity of the Yale Swallow Protocol (YSP) in detecting aspiration in recently extubated patients.

Method: One hundred fifty-four participants referred for swallowing evaluation underwent the YSP and fiberoptic endoscopic evaluation of swallowing (FEES) in random order within 48 hr of extubation. The YSP included orientation questions, an oral motor exam, and a 3-oz water swallow test.

The Number of Antiseizure Medications Taken and not the Lipid Profile was Associated with Seizure Control in Adult Patients with Epilepsy.

Previous studies show changes in lipid metabolism in epilepsy. The aim of this study was to investigate the association between lipid profile and clinical variables in adult patients with epilepsy (APE). Seventy-two APE participated in this pilot study at an outpatient neurology service.

Mycobacterium paratuberculosis zoonosis is a One Health emergency.

A singular pathogen has been killing animals, contaminating food and causing an array of human diseases. Mycobacterium avium subspecies paratuberculosis (MAP) is the cause of a fatal enteric infectious disease called Johne's (Yo'-nees), a disorder mostly studied in ruminant animals. MAP is globally impacting animal health and imparting significant economic burden to animal agriculture.

Examining Relationships Between GRBAS Ratings and Acoustic, Aerodynamic and Patient-Reported Voice Measures in Adults With Voice Disorders.

Objective: To determine if auditory-perceptual voice ratings performed using the GRBAS scale correlate with acoustic and aerodynamic measures of voice. A secondary aim was to examine the relationship between GRBAS ratings and patient-reported quality of life scales.

Methods: GRBAS ratings, acoustic, aerodynamic and patient-reported quality of life ratings were collected from the University of Wisconsin Madison Voice and Swallow Outcomes Database for 508 adults with voice disorders.

Noise reduction in supercontinuum sources for OCT by single-pulse spectral normalization.

Supercontinuum (SC) sources offer high illumination power from a single mode fiber with large spectral bandwidth including the visible spectrum, a growing application area for Optical Coherence Tomography (OCT). However, SC spectra suffer from pulse-to-pulse variations, increasing noise in the resulting images. By simultaneously collecting a normalization spectrum, OCT image noise can be reduced by more than half (7 dB) for single pulses without any pulse averaging using only simple optical components.

Preoperative FMRI Associated with Decreased Mortality and Morbidity in Brain Tumor Patients.

Background: Functional Magnetic Resonance Imaging (fMRI) is a presurgical planning technique used to localize functional cortex so as to maximize resection of diseased tissue and avoid viable tissue. In this retrospective study, we examined differences in morbidity and mortality of brain tumor patients who received preoperative fMRI in comparison to those who did not.

Methods: Brain tumor patients (=206) were selected from a retrospective review of neurosurgical case logs from 2001-2009 at the University of Wisconsin-Madison.

Predicting primary outcomes of brain tumor patients with advanced neuroimaging MRI measures.

Background: Advanced neuroimaging measures along with clinical variables acquired during standard imaging protocols provide a rich source of information for brain tumor patient treatment and management. Machine learning analysis has had much recent success in neuroimaging applications for normal and patient populations and has potential, specifically for brain tumor patient outcome prediction. The purpose of this work was to construct, using the current patient population distribution, a high accuracy predictor for brain tumor patient outcomes of mortality and morbidity (i.

Assessing Hyolaryngeal Excursion: Comparing Quantitative Methods to Palpation at the Bedside and Visualization During Videofluoroscopy.

Purpose: Hyolaryngeal excursion (HE) is typically assessed via palpation during clinical swallowing exams (CSE) or visually during videofluoroscopy (VFSS). Minimal evidence exists to support the use of these perceptual methods for judging HE. We investigated whether binary judgment of HE differentiates quantitative measures of hyoid movement, using frame-by-frame VFSS analysis to measure anatomically scaled peak hyoid positions.

Corrigendum: Potential role of the glycolytic oscillator in acute hypoxia in tumors (2015 60 9215).

At the time of publication, our group had performed short tandem repeat (STR) testing on the SCC22B cell line and believed that had been correctly identified. As part of a recent comprehensive process to confirm the identity of cell lines in use in our lab, we repeated STR testing on all cell lines. These results were compared to the ExPASy Cellosaurus database (http://web.

5-hydroxymethylation of the EBV genome regulates the latent to lytic switch.

Latent Epstein-Barr virus (EBV) infection and cellular hypermethylation are hallmarks of undifferentiated nasopharyngeal carcinoma (NPC). However, EBV infection of normal oral epithelial cells is confined to differentiated cells and is lytic. Here we demonstrate that the EBV genome can become 5-hydroxymethylated and that this DNA modification affects EBV lytic reactivation.

A simple scheme for generating nearly uniform distribution of antipodally symmetric points on the unit sphere.

A variant of the Thomson problem, which is about placing a set of points uniformly on the surface of a sphere, is that of generating uniformly distributed points on the sphere that are endowed with antipodal symmetry, i.e., if x is an element of the point set then -x is also an element of that point set.

Synthesis of [64Cu]Cu-NOTA-Bn-GE11 for PET imaging of EGFR-rich tumors.

Epidermal growth factor receptors (EGFR) are over-expressed in many different types of cancer, thus, are logical targets for both diagnosis and therapy. Antibodies and antibody fragments targeting the extracellular EGF receptor and small molecules targeting the intracellular tyrosine kinase (TK) part of EGFR have been developed as possible diagnostic EGFR imaging agents. Recently, a 12-amino acid peptide, GE11, was identified using phage display screening to have high affinity for EGFR (Kd=22nM).

Analytically exact spiral scheme for generating uniformly distributed points on the unit sphere.

The problem of constructing a set of uniformly-distributed points on the surface of a sphere, also known as the Thomson problem, has a long and interesting history, which dates back to J.J. Thomson in 1904.

Chromosome 7 and 19 trisomy in cultured human neural progenitor cells.

Background: Stem cell expansion and differentiation is the foundation of emerging cell therapy technologies. The potential applications of human neural progenitor cells (hNPCs) are wide ranging, but a normal cytogenetic profile is important to avoid the risk of tumor formation in clinical trials. FDA approved clinical trials are being planned and conducted for hNPC transplantation into the brain or spinal cord for various neurodegenerative disorders.