Exploration of Cytokines and Microbiome Among Males and Females with Diarrhea-Predominant Irritable Bowel Syndrome.

Background: Whether pathophysiological factors differ between males and females with irritable bowel syndrome-diarrhea (IBS-D) remains to be tested. To better understand potential sex differences, males with IBS-D were compared to naturally cycling females and to females with IBS-D taking hormonal contraception on plasma levels of cytokines and gut microbiome characteristics.

Methods: Males and females with Rome III IBS-D completed questionnaires and kept a daily symptom diary for 28 days.

Pathways to care for psychosis in rural Uganda: Mixed-methods study of individuals with psychosis, family members, and local leaders.

Background: Low- and middle-income countries (LMICs) bear a disproportionate burden of mental illness, with limited access to biomedical care. This study examined pathways to care for psychosis in rural Uganda, exploring factors influencing treatment choices.

Methods: We conducted a mixed-methods study in Buyende District, Uganda, involving 67 in-depth interviews and 4 focus group discussions (data collection continued until thematic saturation was reached) with individuals with psychotic disorders, family members, and local leaders.

Patterns in coarse root decomposition of woody plants: effects of climate, root quality, mycorrhizal associations and phylogeny.

Coarse roots represent a globally important belowground carbon pool, but the factors controlling coarse root decomposition rates remain poorly understood relative to other plant biomass components. We compiled the most comprehensive dataset of coarse root decomposition data including 148 observations from 60 woody species, and linked coarse root decomposition rates to plant traits, phylogeny and climate to address questions of the dominant controls on coarse root decomposition. We found that decomposition rates increased with mean annual temperature, root nitrogen and phosphorus concentrations.

Resident synovial macrophages in synovial fluid: Implications for immunoregulation.

Resident synovial macrophages (RSMs) are anti-inflammatory, self-renewing macrophages that provide physical immune sequestration of the joint space from the peripheral immune system. Increased permeability of this structure is associated with peripheral immune cells in the synovial fluid (SF). Direct measures of synovial barrier integrity are possible with tissue histology, but after barrier breakdown, if these cells perpetuate or initiate chronic inflammation in SF remains unknown.

Reversing a reported case of transoceanic dispersal: Nudibranch identifications among tsunami debris.

In the aftermath of the 2011 east Japanese earthquake and tsunami, anthropogenic debris from the east coast of Japan floated across the Pacific Ocean to the west coast of North America. One such vessel from Iwate Prefecture arrived on the coast of Oregon, and the fouling community included specimens identified as the nudibranch Hermissenda crassicornis, which was previously thought to range from Japan to Baja California but has since been split into three species: H. crassicornis (northeastern Pacific), H.

Ideological diversity of media consumption predicts COVID-19 vaccination.

This study examines the relationship between respondents' vaccine hesitancy, reported media consumption patterns, ideological leanings, and trust in science. A large-scale survey conducted in the US in 2022 (N = 1,646) assessed self-reported COVID-19 vaccination, trust in science, and reported media consumption. Findings show that, regardless of personal ideology, individuals who consumed less conservative media and had a more ideologically diverse media diet were more likely to be fully vaccinated and boosted.

A cross-sectional exploration of cognitive ability across age via stacked ensembles.

Age-related changes in cognitive and biological processes mean that older adults show markedly lower performance on cognitive assessments than younger adults. Characterizing the precise nature of age-related differences in cognitive performance and whether they vary as a function of key demographic characteristics has been challenging due to small effect sizes, underpowered samples, and blunt analysis methods. In the present study, we address these issues by using a massive cross-sectional data set of approximately 750,000 English-speaking participants who completed at least one battery from the NeuroCognitive Performance Test.

EvoAI enables extreme compression and reconstruction of the protein sequence space.

Designing proteins with improved functions requires a deep understanding of how sequence and function are related, a vast space that is hard to explore. The ability to efficiently compress this space by identifying functionally important features is extremely valuable. Here we establish a method called EvoScan to comprehensively segment and scan the high-fitness sequence space to obtain anchor points that capture its essential features, especially in high dimensions.

A simple action reduces high fat diet intake and obesity in mice.

Diets that are high in fat cause over-eating and weight gain in multiple species of animals, suggesting that high dietary fat is sufficient to cause obesity. However, high-fat diets are typically provided freely to animals in obesity experiments, so it remains unclear if high-fat diets would still cause obesity if they required more effort to obtain. We hypothesized that unrestricted and easy access is necessary for high-fat diet induced over-eating, and the corollary that requiring mice to perform small amounts of work to obtain high-fat diet would reduce high-fat diet intake and associated weight gain.

Race and Superfund site remediation.

Superfund is a federal program established in 1980 to manage the cleanup of hazardous waste sites across the United States. Given the health and economic costs borne by people living near these sites, any demographic disparities within the Superfund program are issues of environmental justice. We investigate whether racial demographics local to a Superfund site are associated with its cleanup status, and if so, how.

