74 results match your criteria: "Windsor Clinical Research[Affiliation]"

Background: Olumacostat glasaretil (OG) inhibits acetyl-coenzyme A carboxylase, the enzyme responsible for the first, rate-limiting step in de novo fatty acid synthesis. OG inhibited in vitro human sebocyte lipid production and reduced in vivo sebaceous gland size in hamster ears.

Objectives: Safety and efficacy of OG 7.

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Background: Hidradenitis suppurativa (HS) is a chronic skin disorder with adverse impacts on both physical and psychosocial well-being. There is presently no validated HS-specific quality-of-life (QoL) measure.

Objective: The objective of this study is to develop a QoL instrument for HS (HS-QoL) in accordance with recommended standards.

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Background: The efficacy of current topical acne treatments in mitigating the potential for acne scarring is not known.

Objective: To evaluate the effect of adapalene 0.1%/benzoyl peroxide 2.

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Background: Acne grading is an essential component in establishing treatment options, but little is known on how neck acne should be incorporated into grading scales.

Objective: Our objective was to explore the prevalence of neck acne and determine if its own severity category on an acne global grading scale was warranted.

Methods: Acne severity was assessed in 6 categories: face, chest, back, anterior upper (AUN), anterior lower neck (ALN), and posterior neck (PN).

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Background: Rosacea is a chronic facial disease that may lead to feelings of stigmatization, which can negatively impact psychological and social well-being.

Objective: The aim of this study was to evaluate different aspects of rosacea that could contribute to feelings of stigmatization.

Methods: An online survey of a representative sample of the adult population in the UK, France, Germany and US was conducted to identify patients with rosacea based on presence of three or more clinical features.

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Cost of Medications Recommended by Canadian Acne Clinical Practice Guidelines.

J Cutan Med Surg

November 2016

Independent pharmacist, Wellington Apothecary, Windsor, ON, Canada.

Background: Acne affects a large proportion of the Canadian population and has psychosocial and financial consequences.

Objective: We provide cost information for treatments recommended by the Canadian acne guidelines.

Methods: Highest level recommendations were selected for 3-month usage cost.

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Introduction: Atrophic scarring occurs throughout the course of inflammatory acne and across the spectrum of severity. This study evaluates perceptions of the general population toward individuals with clear skin and acne scars.

Methods: An online survey administered in the USA, UK, Japan, Germany, France and Brazil to respondents 18 years and over presented three facial pictures of clear skin or digitally superimposed acne scars (but no active acne lesions) in a random fashion.

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Fragility of epidermis in newborns, children and adolescents.

J Eur Acad Dermatol Venereol

May 2016

Department of Materials Science and Engineering, Stanford University hospital, Stanford, CA, USA.

Within their first days of life, newborns' skin undergoes various adaptation processes needed to accommodate the transition from the wet uterine environment to the dry atmosphere. The skin of newborns and infants is considered as a physiological fragile skin, a skin with lower resistance to aggressions. Fragile skin is divided into four categories up to its origin: physiological fragile skin (age, location), pathological fragile skin (acute and chronic), circumstantial fragile skin (due to environmental extrinsic factors or intrinsic factors such as stress) and iatrogenic fragile skin.

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Oral Isotretinoin: New Developments Relevant to Clinical Practice.

Dermatol Clin

April 2016

Department of Medicine, Schulich School of Medicine and Dentistry, Western University, Windsor Campus, Medical Education Building, 401 Sunset Ave, Windsor, Ontario N9B3P4, Canada.

Oral isotretinoin is unrivalled in efficacy and remission capability for treatment of acne. In addition to appropriate monitoring and continued vigilance for safety concerns, appropriate dosing to mitigate avoidable dose-dependent adverse effects is the responsibility of prescribers. Low-dose regimens are better tolerated and effective in inducing acne clearance.

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Background: There is an unmet need for general population-based epidemiological data on rosacea based on contemporary diagnostic criteria and validated population survey methodology.

Objective: To evaluate the prevalence of rosacea in the general population of Germany and Russia.

Methods: General population screening was conducted in 9-10 cities per country to ensure adequate geographic representation.

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Background: There are no current instruments to facilitate population screening for rosacea.

Objective: To develop and evaluate a screening instrument for rosacea applicable for population surveys.

Methods: A rosacea-specific screening instrument (Rosascreen), consisting of a subject-completed questionnaire and screening algorithm, was developed based on current diagnostic criteria for rosacea.

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Background: Oral isotretinoin (ISO) is the standard of care for severe inflammatory acne and a threshold dose of 120-150 mg/kg is widely regarded as increasing remission potential.

Objective: Our objective was to evaluate the evidence underlying ISO dosing of 120-150 mg/kg in acne remission.

Methods: A systematic literature search was performed using keywords "acne," "isotretinoin," "efficacy," "dosing," "relapse," and "remission.

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A global perspective on the epidemiology of acne.

Br J Dermatol

July 2015

Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, U.K.

Acne is estimated to affect 9.4% of the global population, making it the eighth most prevalent disease worldwide. Epidemiological studies have demonstrated that acne is most common in postpubescent teens, with boys most frequently affected, particularly with more severe forms of the disease.

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Introduction: Acitretin is a retinoid approved for the treatment of psoriasis that has good efficacy for palmoplantar psoriasis. The safety and efficacy of acitretin in severe chronic hand dermatitis (CHD) is unknown.

Methods: A total of nine patients with severe CHD were enrolled and treated with acitretin 10 mg once daily which could be increased to 30 mg daily if well-tolerated.

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Background: Oral isotretinoin (ISO) is the gold standard for severe nodular acne. However, as some patients are unwilling or unable to take, or are intolerant to, ISO, other options are needed.

Objectives: To compare efficacy and safety of oral ISO vs.

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Improving bioavailability with a novel isotretinoin formulation (isotretinoin-Lidose).

Skin Therapy Lett

July 2014

Department of Medicine, University of Western Ontario, London, ON, Canada; Windsor Clinical Research Inc., Windsor, ON, Canada.

Current practice guidelines recommend administration of oral isotretinoin with high-fat meals, which may pose issues with patient compliance. Isotretinoin-Lidose (Epuris™), approved by Health Canada in November 2012 and scheduled for commercial release June 2013, is based on novel lipid encapsulation technology (Lidose®) to enclose isotretinoin, thereby increasing drug absorption during fasted states. An open label, single dose randomized crossover study demonstrated pharmacokinetic bioequivalence of isotretinoin-Lidose to standard isotretinoin formulations during fed states, with significantly greater absorption during fasting.

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Background: Acne research is hindered by the absence of a universal, consistently applied standard for severity grading. Acne experts recently identified 4 essential clinical components and 2 features for an ideal acne global grading scale (AGGS).

Objective: This study evaluated current AGGSs against consensus criteria previously identified as necessary.

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An observational cross-sectional survey of rosacea: clinical associations and progression between subtypes.

Br J Dermatol

September 2013

Department of Medicine, University of Western Ontario, 1151 Richmond St, London, Ontario, N6A 3K6, Canada; Windsor Clinical Research Inc., 2224 Walker Road, Suite 300B, Windsor, Ontario, N8W5L7, Canada.

Background: Few studies have evaluated differences between rosacea subtypes in epidemiological associations and clinical features. The natural history of rosacea is unknown and progression between subtypes has been implied but not formally evaluated.

Objectives: To assess associations between the four rosacea subtypes [erythematotelangiectatic (ETR), papulopustular (PPR), phymatous (PHY) and ocular], including quantitative and qualitative details on primary and secondary features of rosacea.

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Correlation of photographic images from the Leeds revised acne grading system with a six-category global acne severity scale.

J Eur Acad Dermatol Venereol

March 2013

University of Western Ontario and Windsor Clinical Research Inc., Deptartment of Mathematics and Statistics, University of Windsor, Windsor, Ontario Windsor Program, Schulich School of Medicine and Dentistry, University of Western Ontario, Ontario, Canada Director of Medical Affairs, Stiefel Laboratories, Montreal, Quebec, Canada.

Background: Few global acne grading systems include individualized assessments of chest and back as well as face. The Leeds revised acne grading system is based on photographic images while the Comprehensive Acne Severity Scale (CASS) is based on textual descriptions. There exists an unmet need for a global scale based on both text and photos.

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Few long-term treatment regimens for severe acne vulgaris have been investigated in clinical trials. Data were combined from two consecutive, randomized, double-blind, controlled studies to evaluate the efficacy, safety and subject satisfaction of four nine-month regimens in severe acne vulgaris treatment. Subjects were first randomized to receive doxycycline (DCN) and adapalene 0.

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Acne is a common disorder affecting the majority of adolescents and often extends into adulthood. The central pathophysiological feature of acne is increased androgenic stimulation and/or end-organ sensitivity of pilosebaceous units leading to sebum hypersecretion and infundibular hyperkeratinization. These events lead to Propionibacterium acnes proliferation and subsequent inflammation.

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Background: Topical medications are the most commonly prescribed treatments for acne patients. However, adherence to these treatments and possible associations with clinical severity and quality of life (QoL) impact are unclear.

Purpose: We evaluated the association between sociodemographic factors, clinical severity, and QoL impact and adherence to topical acne treatments.

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Scalp psoriasis has a considerable impact on the quality of life (QOL) of patients, and most patients are dissatisfied with available treatments. Clobetasol propionate shampoo 0.05% has been shown to be effective and safe for moderate to severe scalp psoriasis.

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New developments in hormonal therapy for acne.

Skin Therapy Lett

September 2007

Department of Medicine, University of Western Ontario, London, ON, Canada Windsor Clinical Research Inc, Windsor, ON, Canada.

Oral contraceptives (OCs) are a valuable option for the treatment of women with acne. The use of OCs can be considered across the spectrum of acne disease severity in women. In Canada, three preparations are approved for mild-to-moderate acne, and a fourth is indicated for severe acne.

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