Association Between Median Household Income and Perioperative Outcomes of Lumbar Spinal Fusion: An Analysis of the National Inpatient Sample (2009-2020).

Background: Relationships between low socioeconomic status and surgical outcomes are well established for certain procedures. However, scant literature has focused on relationships between median household income and lumbar fusion outcomes.

Methods: Patients who underwent fusion procedures between January 1, 2009 and December 31, 2020 were identified from the National Inpatient Sample database.

Sex differences in opioid response: a role for the gut microbiome?

Opioid drugs have been long known to induce different responses in males compared to females, however, the molecular mechanisms underlying these effects are yet to be fully characterized. Recent studies have established a link between the gut microbiome and behavioral responses to opioids. Chronic opioid use is associated with gut dysbiosis, or microbiome disruptions, which is thought to contribute to altered opioid analgesia and reward processing.

Checking out the unexplained: With age, children become increasingly skeptical of surprising claims.

When presented with surprising claims, older children investigate such claims more often than younger children. The present study tests whether older children (6-7-year-olds) are more skeptical than younger children (4-5-year-olds) about surprising claims that lack supporting evidence because they expect informants to provide evidence for them. To test this hypothesis, we presented 140 4-7-year-old children (47-96 months, 46.

Personality dimensions, depression, and eating behavior in individuals seeking bariatric surgery: a cluster analysis.

Introduction: Psychiatric comorbidity is frequent in bariatric surgery candidates. This study aimed to classify bariatric surgery patients according to patterns of preoperative measures of the severity of the eating disorder (ED), depression, and personality traits.

Methods: In the present cross-sectional study, 115 adult candidates for bariatric surgery (75 females, 65.

Differences in Mental Illness Stigma by Disorder and Gender: Population-Based Vignette Randomized Experiment in Rural Uganda.

Understanding and eliminating mental illness stigma is crucial for improving population mental health. In many settings, this stigma is gendered, from the perspectives of both the stigmatized and the stigmatizers. We aimed to find the differences in the level of stigma across different mental disorders while considering the gender of the study participants as well as the gender of the people depicted in the vignettes.

Incorporating connectivity among Internet search data for enhanced influenza-like illness tracking.

Big data collected from the Internet possess great potential to reveal the ever-changing trends in society. In particular, accurate infectious disease tracking with Internet data has grown in popularity, providing invaluable information for public health decision makers and the general public. However, much of the complex connectivity among the Internet search data is not effectively addressed among existing disease tracking frameworks.

Variable Selection for High-dimensional Nodal Attributes in Social Networks with Degree Heterogeneity.

We consider a class of network models, in which the connection probability depends on ultrahigh-dimensional nodal covariates () and node-specific popularity (). A Bayesian method is proposed to select nodal features in both dense and sparse networks under a mild assumption on popularity parameters. The proposed approach is implemented via Gibbs sampling.

Lipid loss and compositional change during preparation of simple two-component liposomes.

Liposomes are used as model membranes in many scientific fields. Various methods exist to prepare liposomes, but common procedures include thin-film hydration followed by extrusion, freeze-thaw, and/or sonication. These procedures can produce liposomes at specific concentrations and lipid compositions, and researchers often assume that the concentration and composition of their liposomes are similar or identical to what would be expected if no lipid loss occurred.

Politicizing science funding undermines public trust in science, academic freedom, and the unbiased generation of knowledge.

This commentary documents how federal funding agencies are changing the criteria by which they distribute taxpayer money intended for scientific research. Increasingly, STEMM (Science, Technology, Engineering, Mathematics, and Medicine) funding agencies are requiring applicants for funding to include a plan to advance DEI ("Diversity, Equity, and Inclusion") in their proposals and to dedicate a part of the research budget to its implementation. These mandates undermine the academic freedom of researchers and the unbiased generation of knowledge needed for a well-functioning democracy.

Steep Decline in the Rare Flat Abalone, Haliotis walallensis, Following Fishing Exploitation and a Marine Heat Wave: The Next Neoextinction?

Ocean warming is impacting marine systems directly and indirectly via intensifying multiple stressors such as hypoxia, acidification, and kelp forest collapse potentially exacerbating neoextinctions. Abalones are extremely vulnerable to both ocean warming and fishing stressors making them marine "canaries in the coal mine". The rare flat abalone, Haliotis walallensis, has been subject to a targeted commercial fishery and then exposed to an extreme marine heat wave.

Overturning Children's Misconceptions about Ruler Measurement: The Power of Disconfirming Evidence.

Children have persistent difficulty with foundational measurement concepts, which may be linked to the instruction they receive. Here, we focus on testing various ways to support their understanding that rulers comprise spatial interval units. We examined whether evidence-based learning tools-disconfirming evidence and/or structural alignment-enhance their understanding of ruler units.